Healthcare Unfiltered
187 episodes - English - Latest episode: 19 days ago - ★★★★★ - 125 ratingsHealthcare Unfiltered is an honest, raw, timely podcast tackling any and all topics in healthcare that affect stakeholders. Dr. Chadi Nabhan uses his dynamic conversational skills to challenge his guests to address controversial and important topics. He also brings on world renowned experts to discuss clinical advances in medicine.
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Episodes
Press Releases, Pre-Prints, Abstracts, and Papers: Reviewing the Peer-Review Process
June 29, 2021 11:18 - 49 minutes - 91.4 MBVincent Rajkumar (@VincentRK), MD, Mayo Clinic, and Editor-in-Chief of Blood Cancer Journal, rejoins the show to answer some critically important questions related to medical publications and information reliability in the pandemic and post-pandemic world. As a consumer of medical news, which sources of information should you take seriously? Should you ignore press releases and pre-prints in favor of abstracts or papers? Should peer-reviewed literature be your only source of reliable informat...
What to Consider When Considering the Keto Diet
June 22, 2021 11:00 - 56 minutes - 103 MBChadi dives into the world of nutrition and dieting with Kevin Bass, MD, PhD student in Texas; Ethan Weiss, MD, cardiologist; and Aaron Goodman, MD, hematologist and current subscriber to the Ketogenic diet. The groups begins with a history of the “Keto” diet and how it has transformed into a popular diet for weight loss, what goes into the traditional Keto diet and how to do it effectively, controversy surrounding the diet and whether it is associated with adverse health effects, reasons to ...
An Update on the COVID Situation in India
June 15, 2021 10:58 - 50 minutes - 93.3 MBTo provide an update on the COVID spike and response in India over the past 6 weeks since Chadi’s previous episode, Aju Mathew (@ajumathew_), MD, oncologist practicing in southern India, joins the show. Dr. Mathew begins by describing the tradeoffs of moving home to practice in India while leaving his academic career behind in the US, offers critical remarks on India’s government use of resources to combat COVID up to and during the “tsunami,” shares how vaccine hesitancy around the world ble...
Medical Bullying and Physician Suicide: Laura Silinskyte’s Story
June 08, 2021 10:53 - 1 hour - 126 MBIn early May, a Lithuanian doctor named Laura Silinskyte committed suicide after facing constant bullying from her superiors at her regional hospital. To shed light on the issue of medical bullying and physician suicide, Chadi is joined by two friends of Dr. Silinskyte—Monika Arzanauskaite, a radiologist, and Gil Morgan, a medical oncologist—as well as a personal friend Laurie Gordon, an adult and child psychiatrist with experience treating healthcare workers. Monika and Gil share who Laura w...
The Oncologist as a Caretaker: A Husband and Wife Story
June 01, 2021 11:15 - 1 hour - 120 MBFor this special episode, Chadi invites John Marshall (@marshalj23), MD, Chief of the Division of Hematology/Oncology, Medstar Georgetown University Hospital, and his wife Liza Marshall, a lawyer by training who was diagnosed with triple-negative breast cancer 15 years ago. John and Liza co-wrote a book, titled Off Our Chests, about their shared experience of overcoming her diagnosis – told from the perspective of the caregiver as well as the patient. The couple open up about their individual...
Should CNS Prophylaxis be Given to DLBCL Patients?
May 25, 2021 11:14 - 1 hour - 84.7 MBChadi welcomes “Papa Heme,” or Aaron Goodman (@AaronGoodman33), MD, hematologist at University of California San Diego, and Matt Wilson (@mattwilson2287), MD, Beatson West of Scotland Cancer Centre (UK), to debate the importance and utility of CNS prophylaxis for patients with DLBCL. The trio explain the origins of the debate, who the high-risk patients are in the first place, whether better systemic control is a better strategy for these patients, how to weigh the benefits against the toxici...
Optimizing Clinical Trial Design with Bishal Gyawali
May 18, 2021 11:24 - 1 hour - 97.4 MBBishal Gyawali (@oncology_bg), MD, PhD, Queen’s University Cancer Research Institute (Canada), joins the show to discuss the measurement of clinical benefit of new therapies and optimizing clinical trial design. Dr. Gyawali recaps a presentation he gave at last year’s ESMO Annual Meeting on clinical trial characteristics leading to artificial improvement of ESMO-MCBS scores for cancer drugs, goes on to list in detail the ten trial design characteristics that inflate the scores (including the ...
