Authentic Biochemistry
765 episodes - English - Latest episode: 1 day ago - ★★★★★ - 10 ratingsBecome a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
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Episodes
Further Inquiries into The Immune System and The Aging Central Nervous System: The PDH/LDH/PDHK1 Axis. Dr. Dan Guerra 13 December 2020.
December 13, 2020 21:34 - 29 minutes - 27.1 MBDr. Guerra reminds and extends his decade-long hypothesis that The Immune Response could function to generate the networked synaptic connections in the brain during initiation, development, learning, and aging. The question considered is how do immune cells and immuno-regulatory proteins such as cytokines and chemokines and immunoglobulins recognize certain neurons and not others? The mechanism for maintaining and increasing synaptic strength vs. obsolescence and programmable cell death co...
What T -cell Acute Lymphoblastic Leukaemia and Senescing microglial CNS disease have in common relate to Notch and Glucocorticoid signaling. DJGPhD 07 December 2020
December 08, 2020 00:44 - 29 minutes - 27.3 MBAging and chronic stress can obtain activation of CNS-resident microglia and astrocytes, that produce type 1 interferons (T1 IFNs) which signal through the heterodimeric IFN-α/β receptor (IFNAR) where receptor binding of T1 IFNs activates the JAK/STAT thus inducing IFN-stimulated genes (ISGs) which mediate both pro- and anti-inflammatory functions depending upon the cellular micro-environment. Now consider how aging is linked to elevated & activated leukocyte counts and it becomes clear...
Dr. Guerra interrogates Notch signalling in T lymphocte early development as prolegomena to immunodystrophy obtained with aging. 05 Decemeber 2020
December 06, 2020 03:07 - 29 minutes - 27 MBIn this first pre-Christmas present Authentic Biochemistry Podcast lecture, Dr Guerra examines the multifactorial expansion of NOTCH signalling through early thymocyte development as regulated by paracrine and endocrine hormonal systems in cooperation with the exemplary plenum of IL7 cytokine mediated signalling through the phosphatidylinositol and AKT kinase cascades. References J Cell Physiol. 2003 Mar;194(3):237-55 Development 2019 146: dev172148 Int J Mol Sci. 2020 Nov; 21(21): 797...
From Bioenergetics to Cardiac Function and Thymocyte differentiation in the Aging Population. Dr. Daniel J. Guerra 02 December 2020.
December 03, 2020 03:24 - 29 minutes - 27.1 MBIn today's lecture, Dr Guerra explains how subclinical hypothyroidism obtains increased serum thyrotropin (thyroid stimulating hormone, TSH) with flat levels of of free thyroxin (T4) and biologically active free triiodothyronine (T3) in the elderly;β1 adrenergic receptors, sodium/potassium ATPase, voltage-gated potassium channels, malic enzyme and atrial and brain natriuretic factor all respond favourably to thyroxin and hese proteins form the primary architecture of the cardiomyocyte and de...
Dr. Guerra herds the Hippo Pathway into T lymphocyte mediated autoimmune disease and cancer in the aging human Authentic Biochemistry 16 November 2020
November 16, 2020 22:14 - 29 minutes - 26.8 MBOn this 16th of November Authentic Biochemistry Podcast episode acknowledging my sister Carol's birthday, I explain the MST- kinase mediated transcription factor HIPPO pathway and its potentially gravid linkage to aging associated lymphocyte-informed autoimmune disease, cancer and neurodegeneration. Published by Dr.. Daniel J. Guerra. 2020 References Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Pharmacological Research Volume 143, May 2019, Pages 151-165 Trends...
T cell receptor excision circles (TRECs) are generated in the thymus and are potential indicators of acquired immune disorders in neuropsychiatry and senescence.
November 15, 2020 01:20 - 29 minutes - 26.9 MBDuring thymic T lymphocyte recombinatorial self avoidance, the processing obtained in T cell receptor excision generates small circular DNA byproducts that may be used as a biomarkers for thymic output and for the relative ability of T lymphocytes to fight infection, tumors, and obesity -linked cardiovascular disease and metabolic disorders that may become important pathologies in the aging human population. Transcription factors like Nfil3 are important components of this networked age...
Dr. Guerra explains the ID2 HLH pseudo transcriptional corridor in leukemia and aging. 11 November 2020
November 12, 2020 02:05 - 29 minutes - 27 MB1.Id proteins are helix-loop-helix (HLH) proteins lacking the basic amino acid domain necessary to bind DNA.and therefore ID functions in a dominant negative manner by sequestering ubiquitously expressed or cell- restricted basic HLH transcription factors: this results in effective blockade of transcription since ID causes a failure of dimerized basic HLH proteins to bind DNA. 2. Id proteins regulate transcription factors that are involved in developmental processes such as myogenesis,...
