Dr Guerra admits Serpin mediated cancer ablation is multivalent and pharmaceutically treacherous

Authentic Biochemistry

English - June 29, 2019 05:00 - 29 minutes - 27.5 MB - ★★★★★ - 10 ratings
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Previous Episode: Introduction to Proteases and Protease Inhibitors as Prolegomena to Specific HCC pathophysiology

Next Episode: SERPIN mediates transcriptional control over pro-tumorigenic pathways including a phosphatidyl inositol 1,3 kinase delta mediated mechanism.

Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeutic anisotropy.

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