Authentic Biochemistry
765 episodes - English - Latest episode: 1 day ago - ★★★★★ - 10 ratingsBecome a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
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Episodes
Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21
December 07, 2021 01:36 - 29 minutes - 27.4 MBCell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant expression of Cell Cycle dependent kinase inhibitors and the relative production of pro-inflammatory cytokines under the synchrony of DNA Damage Repair (DDR), telomerase expression decline, and the protective role of the Senescence Associated Secretory Phenotype (SASP). Dr. Daniel J. Guerra. 06 Dec 2021 Authentic Biochemistry Productions References: Onco...
Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry
November 25, 2021 01:47 - 29 minutes - 27.1 MBAge Ageing, Volume 48, Issue 6, November 2019, Pages 776–782 Biomedicines. 2020 Aug 6;8(8):277 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21
November 21, 2021 01:59 - 29 minutes - 27 MBDr. Guerra authentically arrives at the inveighing cancer paradigm contribution to the sickness unto death. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21
November 18, 2021 03:22 - 29 minutes - 26.8 MBNutrients. 2020 Mar; 12(3): 622. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43.The Immune System and Its Dysregulation with Aging Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD.
November 14, 2021 02:34 - 29 minutes - 27.4 MB1.Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43. The Immune System and Its Dysregulation with Aging. Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers. 2. Aging (Albany NY). 2019 Apr 30; 11(8): 2343–2351. 3. Immun Ageing. 2020; 17: 2 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Fine detail of Treg cell control over inflammation suppression via FoxP3 transcriptional modulation. Aging and Obesity will limit this control leading to hyperinflammation. DJGPhD. 08Nov2021
November 09, 2021 00:30 - 29 minutes - 27.5 MBReferences Front. Immunol., 29 June 2012 J Immunol 2016;197:3762-3770 Front. Immunol., 03 February 2020 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
T cell receptor signaling kinase dynamics after APC activation. Co-activating CD28 becomes deficient via immunosenescence thus corrupting T cell efficiency in the elderly. 26.10.2021 DJGPhD.
October 27, 2021 01:03 - 29 minutes - 27 MBThe Src-family kinase Lck regulates T-cell development, activation, proliferation, and immune synapse dynamics. These are the initiation phases of TCR signaling. Upon antigen presentation via the APC- TCR immune synapse, Lck phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAMs) of the TCR-associated CD3 membrane protein domains. Phosphorylated ITAMs function as a molecular platform for tandem SH2 domains located on the tyrosine kinase Zap-7...
Indeed oxysterol LDL , circulating hepatic-derived convertase, T lymphocyte differentiation and macrophage to foam cell degeneration obtain the aging cardiovascular/pulmonary pathophysiological state.
October 22, 2021 23:07 - 29 minutes - 27.4 MBDr Guerra carries out the synthesis of multiple pathobiochemical events into an architechtonic of the aging human co-morbidity resulting in a sickness unto death. Authentic Biochemistry Production 22 October 2021 References Cardiovasc Diabetol. 2020; 19: 33. Cytometry A. 2006 Mar;69(3):189-91 Nat Rev Dis Primers. 2019 Mar 7;5(1):16 J Lipid Res. 2007 Jan;48(1):19-29. doi: 10.1194 Mech Ageing Dev. 2001 Sep 15;122(13):1413-30 --- Support this podcast: https://podcasters.spotify.com/...
How Oxysterol LDL associates with macrophage and T lymphocyte infiltration during aging to generate the hyperinflammatory atherosclerotic plaque. DJGPhD. 19.10.21. Authentic Biochemistry.
October 20, 2021 01:13 - 29 minutes - 27.1 MBThat there are senescence-associated decreases in the JAK-STAT signaling transduction cascade has been observed in human lymphocyte lineages. This phenomena, as associated with a decreased JAK- tyrosine phosphorylation of STAT5, is linked to plasma membrane cholesterol content. Therefore, plasma membrane cholesterol content is involved in T cells modulation and proliferation. Acid sphingomyelinase- mediated ceramide lipid raft mobilization and aggregation of membrane receptors plays a cru...
