Authentic Biochemistry
765 episodes - English - Latest episode: 1 day ago - ★★★★★ - 10 ratingsBecome a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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Episodes
SERPIN mediates transcriptional control over pro-tumorigenic pathways including a phosphatidyl inositol 1,3 kinase delta mediated mechanism.
June 30, 2019 01:20 - 28 minutes - 26.2 MBDr. Guerra focuses on emerging signaling and immunoepigenetic variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra admits Serpin mediated cancer ablation is multivalent and pharmaceutically treacherous
June 29, 2019 05:00 - 29 minutes - 27.5 MBDr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeutic anisotropy. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j...
Introduction to Proteases and Protease Inhibitors as Prolegomena to Specific HCC pathophysiology
June 26, 2019 00:42 - 29 minutes - 26.6 MBDr.Guerra of Authentic Biochemistry provides a primer on polypeptide proteases and their mode of action as well as their control via processing and inhibition in clinical medicine --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
HCC Episode VII. Dr Guerra tackles the pathogenecity of the serine proteinase inhibitor paradigm . 08 JUne 2019
June 08, 2019 23:30 - 28 minutes - 25.8 MBSerine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease potentiation leading to subcellular protein aggregation, enhanced inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient conditions in HCC. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/s...
Hepatocellular Carcinoma Pathobiochemistry Chapter/Lecture V from Dr. Daniel J. Guerra. Authentic Biochemistry.28 May 2019.
May 28, 2019 18:21 - 28 minutes - 26.3 MBIn this segment I provide more discussion of the published evidence linking glycolytic pathway enzymes to HCC progression. The expression of certain interfering RNA's that differentially regulate gene expression and promoter habilitation can lead to cyclin dependent kinase mediated chromatin remodeling enhancing cell -specific expression of enzyme isoforms that promote rather than defeat disease progression. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-gue...
Dr Guerra Characterizes How Glycolytic Enzymes Proxy Oncogenically in Prodromal Hepatocellular Carcinoma. 26 May 2019
May 26, 2019 15:23 - 28 minutes - 25.7 MBDr. Guerra of Authentic Biochemistry continues with the 4th in a series of HCC lectures from the primary research literature by explaining the interacting roles of pyruvate kinase M2 and phosphofructokinase 2 promote aerobic glycolysis-enhancing cancer progression. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra introduces the pseudo-paradoxical irony of Pyruvate kinase M2 expression toward the biochemical Aetiology of HCC
May 23, 2019 02:03 - 28 minutes - 26.1 MBAuthentic Biochemistry's host, Dr Dan Guerra, continues his in depth cellular and molecular discussion of hepatocellular carcinoma (HCC) by introducing the non-universal yet a priori role for the glycolytic enzyme pyruvate kinase isoform M2 in paradigmatic tumor associated aerobic glycolysis. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Authentic Biochemistry Podcast. Dr. Dan Guerra presents Heptaocellular Carcinoma Part II: Metabolic and Signal Transduction Cascades
May 17, 2019 19:18 - 28 minutes - 26.3 MBDr Guerra takes a deeper dive into the hormonal and subcellular dysfunctional arrays linking obesity to Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra Starts his podcast lecture sequence on Obesity and Hepatocellular Carcinoma. Series session#1
May 15, 2019 18:35 - 28 minutes - 26.1 MBThis is Part One of what will be a 3-5 part sequence of podcast lectures giving Authentic Biochemical discussion concerning the links between obesity , sedentary lifestyle, alcohol consumption and inflammatory diseases of the liver that may lead to the high mortality cancer, Hepatocellular Carcinoma. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
HDAC 4 is a positive player in ALS muscle since it is not a functional histone deacetylase: The complexity of motor neuron disease reveals not-so-subtle differences in protein function
April 16, 2019 19:06 - 27 minutes - 24.9 MBBecause HDAC4 closely resembles the structural component of the superfamily of histone deacetylases, in might be assumed it functions to catalyze the removal of LYS bound acetate. But since HDAC4 does not contain the catalytically necessary TYR-OH but rather an HIS-imidizole it has no deacetylase enzymatic activity. However HDAC4 does interact with other proteins and the net result is protective of skeletal muscle atrophy and motor neuron degeneration in a murine mutant human SOD1 model of ...
Dr Guerra continues : Glutamate induced ferroptosis involves lipid peroxidation and ceramide production leading to an inflammatory response in neurodegeneration
March 25, 2019 23:19 - 29 minutes - 27.5 MBDr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Daniel Guerra introduces a novel PCD pathway- ferroptosis- that is linked to excitotoxicity and lipid peroxidation leading to neurodegeneration. Part I
March 25, 2019 20:44 - 26 minutes - 24.1 MBThis is the first part of a diaeventontological framing of lipid peroxidative mechanisms for CNS neurodegeneration. Dr Guerra describes recent published research (JLR 2018 .59:312pp.) and develops some of the key elements of the ferroptosis programmed cell death mechanism leading to oligodendrocyte and neuronal degeneration that will participate in a grander understanding of injury-induced and idiotypic age-associated disease in the CNS. 25 March 2019. --- Support this podcast: https:/...
Authentic Biochemistry #3. Dr Guerra verifies the evidence to a future biochemical prolegomena for Alzhiemer's Disease
March 10, 2019 01:23 - 27 minutes - 25.6 MBIn this podcast, Dr Daniel Guerra of Authentic Biochemistry and VerEvMed endeavours to examine the bioenergetic and pro-inflammatory prodromal patho-biochemistry of age-onset Alzheimer's Disease using his diaeventontological toolkit. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Diaeventontology of Biological Systems
February 27, 2019 21:42 - 45 minutes - 41.6 MBDr. Daniel J. Guerra introduces his paradigmatic shift for understanding biochemical phenomena as prolegomena to understanding Alzheimer's Disease. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Introduction to Authentic Biochemistry Podcast
February 23, 2019 23:31 - 15 minutes - 14.1 MBDr Daniel Guerra of Authentic Biochemistry in his initial podcast introducing the show and starting off with initial content on current Alzheimer's Disease research --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support