COVID Vaccine Passports: Necessary or Nefarious?
May 11, 2021 14:53 - 58 minutes - 107 MBRecurring guests Saurabh Jha (@RogueRad), MD, radiologist in Philadelphia, and Vinay Prasad (@VPrasadMDMPH), MD, MPH, hematologist/oncologist in San Francisco, seek to settle the debate surrounding COVID vaccine passports. Both scholars defend their recently published viewpoints – Dr. Jha arguing for passport mandates and Dr. Prasad arguing against them. Will requiring proof of vaccination be driven by the business sector, local or federal governments, or anywhere in between? Will vaccines he...
COVID-19 and the Tragedy in India: The Real Story
May 04, 2021 10:33 - 1 hour - 125 MBTo truly understand the gravity of the somber COVID situation in India, Chadi hosts Parameswaran Hari, MD, MRCP, chief of oncology, Medical College of Wisconsin, and Nikita Mehra, MD, associate professor of medical oncology, Cancer Institute Adyar (India). Dr. Hari begins by providing a ground-floor perspective of the COVID situation in India from his visit there just a few weeks ago, including how the country fared in 2020 compared to the current day and how hospital systems are managing in ...
Near Equivalence and Designing Cost-Effective Cancer Therapies
April 27, 2021 11:26 - 57 minutes - 105 MBChadi hosts three medical oncologists to break down “near equivalence” for alternative standard-of-care cancer therapies – a new paradigm published in detail in the Journal of Clinical Oncology. Ian Tannock, MD, PhD, Princess Margaret Cancer Center (Canada); Mark Ratain, MD, University of Chicago; and Daniel Goldstein, MD, Rabin Medical Center (Israel), describe what is meant by “near equivalence” and the practice of generating evidence to support global alternative cost-effective treatments....
Lung Cancer Screening: Myths and Controversies
April 20, 2021 11:29 - 54 minutes - 101 MBChadi hosts two thoracic oncologists to dish and debate on the nuances of lung cancer screening: Charu Agarwal, MD, MPH, University of Pennsylvania, and Lecia Sequist, MD, MPH, Massachusetts General Hospital and Harvard Medical School. The trio start by making the case for screening the healthy, low-risk population as well as people with a smoking history, and then jump into a round-up of clinical trials that have shown a positive impact from screening. The highly-questioned JAMA publication ...
COVID-19 and Mental Health: No Easy Answers
April 13, 2021 11:28 - 45 minutes - 83.4 MBGeorge Dawson (@dawso007), MD, addiction and neuropsychiatrist in Minnesota, joins Chadi to discuss mental illness and COVID – of having the virus itself, as well as the result of isolation and lack of social interaction. Dr. Dawson shares how individuals with drug or alcohol addictions have struggled to stay sober while being stuck at home without in-person meetings and human interaction, whether there is reason to believe the COVID lockdowns and social restrictions have worse health ramific...
History of Medicine: Bone Marrow Transplantation and Cellular Therapy
April 06, 2021 11:27 - 1 hour - 116 MBKrishna Komanduri (@drkomanduri), MD, chief of the division of transplantation and cellular therapy, University of Miami Sylvester Comprehensive Cancer Center, joins the show to provide a fascinating account of the history of allogeneic and autologous transplantation, the discovery of the difference between B cells and T cell, and up through modern cellular therapy with a forecast for the future decades. This is a crash course in cellular and CAR-T therapy that you won’t want to miss.
Mental Illness and Firearm Law with Amy Barnhorst and Rocco Pallin
March 30, 2021 11:05 - 1 hour - 114 MBChadi invites Amy Barhorst (@amybarnhorst), MD, and Rocco Pallin, colleagues at UC Davis Health, to tackle the stigma and underdiagnosing of mental health in America and how mental illness intersects with gun violence in this country. The experts delve into whether community and person-to-person violence should be largely attributed to mental illness as well as why policy changes are the clearest way to eliminate mass shootings. Then, the conversation pivots to a true story of how their Revie...