Aging results in corruption of T lymphocyte differentiation associated with chromatin instability and epithelial to mesenchymal transitions leading to the pre-cancerous state. DJGPhD 16.10.21
October 16, 2021 19:23 - 29 minutes - 27.4 MBChromatin instability leads to alterations in gene expression that re-directs cellular senescence by corruption of chemokine and cytokine signalling resulting in epithelial to mesenchymal transitions and the potential for metastatic cancer in the elderly . As lymphocyte lineage's age these underlying pathobiochemical events are potentiated by hypo and hyper immune responses thus generating a downward reductio to misdirected hyperinflammatory states and the potential for autoimmune disease s...
Lymphocyte maturation and the special Innate like Lymphocyte Subclass including Natural Killer and other ILC lineages. DJGPhD.14.10.21. Authentic Biochemistry
October 14, 2021 21:48 - 29 minutes - 27.5 MBFront Cell Dev Biol. 2019; 7: 226 Advances in Immunology. 2011 v.109.Pp125 Cell Reports 10, 2043–2054, March 31, 2015 Experimental & Molecular Medicine volume 51, pages1–15 (2019) --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Immunosenescence and Inflammaging via thymic Involution and comorbid pathophysiology of obesity and aging present a chronic inflammatory phenotype prone to morbidity. DJGPhD. Oct.04,2021. Authentic BC
October 05, 2021 01:16 - 30 minutes - 27.5 MBDr. Guerra details the aging immune phenotype at the transcriptional and metabolic level. References Immun Ageing. 2020; 17: 2. Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Nat Immunol. 2011 Nov 6; 12(12): 10 Cell 146, 772–784, September 2, 2011 Nat Immunol. 2014 Aug; 15(8): 767–776. Cell Reports Volume 17, Issue 11, 13 December 2016, Pages 2827-2836 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Natural cytotoxicity receptors (NCR's) within group 3 innate lymphoid cells (ILC3): an association of transcription factors in IBD's and aging. DJGPhD. 03.10.21 Authentic Biochemistry.
October 04, 2021 01:09 - 29 minutes - 27.4 MBILC3 can contribute to the progression and aggravation of IBD's while both IL-22 and IL-17, along with IFN-γ, are overexpressed by the dysregulation of NCR− ILC3 or NCR+ ILC3 function NCR (natural cytotoxicity receptors), are type 1 transmembrane proteins of the immunoglobulin superfamily. Upon stimulation, NCR's mediate NK killing and release of IFNγ. They bind viral ligands such as hemagglutinins, neuraminidases, bacterial ligands, and cellular ligands related with auto immune diseases,...
Omega three fatty acids and PE N-methyl transferase are associated with methylation and acetylation patterning in NK cells via AMPK and stress.DJGPhD. 29 September 2021.
September 29, 2021 21:45 - 29 minutes - 27.3 MBOmega-Three VLCPUFA's as asymmetrically distributed in membrane glycerolphospholipids mediate vesiculation and permeability of endothelia to circulating lymphocytes and leukocytes thus coupling folic acid, Vitamin B12 and epigenetic modification of chromatin to ultimately link bioenergetics with cytotoxicity and inflammation. This regulated system involves the neuroimmunoepigenome and the senescent environment of aging human vasculature, skeletal and cardiac muscle, and the CNS toward pathob...