Multiple Transcription Factor functional integration from immune cell lineages coordinate gene expression that maintains responses to intestinal infection during aging
November 10, 2020 21:17 - 29 minutes - 27.5 MBSince epithelial clock gene and lymphocyte transcription factor Nfil3 expression is elevated in recombination deficient mice the potential for increased bacterial populations lining the gut may induce an expansion of class 3 innate-like T lymphocytes (ILC3) in the small intestine. thus allowing for circadian clock activity maintenance and effective immune clearance of potential pathogens. This observation may provide a potential pathobiochemical link between obesity and the increasing pa...
Transcription Factor NFil3 tracks the circadian clock to microbiome linked immune cascade in the gut. Dr. Daniel J. Guerra 09 Nov. 2020
November 10, 2020 02:34 - 29 minutes - 27 MBNFIL3 is a critical transcription factor immunologically linking the microbiome to the circadian clock and lipid metabolism where the Innate Lymphoid Cell subtype 3 and dendritic cells may stipulate the intestinal microfloral associated epithelial temporal chronicity. Subscribe to my Podcast and donate! Published by Dr Daniel J Guerra, Authentic Biochemistry 09 November 2020 Reference: Science. 2017 Sep 1; 357(6354): 912–916. --- Support this podcast: https://podcasters.spotify.c...
Dr Guerra illustrates that NFIL3 represses genes by recruiting Sirtuin 2 and G9a histone methyltransferase eo ipso regulating diverse biological processes,
November 02, 2020 02:17 - 29 minutes - 27.2 MBNuclear factor interleukin 3 (NFIL3, also known as E4-binding protein 4, E4BP4) is a repressor of numerous genes. NFIL3 contains a basic leucine zipper domain, comprising amino acids 73–146, among 462 residues; the N-terminal part of this domain directly binds to DNA, while the C-terminal region is responsible for homo- or heterodimerization of the protein. Amino acids 299–363 comprise a transcriptional repression domain where the N-terminal part of this domain directly binds to DNA, while t...
The Circadian clock and the Acquired Immune Response coordinate at the event of transcription factor mediated aging phenotype. Dr Daniel J. Guerra
October 29, 2020 23:30 - 29 minutes - 26.7 MBDr. Guerra hybridizes multiple strands of published biochemical research to obtain an event ontology for potentiating factors leading to the aging human pathophysio9logical phenotype. In this lecture I include the following detail: 1. Nuclear factor interleukin 3 (NFIL3, also known as E4-binding protein 4, E4BP4) is a repressor of numerous genes. where an N-terminal domain directly binds to its response element, while the C-terminal region is responsible for homo- or heterodimerization t...
Animals have adapted behavioral responses corresponding with light and temperature events to respond to and anticipate basic bioenergetics due of heterotrophy. Authentic Biochemistry . 28/10/2020
October 29, 2020 00:39 - 29 minutes - 27 MBSince space and time are never the same twice and indeed are relatively uncertain, not even the day/night chronicity is a true cycle. It is a pattern or a familiar sequence of events and nothing more. No two moments are identical and so our internal circadian clock tracks these patterns but the means by which this detection operates at the cellular and molecular level, as well as the event itself involving the revolving celestial bodies in constant flux so in time, the pattern becomes less u...
While Melatonin binding to the MT1 and MT2 receptors may benefit aging via suppression of oncogenic gene expression and enhancement of the SCN sleep wake cycle, receptor loss occurs with senescence.
October 25, 2020 02:40 - 29 minutes - 27.2 MBThe pharmaceutical Remelteon may be a better MT1 MT2 agonist mimetic for decreasing melatonin synthesis in the aging pineal because it fails to bind MT3 receptor which is an active quinone reductase 2 synthesizing superoxide system. Published 24 October 2020 by Authentic Biochemistry Podcast; Dr Daniel J. Guerra --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
L-TRP is precursor to MEL and NAD ;Mel regulates Sirtuins which Perform DSB repair; NAD metabolism after SIRT activity yields PAR for SSB repair. DJGPhD 21 Oct 2020.
October 22, 2020 00:02 - 28 minutes - 26.5 MBThe artificial enhancement of brain melatonin levels were hoped to suppress the progress of Alzheimer's Disease in humans and for correcting the circadian and sleep-wake disturbances associated with advanced aging.. However, given the complex association of melatonin on NAD+ tonicity and this relationship playing a role in DNA Damage Repair Responses (both SSB and DSB) . melatonin or a surrogate mimetic receptor agonist may have undesirable effects on neurodegeneration and oncogenesis in ...