Artificial Intelligence with Amazon Practice Manager Aziz Nazha
March 23, 2021 11:37 - 49 minutes - 90.2 MBAziz Nazha (@AzizNazhaMD), MD, former hem/onc at Cleveland Clinic, self-taught computer science expert, and now practice manager in the Data and Machine Learning Team at Amazon Web Services, joins the show to discuss artificial intelligence (AI) and machine learning from an entirely unique perspective. He details the pitfalls of unstructured healthcare data, privacy and ownership issues related to healthcare data and whether hospitals should be allowed to sell their patient data, why AI lagge...
Simplifying the COVID-19 Vaccines With Priya Sampathkumar
March 16, 2021 11:30 - 51 minutes - 94.5 MBChadi is joined by Priya Sampathkumar (@PSampathkumarMD), MD, infectious disease specialist and hospital epidemiologist, Mayo Clinic, to detail the COVID vaccine effort over the past 12 months and how the currently approved ones came to be safe and effective in such a short period of time. She then compares each vaccine in relation to their clinical trials and study populations, side effects (including some rare ones), and efficacy. Chadi and Dr. Sampathkumar converse on what it will take for...
Cardiology and Boxing Promotion: A Sit-Down With Andrew Foy
March 09, 2021 12:24 - 58 minutes - 107 MBAndrew Foy (@AndrewFoy82), MD, cardiologist at Penn State University, joins the show to discuss publishing bias for medical research along with the psychological dilemma as a result of the pandemic of sacrificing personal liberties for the safety of others. The conversation pivots to Dr. Foy’s experience with boxing at a young age and how he eventually channeled that love into promoting the sport. How can promoting a boxing match be similar to planning a wedding? How can a full-time cardiolog...
ASCO-GU Virtual Meeting Round-Up With Toni Choueiri
March 02, 2021 12:33 - 1 hour - 142 MBToni Choueiri (@DrChoueiri), MD, Dana-Farber Cancer Institute, joins the show to guest host a discussion with Rana McKay (@DrRanaMcKay), MD, UC San Diego, and Alicia Morgans (@CaPsurvivorship), MD, MPH, Northwestern University, on the practice-changing abstracts presented at the 2020 ASCO-GU virtual meeting. The trio weigh the importance and real-world implications of the ACIS study for mCRPC, EV-301 for advanced or metastatic urothelial carcinoma as well as CheckMate 274 for muscle-invasive ...
Beyond ADAURA: What's Right and What's Wrong With FDA Regulations?
February 23, 2021 12:23 - 54 minutes - 98.9 MBChadi welcomes back Jack West (@JackWestMD), MD, associate clinical professor and medical oncologist, City of Hope Comprehensive Cancer Center, and Nathan Pennell (@n8pennell), MD, PhD, thoracic medical oncologist, director of the thoracic oncology program and director of clinical research, Cleveland Clinic, to the show. The task was to break down the ADAURA trial again, but to go beyond ADUARA and explore the use of various endpoints in lung cancer and how trials should be optimally designed...
Resurfacing Old Drugs: Lessons From "Chasing My Cure"
February 16, 2021 12:27 - 1 hour - 112 MBDavid Fajgenbaum (@DavidFajgenbaum), MD, MBA, MSc, assistant professor in the department of medicine at the University of Pennsylvania, as well as the associate director of patient impact for the Penn Orphan Disease Center, joins the show to talk about his experience writing and receiving feedback on the national bestseller “Chasing My Cure” as a survivor of Castleman disease – a commentary on how he turned hope into action and discovered an old drug that had never been researched in Castlema...
Debates and Controversies in Multiple Myeloma
February 09, 2021 12:30 - 1 hour - 133 MBVincent Rajkumar, (@VincentRK), MD, hematologist at the Mayo Clinic (Rochester, MN), joins the show to guest host a debate between Sagar Lonial (@SagarLonialMD), MD, FACP, chief medical officer of Winship Cancer Institute of Emory University, and Rafael Fonseca, (@Rfonsi1), MD, interim director of Mayo Clinic Cancer Center. These multiple myeloma “gurus” dive into imaging, smoldering disease, endpoints, maintenance, minimal residual disease, and so much more.
ASCO-GI Virtual Meeting Round-Up With Tanios Bekaii-Saab
February 02, 2021 12:28 - 58 minutes - 106 MBTanios S. Bekaii-Saab (@GIcancerDoc), MD, professor of medicine and director of the GI oncology program at the Mayo Clinic (Phoenix, AZ), joins the show to highlight the research with significant clinical application presented at the virtual ASCO-GI meeting, including KEYNOTE-177 and ATOMIC in colorectal cancer, atezolizumab plus bevacizumab for first-line HCC, a survival update in the POLO trial and utility of radiation for pancreatic cancer, PD-1 inhibitors for first-line and adjuvant treat...