Natural Killer Cell switching via demethylation of Histone 3 LYS may correlate with the human aging phenotypic hyper-inflammatory state. DJGPhD. 28.9.21
September 28, 2021 23:42 - 29 minutes - 27.5 MBPro-inflammatory gene transcription is tanked when demethylation is inhibited but cytotoxicity of virally infected or cancer cells by NK’s (where demethylation is inhibited) remains intact. References J. Biol. Chem. 2018;293:2422-2437 J. of Biol. Chem. 2016. 291, 23756-23768 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Genome and the Immunoepigenome interact across a three-way trigonal planar field with the Environment to Obtain the Aging Phenomena. DJGPhD.27.9.21
September 28, 2021 00:08 - 30 minutes - 27.5 MBDr. Guerra discusses some of the complexity of both the epigenetic mechanisms and cellular responses associated with immunomodulatory failure in the aging human. References Anal Cell Pathol (Amst). 2018; 2018: 787.1814. Daniel J. Guerra. 2018. DOI: 10.5772/intechopen.82176 https://www.intechopen.com/chapters/64596 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Natural Killer cells and the epigenomics of gene expression: implications for the aging -senescent human. DJGPhD. 26 .9.21. Authentic Biochemistry
September 26, 2021 22:52 - 29 minutes - 27.1 MBDr. Guerra continues a dialectical accounting of the biochemical and cellular events leading to the terminal outcome of aging. Topic today is the reintroduction of Natural Killer Cells and the epigenetic mechanisms that orchestrate unique gene expression. References Anal Cell Pathol (Amst). 2018; 2018: 787.1814. The Journal of Biological Chemistry2018. 293: 2422-2437 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
REDOX Biochemistry Primer . DJGPhD Authentic Biochemistry . 24.9.21
September 24, 2021 21:03 - 28 minutes - 26.2 MBOxidases, dehydrogenases and oxygenases in the electron transport chain et al. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Video Lecture Announcement. Please Listen to this audio! Grazie, Dr. Daniel J. Guerra 22.9.21
September 23, 2021 01:09 - 5 minutes - 4.79 MBThis is the link to my new (second in the series) of synoptic Human Aging YouTube lectures. https://youtu.be/IckyMGw8Ffs Please subscribe to both my podcast and YouTube channels! And please contribute! It is the First day of Autumn. Enjoy! --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Interferon I role in autoimmune disease and the corruption of mechanisms that lead to age-related morbidity and mortality.DJGPhD. 22.9.21
September 22, 2021 17:48 - 30 minutes - 27.5 MBInterferons are innate immune agents of inflammation and recovery. Mutations or epigenetic modifications associated with advanced aging may corrupt interferon pathway fidelity involving mitophagy leading to autoimmune disease and morbidity later in life. References Nat Immunol. 2021 Mar; 22(3): 312–321 J Neuroinflammation. 2019; 16: 236. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Aging Immune Response and Cellular Differentiation are characterized by Apoptosis vs. Necroptosis Mechanisms. DJGPhD. 20.9.21.Authentic Biochemistry Productions.
September 20, 2021 21:15 - 30 minutes - 27.5 MBA general audio lecture involving a molecular interactome mediating the innate immune response and the control over T and B lymphocyte memory cells resulting in long term potentiation of autoimmune disease during aging. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Semaphorin works through mToR and thus the abl and AKT kinases in Macrophage reverse switching from lipogenesis to fatty acid oxidation. DJGPhD 18.9.21.
September 19, 2021 00:16 - 29 minutes - 27.3 MBI discuss the complex but potent interactions of TLR signaling with plasma membrane protein complexes including semaphorin cytoplasmic kinase interactions leading to PPAR gamma transcription that fires off CD36 and beta oxidation gene transcription to switch M1 to M2 macrophage polarity thus feedback regulating the pro-inflammatory glycolytic mToRC system dynamics. Aging is associated with a corruption in this fine-tuning that presents in the older sedentary human individual as a simple d...
Macrophage and T lymphocyte Inclusion to the Aging Human Pathobiochemical Phenotype. DJGPhD.Authentic Biochemistry 18.9.21
September 18, 2021 17:49 - 29 minutes - 27.3 MBMacrophage polarization and differentiation works in conjunction with CD4+ T lymphocyte differentiation into Th1 and Th2 subclasses and both NK and B cell activities. The aging human loses feedback control over the pro-inflammatory and anti-inflammatory pathways from these classical cellular differentiations contributing to hyperinflammation and/or hypoinflammatory responses ultimately resulting in pathological cell degeneration or proliferation, morbidity and death. Dr. Daniel J. Guerra Aut...
Invitation to Watch my Youtube lecture I on the Aging Human Dialectic. Link found in the show notes. DJGPhD 16.9.21
September 17, 2021 00:10 - 2 minutes - 1.91 MBhttps://youtu.be/4sW-BNVhzrs --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Membrane Biochemistry Primer and Introduction to Aging. Dr. Daniel J. Guerra. Authentic Biochemistry Productions. 13.9.21
September 13, 2021 21:05 - 29 minutes - 27.4 MBDr. Guerra introduces a primer on membrane biochemistry in preparation for a florid analysis of autophagy and the various forms of programmed cell death linked to the aging human. References Cell Discovery volume 7, Article number: 4 (2021) --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Summer Fades and Aging Advances through non-coding RNA's and the Immunological Axes. Dr Daniel J. Guerra. 9.9.2021 Authentic Biochemistry Productions.