The Association of NAD+, Melatonin, &Sirtuins via DNA Damage Repair and Epigentic Chromatin Remodeling with Immunosenescence is evident
October 21, 2020 21:32 - 30 minutes - 27.5 MBThis episode lays the foundation for a common precursor-the essential amino acid L-tryptophan, of both melatonin and NAD+ and the PARP mediated DNA repair pathways linked to tumorigenesis on one hand and in DNA Damage repair-linked cessation of apoptosis on the other, in the aging human Central Nervous System. Cells. 2019 Sep; 8(9): 1047. Int J Alzheimers Dis. 2011: 741974. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
DDR and the roles of Sirtuins and the NAD metabolic paradigm in aging. Published by Authentic Biochemistry Dr. Daniel J. Guerra 19 Oct 2020
October 20, 2020 00:30 - 29 minutes - 26.9 MBThe pineal endocrine hormone melatonin proximally decreasesIL-1β-induced MMP production by inhibiting Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes; since autoinflammatory Osteoarthritis (OA) is a degenerative joint (cartilage degradation) disease linked to human aging and Interleukin-1β contributes to OA pathogenesis by enhancing oxidative stress and inflammation the role(s) of sirtuin and NAD+ metabolism is associated with aging morbidity while also being described in Double...
Dr Guerra presents :"Deacetylase Agency in NAD+ and ADP Ribose Metabolism as the Equipoise for Cell Fate In Aging and Disease" 14 Oct.2020
October 15, 2020 02:14 - 29 minutes - 26.7 MBDr. Guerra offers a deep investigation into the roles of sirtuins in homeostasis , aging and disease as linked to NAD+ metabolism via ecto enzymatic CD38 and intracellular forms of this NAD+ metabolizing enzyme that is associated with T lymphocyte bioenergetics, activation and regulation as embedded within the inflammatory response, disease and aging. Published in Authentic Biochemistry Podcast series on Aging and the immune system. 14 October 2020 Papers mentioned in today's lecture : Hog...
Dr Daniel J. Guerra of Authentic Biochemistry lectures on Senescence in Human Aging: The Sirtuin Intrusion
October 12, 2020 22:41 - 29 minutes - 26.9 MBSirtuins are protein deacetylases with multiple isoforms active in the nucleus, cytosol and mitochondria all serving unique functions and requiring NAD+. These sirtuins function to condense chromatin and yet protein abundance has less to do with potency than does the availability of NAD+ which can be synthesized from multiple routes. Furthermore, SIRT1 has been associated with antagonizing age-related decreases in the amplitudes of the SCN output obtaining age-linked differentiating phase...
Dr. Guerra obtains a dialectical analysis of the pineal hormone melatonin in deacetylase-mediated Respiratory disease and aging
October 08, 2020 23:35 - 29 minutes - 26.9 MBIt is proposed that the endocrine hormone melatonin may regulate after its synthesis and secretion from the pineal gland, the deacetylase acivity of Sirtuin1 to diminish the SASP repertoire of aging and may be linked to common morbidity of pathophysiology linked to COPD and generic Respiratory Distress Syndrome (RDS)presentation. Papers of Record in this episode Int J Mol Sci. 2019 Mar; 20(5): 1223. Int. J. Mol. Sci. 2014, 15, 16848-16884 International Immunopharmacology Volume 62, Sep...
Dr. Daniel Guerra presents Immuno Diaeventontological Framing of the Aging Human IV: SASP to cGAS via Melatonin
October 08, 2020 00:46 - 29 minutes - 27 MBDr. Guerra temporally organizes the lecture series toward the dialectical event by mindfully schematizing the SASP , the triad of DNA Damage Repair (DDR)responses, transcriptionally activated pro-inflammatory cytokine mediated inflammation, and the pineal-endocrine hormone melatonin circadian clock manifestations in the biochemistry and physiology of the aging human. Please SUBSCRIBE! and when you can PLEASE DONATE to your favorite authentic biochemist so he can continue to provide with...
Dr. Guerra finds that the tumor-promoting and suppressing biochemical phenotypes of senescence are phenomenologically contrarion and thus physiologically compatible
October 04, 2020 19:04 - 29 minutes - 26.6 MBLipids, proteins carbohydrates and nucleotides-may function within an inflammatory and secretory modality. Thus, the SASP-Senescence-Associated Secretory Phenotype might deliver apoptosis, necroptosis, autophagy, oncogenesis or an extended senescence sequalae. An Authentic Biochemistry audio lecture podcast by Dr. Daniel J. Guerra. 04 October 2020. Please SUBSCRIBE , check out my video lectures ( https://www.youtube.com/channel/UCcEoA2N9WSlNvDk1BtuznfQ?view_as=subscriber) and donate! ...