What to Expect From Medicare Part D in 2021
January 26, 2021 12:32 - 46 minutes - 86.1 MBStacie Dusetzina (@DusetzinaS), PhD, associate professor of health policy, Vanderbilt University Medical Center, joins the show to expound on the changes that have been made to Medicare Part D since its inception during the Bush administration, how Part D is failing the older population in need of expensive drugs, and the counterintuitive state of generic drug affordability for Part D recipients. Chadi and Stacie then discuss how changes in the presidential administration will impact Part D c...
Vaccine Distribution and Mandate Ethics With Alison Bateman-House
January 19, 2021 12:34 - 57 minutes - 105 MBChadi welcomes back Alison Bateman-House, (@ABatemanHouse), MPH, PhD, medical ethicist at New York University’s School of Medicine, to break down COVID-19 vaccine distribution and mandates. Why has vaccine distribution not been an efficient and effective process? Are the right people being prioritized in the vaccine pecking order? Should vaccine doses be immediately available to anybody and everybody to make strides toward herd immunity? Should a “first dose only” vaccine approach be adopted ...
Cardiology, Comedy, and COVID-19 with Rohin Francis
January 12, 2021 12:33 - 1 hour - 114 MBRohin Francis (@MedCrisis), cardiologist in the UK, brings his expertise and unique sense of humor to the show to share how he’s combined comedy with medical education through his Twitter and YouTube presence, how he sifts through the vast expanse of COVID-19 research for data that is useful and legitimate, the apparent inability to have an open scientific debate on Twitter without being chastised or judged for your viewpoints, and so much more. Check out Dr. Francis’ videos at https://www....
Drug Approvals and Real-World Use: The Case of Selinexor in Multiple Myeloma
January 05, 2021 12:28 - 1 hour - 121 MBAaron Goodman (@AaronGoodman33), MD, hematologist/oncologist, University of California San Diego, and Jatin Shah (@JatinShahMD), MD, executive vice president and chief medical officer, Karyopharm Therapeutics, join the show for a deep consideration of oncology drug approvals in the context of RCTs, RWE, surrogate endpoints, and outcomes. The larger discussion is framed around Karyopharm’s STORM study of selinexor in refractory multiple myeloma and whether the FDA had enough convincing data to...
Recapping 2020: A Year of COVID-19, Tradeoffs, and Censorship
December 29, 2020 12:31 - 1 hour - 159 MBIn an enthralling yet informative roundtable discussion, Chadi hosts Saurabh Jha (@RogueRad), MD, radiologist and frequent guest of the show; Vinay Prasad (@VPrasadMDMPH), MD, MPH, hematologist/oncologist and former guest of the show; and Sally "Loyal Listener"(@barttels2), patient advocate, to breakdown 2020 like only they can. These titans of the MedTwitter world dissect and opine on lessons to be learned from COVID-19 (warts and all), the diminishing space for public discourse and healthy ...
Advances in Multiple Myeloma From the ASH Annual Meeting
December 22, 2020 12:25 - 46 minutes - 86 MBRafael Fonseca (@Rfonsi1), MD, interim director of Mayo Clinic Cancer Center, shares with Chadi his picks for the most clinically applicable multiple myeloma studies coming out of the ASH virtual meeting, including notes on transplantation, frontline therapy, the “belle of the ball” bispecific antibodies, CAR-T therapies, and MRD monitoring.
Words Matter: The Patient Perspective of Language Used on Social Media
December 15, 2020 12:24 - 41 minutes - 76.2 MBLaura Lee (@lauraelee), JD, a lawyer by training and journalist in North Carolina, brings her unique perspective to the show to discuss how language used on social media to describe the outcomes of clinical trials and the tolerance of therapies in a patient population can be damaging to patients on an individual level. She expresses some of her larger concerns in the way medical information is displayed and discussed online, including the tone that is used, how quality of life measures fall s...