September 09, 2021 21:49 - 29 minutes - 27.3 MBNon coding RNA may regulate melanogenesis and in combination with plasma cell producing IgG the nutritional regulation of satiety. Aging results in alterations of this complex system thus resulting in localized melanogenesis and a corruption of the HPA axis. References: Aging (Albany NY). 2021 Jan 31; 13(2): 2700–2726. Stem Cells Int. 2020; 2020: 1047896. First Published online 2020 Jul 8 PNAS. 2002 Dec 24;99(26):17155-60 --- Support this podcast: https://podcasters.spotify.com/pod/s...
Hepatic Gluconeogenesis and Glycogen Metabolism: Canonical Allostery. Dr Dan Guerra. Authentic Biochemistry 07 Sept. 2021
September 07, 2021 19:51 - 29 minutes - 27.4 MBComponents of metabolic sequence toward gluconeogenesis in the human liver. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The hormonal and allosteric control over hepatic PFK2/FBPase2 via adenylate cyclase and Fructose 2,6 bis phosphate. DJGPhD.5Sept.2021. Authentic Biochemistry Productions.
September 05, 2021 22:54 - 30 minutes - 27.5 MBDr. Guerra details the glucagon and epinephrine mediated control through Stimulatory G-protein couple adenylate cyclase activating PKA over Hepatic Glycolysis and Gluconeogenesis. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Glycerol 3-phosphate dehydrogenase mechanism and the finale of glycolysis. Authentic Biochemistry. Dr. Daniel J. Guerra 27.8.21
August 27, 2021 21:44 - 29 minutes - 27.3 MBUtilization of a protein cysteine SH derived thioester intermediate alters the free energy hurdle for the synthesis of 1,3 bis PGA thus allowing for glycolytic ATP and NADH synthesis. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Haemoglobin: Molecular Oxygen Binding Cooperativity and the role of 2,3 bis phosphoglyceric acid. DJGPhD 19.8.21
August 20, 2021 00:44 - 29 minutes - 27.2 MBThe interaction of glycolysis and lactic acid transport from skeletal muscle to the liver plays a significant role in oxygen uptake, transport and release in association with pulmonary carbon dioxide efflux . Dr. Daniel J. Guerra. An Authentic Biochemistry Production 19.8.21. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
A Necessary Interruption in Amino Acid Catabolism: Haemoglobin and Oxygen Transport Lecture I. DJGPhD. 11 August 2021
August 11, 2021 23:15 - 29 minutes - 27.1 MBAny chronic decrease in the ability for molecular oxygen to bind to circulating Hb will diminish its availability in the Central Nervous System and Skeletal Muscle resulting in the potential for long-term Pathophysiology and Illness. Dr. Dan Guerra Published 11 August 2021. Authentic Biochemistry. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Amino Acid Catabolism (Continued): Neurotransmitter and S-adenosyl MET interconversions. DJGPhD 09 Aug 2021
August 09, 2021 20:50 - 24 minutes - 22.8 MBClassical Amino Acid Degradation Biochemistry : Emphasis on pathway interconversions and production of bioactive amines --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Main Frame Amino Acid Degradation Pathways and Skeletal Muscle Performance and Ammonia Toxicity.02.Aug.2021. DJGPhD. Authentic Biochemistry
August 02, 2021 22:53 - 30 minutes - 27.5 MBJ Physiol. 2005 563:285-90 Eur J Appl Physiol(2011) 111:2837–2843 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Urea Cycle and the endothelial ARGININE-Nitric Oxide Connection. DJGPhD 27.7.21.Authentic Biochemistry Podcast
July 27, 2021 21:28 - 29 minutes - 27.4 MBBiomedicines. 2020 Aug 6;8(8):277. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Glutamate Dehydrogenase Axis Further Reveals the Role of Ischaemic Oxygen Availability for Neural Transmission in the Aging Brain. DJGPhD 20.7.21.