Is cancer. or survival-achieving chemotherapy to treat early-onset tumorigenesis, linked to late in life senescence and human aging? The CD8+ T lymphocyte link.
September 27, 2020 01:22 - 22 minutes - 20.3 MBA take-home message from this research may be that the immunosenescent phenotype in the elderly, while associated with an increased rate of infections and a diminished effect of vaccines, and increased cancer susceptibility may be promoted by cancer and /or chemotherapy to cure the cancer. Both cancer and chemotherapy contribute to immune compromise and potential for gene mutations and epigenetic phenomena. Please subscribe to Authentic Biochemistry podcast and donate to its continued longe...
Dr Guerra suggests targeting senescence as a means to alter the rate of aging is contrarion to healthy outcome because of derepression of tumorigenesis.
September 22, 2020 00:05 - 30 minutes - 27.5 MBThe human body is tempered by cellular fate paradigms that include senescence vs. proliferation during aging. A corruption in the senescnce associated secretory phenotype may be a proximal tareget to reduce aging morbidity but does it not open the door to oncogenesis and the potential for autoimmune disease? Comput Struct Biotechnol J. 2019; 17: 1151–1161 Nat Med. 2017 Jun; 23(6): 775–781 Support your biochemistry podcast! Be "Authentic" and send donations now! Dr Guerra thanks you ! -...
Senescence and Aging Relative to T lymphocytes may be linked to chemotherapy of testicular cancer and underlying cell cycle-CD transcriptional mutations.
September 20, 2020 21:40 - 29 minutes - 26.9 MBDr Guerra continues his associative pathobiochemical dialectic concerning T lymphocytte differentaition and senescence The Th and Tc populations following uptake and processing of an antigen by an APC such as a dendritic cell is presented either to the CD8 population in the context of MHC-I or to the CD4 subpopulation in the context of MHC-II generates a cascading set of cellular lymphoproliferative and differentiative steps initiated under the inductive influence of cytokines that ultimat...
Thymic involution-associated naive cd4+/cd8+ Tcell differentiation as observed in care-giver neuropsychological conditioning toward non-chronological immunosenescence.
September 18, 2020 23:42 - 28 minutes - 26.5 MBDr Guerra swings hard at Treg and naive CD4+/CD8+ lymphocytes in immunosenescence and the potential for infection with aging while accumulating T memory cell lineages confined to antigen./pathogen exposure including vaccine-associated immunizations. Newe paper disussed today: .Brain Behav Immun 2018 Oct; 73: 546–549.doi: 10.1016/j.bbi.2018.06.019. Epub 2018 Jun 22. PLeasse donate to Authentic Biochemistry! I need your financial support in these trying times. --- Support this podcast: h...
The teleology of Thymus mediated T regulatory cell clonal elimination and expansion via membrane associated receptor ligand interactions with innate and lymphocyte linneages. Dr Daniel J. GUERRA
September 17, 2020 02:14 - 28 minutes - 26.4 MB1. Age -associated Immunosenescence is sometimes treated as synonymous with immune insufficiency, resulting in enhanced random infections and reduced vaccine immunity, and tumor surveillance 2. Self-reactive immune responses are elevated in the elderly, which is a result of inflammaging, a chronic, low-grade, systemic pro-inflammatory phenotype in the absence of acute infection 3. Immunosenescence and inflammaging are pathophysiological, and can be the immune poise for hyperinflammation a...
Dr Guerra presents: The Agency of the Immune System Treg Lymphocytes in Senescence and Human Aging. Authentic Biochemistry Podcast.14 September 2020
September 14, 2020 19:01 - 28 minutes - 26.5 MBCellular senescence is a physiological process with genetic determinants and external modififiersincluding stress, nutrition and cell fate reprogramming including autophagy and apoptosis. Human aging is a lifelong teleological process that includes the specifics of cellular senescence plus an underdefined terminus that tracks chronological longevity and occurs in all systems including musculature, solid organs, the PNS and the CNS Aging is at the organismal level and is inevitable with inc...
Glucocorticoid Associated Naive Treg Differentiation and the Role of T Memory and Treg Sub-populations in Aging and End Stage Renal Disease
September 09, 2020 00:36 - 28 minutes - 26 MBDr Guerra discusses the Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) and its role in stabilizing T Regulatory cell populations relative to T memory cells and T effector Cells in healthy and End-Stage Renal Disease patients of differing chronological age. This plank is laid down to form the final structural foundations that allow us to examine dialectically, the role(s) of the Immune system on aging and the chronic and auto-immune diseases of the elderly. Pub...
Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.
September 01, 2020 22:31 - 25 minutes - 23.8 MBDr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 September 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020
August 24, 2020 23:53 - 27 minutes - 24.9 MBDr. Daniel Guerra recombines the discussions of pharmacotherapeutic inhibition of prenylation in T cell activation and the failure of the NF-Kappa B pathway in estrogen receptor associated breast cancer and the lymphoproliferative lymphomas and leukemias with aging and neurodegeneration. PUblished 24 August 2020. Please join our Patreon and contribute to Authentic Biochemistry today! --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra
August 19, 2020 00:42 - 28 minutes - 26.4 MBDr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of prenyl and acyl lipogenesis, Published 18 August 2020 by Dr Daniel J. Guerra. Review of: Front. Pharmacol., 17 March 2020. https://doi.org/10.3389/fphar.2020.00265 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.
August 07, 2020 00:22 - 28 minutes - 26.4 MBIn this segment I discuss the phenomenon of DNA and genomic instability and the DNA repair systems implemented as mechanisms to drive cellular longevity . 06 August 2020 . --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020
August 05, 2020 23:51 - 29 minutes - 26.7 MBProgrammed Cell Death is a classical cell fate that occurs during embryonic development, tissue repair and both leucocyte and lymphocyte turnover. Various subforms of apoptosis ( classical, necroptosis and ferroptosis) are also involved during infection, genotoxicity, oncogenesis and aging. Published By Dr Guerra 05 August 2020. Subscribe to the podcast! Contribute on Patreon! --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype
August 04, 2020 20:06 - 29 minutes - 26.7 MBDr Guerra discusses the cancer marker gene mKI67 and its turnover linked to predisposition to euchromatin formation and the progression toward a senescent phenotype. Published 04 August 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020
August 02, 2020 19:26 - 27 minutes - 25.5 MBThe mevalonic acid biosynthetic pathway maintains canonical cell activation triggers that link intermediary metabolism to T lymphocyte differentiation. 02 August 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020
August 01, 2020 21:11 - 29 minutes - 26.8 MBThe master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating AMPK may reduce glioblastoma progression and this observation helps to advance a theory for healthy longevity that requires a reduction in anabolism. By Dr Daniel J. Guerra. Published 01 August 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020
July 30, 2020 21:52 - 29 minutes - 27 MBIn this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.
July 28, 2020 00:31 - 29 minutes - 27.2 MBDr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.
July 26, 2020 21:32 - 29 minutes - 26.9 MBDr Guerra explains chain initiation, propagation and termination during lipid oxidation and the REDOX reactions of the electron transport chain as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020
July 25, 2020 04:06 - 29 minutes - 26.9 MBDr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is related to the auto-oxidation of nucleic acids, protein and significantly, membrane unsaturated molecular species of lipids. 24 July 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.
July 24, 2020 18:36 - 29 minutes - 26.8 MBDr Guerra explains how mutations in the glycolytic enzyme, pyruvate kinase, may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.
July 21, 2020 21:49 - 29 minutes - 26.6 MBDr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.
July 19, 2020 22:30 - 29 minutes - 26.9 MBToday I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support! https://podbay.fm/podcast/1454408625 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .
July 12, 2020 02:44 - 28 minutes - 26.3 MBThe synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020
July 10, 2020 19:58 - 28 minutes - 26.1 MBAirway passage disease has been well characterized in cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020
July 09, 2020 23:05 - 27 minutes - 25.4 MBDr Guerra presents his existential view on the purposive avoidance in science to admit the significance of belief in the knowledge paradigm. 09 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020
July 08, 2020 19:24 - 28 minutes - 26.4 MBDr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.
July 03, 2020 18:41 - 28 minutes - 25.8 MBDr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally, a mechanistic step-wise summary of the serine protease catalytic triad is presented. Published 03 July 2020. --- Support this podcast: https://podcasters.spotify.com/pod/sho...
The Role of Alpha anti-trypsin in the IL-1 pro-inflammatory cascade. 30 June 2020
June 30, 2020 22:08 - 28 minutes - 25.7 MBFar from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and tumor microenvironments. Dr Dan Guerra 30 June 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
SERPINs and the Acute Phase Response in the Pathophysiological State. Dr Dan Guerra, 29 June 2020
June 29, 2020 22:08 - 28 minutes - 25.9 MBDr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support