Real-World Evidence and Value-Based Care in the Academic World
December 01, 2020 12:25 - 57 minutes - 105 MBYousuf Zafar (@yzafar), MD, GI oncologist and associate professor of medicine, Duke University, highlights perspectives that are missing from the “general rubric” of value-based care in oncology, how real-world evidence (RWE) can help augment takeaways from clinical trial data, issues of capturing the patient voice in real-world data and electronic health records, and how the FDA is utilizing RWE for expanding drug indications. Dr. Zafar shares where he sees the intersection between RWE and v...
Direct-To-Consumer Advertising in Healthcare: Legality and Ethics
November 24, 2020 12:24 - 58 minutes - 107 MBAlison Bateman-House (@ABatemanHouse), MPH, PhD, medical ethicist at New York University’s School of Medicine, explains the distinction between direct-to-consumer (DTC) advertising of doctors and drugs to that of consumer goods, as well as regulatory and ethical concerns of DTC advertising on the part of hospitals and drugs. Chadi and Dr. Bateman-House grapple with questions of whether healthcare is simply a consumer good or if it is something more and whether DTC advertising should be banned...
Advocacy in a Time of Uncertainty: Jill Feldman’s Ongoing Battle With Lung Cancer
November 17, 2020 12:36 - 1 hour - 118 MBJill Feldman (@jillfeldman4), lung cancer survivor and advocate, shares her familial history of lung cancer that drove her to advocacy work long before her own diagnosis of EGFR-positive disease, as well as her treatment courses with erlotinib and subsequent SBRT for many years before osimertinib. Jill then describes her “journey” in advocacy, beginning with self-advocacy and the LUNGevity Foundation, independent research advocacy and representing lung cancer patients, and co-founding the EGF...
Measurable Residual Disease: Hype or Hope?
November 10, 2020 12:35 - 54 minutes - 99.5 MBAmeet Kini (@AmeetRKini), MD, PhD, hematopathologist, and Patrick Hagan, MD, hematologist/oncologist, both at Loyola University Medical Center, deliberate on the clinical importance of MRD and how clinicians should utilize it, optimal techniques for detecting MRD in various diseases, the gap between academia and the community when it comes to MRD knowledge, the potential of MRD as a surrogate marker, and how to reconcile discordant MRD results from different vendors.
COIs in Medicine: A Broken System
October 27, 2020 11:49 - 55 minutes - 102 MBVincent Rajkumar (@VincentRK), MD, hematologist at the Mayo Clinic (Rochester, MN), shares the distinction between conflicts of interest that guide individual physicians and those that guide entire practices, what types of conflicts should be collected as “material” and which should be disregarded (eg, “transfer of value” payments), issues with disclosure expectations in modern medical research, and an idea to create standards for more appropriate and warranted disclosures. Watch a previous ...
Expert Roundtable: Genitourinary Updates and Top Data
October 20, 2020 11:47 - 1 hour - 122 MBChadi facilitates a discussion between three GU oncologists on the latest research and treatment updates in the field. Rana McKay (@DrRanaMcKay), MD, UC San Diego, Petros Grivas (@PGrivasMDPhD), MD, PhD, Fred Hutchinson Cancer Research Center, and Toni Choueiri (@DrChoueiri), MD, Dana-Farber Cancer Institute, debate the practice-changing potential of chosen papers and abstracts presented at ASCO and ESMO, including updated data on the final OS in the PROFOUND trial, context and implications o...
CRISPR: Monumental Technology and Noble Prize Winner
October 13, 2020 11:44 - 49 minutes - 91 MBJohn Doench (@JohnDoench), PhD, Associate Director of the Genetic Perturbation Platform, Broad Institute of MIT and Harvard, joins Chadi for a fascinating discussion on the history of CRISPR as a scientific breakthrough, the ease of merging CRISPR technology into human cells, challenges remaining for CRISPR to become a widely used clinical tool and ultimately helping patients, and much more.
Cardiology, COVID-19, and College Sports: What Went Wrong
October 06, 2020 11:46 - 1 hour - 127 MBIn the inaugural episode of Healthcare Unfiltered, host Chadi Nabhan invites cardiologists Venk Murthy (@venkmurthy), MD, University of Michigan, and Anish Koka (@anish_koka), MD, private practice in Philadelphia, to contextualize the effects of COVID-19 on the heart, as explained in a flawed JAMA Cardiology publication that was close to having such trickle down effects as cancelling college sports across the US. The trio explains how the study should not be used to treat patients with preexi...