July 20, 2021 22:24 - 29 minutes - 27 MBJournal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Glutamate Axis of Bioenergetics, Neurotransmission and Potential Contribution to the Aging Senescent Phenotype. DJGPhD 20.7.21
July 20, 2021 17:35 - 29 minutes - 27 MBJournal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464) Life Sci . 2019 Sep 1;232:116612 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Amino acid metabolism I: An initial primer for subsequent discussions in Aging. Dr Guerra. 07July2021. Authentic Biochemistry.
July 12, 2021 22:51 - 29 minutes - 26.8 MBThis is one of my classical biochemistry introductory lectures on amino acid utilization. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Mesenchymal stem cell fate and the mediation of age-associated senescence or plasticity in the elderly via immune response valency. DJGPhD 03 July 2021
July 04, 2021 02:20 - 27 minutes - 25.6 MBTrends in Immunology Volume 36, Issue 4, 2015, 217–228 Carcinogenesis 2015;36:1180-1192 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Detailing the Senescent to Mesenchymal Transition in Aging : Links to Cancer vs. Apoptosis. DJGPhD 28 June 2021.
June 28, 2021 22:45 - 29 minutes - 27.1 MBClinical and Molecular Allergy volume 15, Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Genomic damage, DDR, and the roles of inflammation and DNA epigenetic retailoring in the senescent phenotype. DJGPhD 24.6.21
June 25, 2021 02:34 - 29 minutes - 26.9 MBOncotarget. 2013 Oct; 4(10): 1552–1553 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Pharmacodynamics: General Considerations and Clinical Trials. Dr. Dan Guerra. Authentic Biochemistry 12 June 2021
June 12, 2021 23:11 - 29 minutes - 27.2 MBIn this episode Dr. Guerra provides the overview of Pharmacodynamics . --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Pharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.
June 10, 2021 02:44 - 29 minutes - 27.1 MBA.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support! --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Cardiovascular disease risk and malnutrition are associated with aging morbidity and obesity. Dr. Guerra. 8 June 2021. Authentic Biochemistry
June 08, 2021 22:49 - 28 minutes - 26.5 MBRisk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization. The immune response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restricting oxygen intake. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-...
Ceramide mediated pathophysiology of aging-associated neurodegeneration. Dr. Dan Guerra. Authentic Biochemistry.05 June 2021.
June 05, 2021 22:07 - 28 minutes - 25.7 MBSeminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126 Pharmaceutical Research March 2018, 35:49 Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182 J. Lipid Res. 2018 59:(3) 488-506. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry.
June 03, 2021 23:26 - 29 minutes - 27.2 MBFeng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Aging and Cancer Via Immunosenescence and Pro-inflammatory Cytokines: Relative loss of Naive T cell Populations in the Elderly. DJGPhD. 26 March 2021
May 26, 2021 23:09 - 29 minutes - 27.4 MBAnnu. Rev. Physiol. 2013. 75:685–705 Nutrients. 2020 Mar; 12(3): 622 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Pathobiochemical linkages between Alzheimer's Disease and Autism Spectrum Disorders: Associative Molecular Patterns with Diverse Pathologies. DJGPhD. 18 May 2021
May 19, 2021 02:06 - 29 minutes - 27.3 MBFASEB J. 2013 Jun; 27(6): 2458–2467. Scientific Reports volume 7, Article number: 13763 (2017) --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Immunomodulatory effects on neuropsychiatric states: classic rodent model studies. Dr. Guerra. 17.5.21 Authentic Biochemistry
May 18, 2021 01:19 - 29 minutes - 26.6 MBScientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12 Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221 Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article number: 13763 (2017) --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-...
Linking TLR's with the VTA and NE circuitry: Immune mediated neurodegeneration and neuroprotection in the balance. DJGPhD 16 May 2021
May 17, 2021 01:24 - 29 minutes - 27.3 MBBrain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
May 14, 2021 00:11 - 30 minutes - 27.5 MBTLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun. 2019 Oct;81:41-51 J Mol Neurosci. 2021 Mar 9 --- Support this podcast: https://podcasters.spot...