Latest Biotechniques Podcast Episodes
Spatial analysis of the immune-cell-surface proteome at a single-cell resolution
Talking Techniques - March 22, 2024 14:21 - 23 minutesThe cell-surface proteome plays a critical role in immune-cell function; however, our ability to examine its interactions and spatial organization has previously been limited by available proteomic techniques. This episode explores the function of immune-cell membrane proteins and how the latest...
Investigating the neurological pathways underlying vocal communication
Talking Techniques - February 20, 2024 15:44 - 34 minutesIn this episode of Talking Techniques, we catch up with Michael Long, Principle Investigator of the Long Lab at New York University (NY, USA), where he investigates the neural circuits that underlie vocal communication. Through the examination of animal models, from songbirds to the rare singin...
Rare disease and pharmacogenomics
Talking Techniques - January 23, 2024 10:26 - 20 minutesLaunching our fourth season of Talking Techniques, this episode, supported by the University of Cincinnati (OH, USA) we delve into rare disease research and pharmacogenomics, their intersection and the key techniques used to explore them. Guiding us through these fields is Brenna Carey, an Assi...
One man’s waste in another man’s treasure: using wastewater to monitor infectious diseases
Talking Techniques - December 18, 2023 09:57 - 20 minutesIn this episode of Talking Techniques, we talk to Andrew Lee, a senior research fellow in Queen’s University Belfast’s (UK) wastewater-based epidemiology group, about his work using wastewater to monitor and detect infectious diseases. Andrew discusses how wastewater surveillance acts as an earl...
Talking Techniques | One man’s waste in another man’s treasure: using wastewater to monitor infectious diseases
Talking Techniques - December 18, 2023 09:57 - 20 minutesIn this episode of Talking Techniques, we talk to Andrew Lee, a senior research fellow in Queen’s University Belfast’s (UK) wastewater-based epidemiology group, about his work using wastewater to monitor and detect infectious diseases. Andrew discusses how wastewater surveillance acts as an earl...
Next-generation antibody therapeutics
Talking Techniques - November 22, 2023 17:18 - 24 minutesIn this episode of Talking Techniques, we speak to two experts from Sino Biological US Inc. (PA, USA) about the latest developments in antibody technologies and how these developments have led to the next generation of antibodies that are revolutionizing therapeutic approaches to a number of dis...
Investigating resistant leukemia with single-cell technologies
Talking Techniques - November 03, 2023 16:20 - 9 minutesIn this episode of Talking Techniques, Rachel Thijssen, an Assistant Professor at Amsterdam University Medical Centers (UMC; the Netherlands), discusses her research using single-cell analyses to investigate treatment-resistant leukemia cells. Rachel explains her single-cell technique called rap...
Talking Techniques | Investigating resistant leukemia with single-cell technologies
Talking Techniques - November 03, 2023 16:20 - 9 minutesIn this episode of Talking Techniques, Rachel Thijssen, an Assistant Professor at Amsterdam University Medical Centers (UMC; the Netherlands), discusses her research using single-cell analyses to investigate treatment-resistant leukemia cells. Rachel explains her single-cell technique called rap...
CAR-T and CAR-NK cell therapies
Talking Techniques - July 27, 2023 13:38 - 27 minutesIn this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also ad...
Talking Techniques | CAR-T and CAR-NK cell therapies
Talking Techniques - July 27, 2023 13:38 - 27 minutesIn this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also ad...
Mitochondria, the immune system and cancer: discovering new insights with spatial technologies
Talking Techniques - June 16, 2023 15:30 - 24 minutesIn this episode, supported by Fortis Life Sciences, we delve into the relationship between mitochondria, inflammation and cancer, discussing the new techniques that are bearing fruit in this field, such as spatial analysis. Our expert insight for this episode comes from Phillip West, Principle ...
Long-read sequencing, metagenomics and the microbiome
Talking Techniques - May 10, 2023 13:42 - 22 minutesIn this episode, sponsored by Zymo Research, we explore the microbiome and how long-read sequencing techniques are changing our approach to the field and the exciting discoveries that they have led to. To do this we speak to Kris Locken, Molecular Biologist in the Research & Development departme...
Open neuroscience and the meaning of FAIR
Talking Techniques - February 03, 2023 12:52 - 37 minutesThis episode, our second recorded at Neuroscience 2022 (13-19th April 2022; San Diego, CA, USA), delves into the importance of open data in neuroscience and the FAIR guidelines, which encourage researchers to make their data Findable, Accessible, Interoperable and Reusable. Sharing her consider...
Welcome to the jungle: sequencing for conservation
Talking Techniques - January 25, 2023 14:43 - 43 minutesIn this episode of Talking Techniques, we head to the Ecuadorian rainforest to chat about the use of sequencing in conservation with Zane Libke, a field researcher based at Sumak Kawsay In Situ (Pastaza, Ecuador). Zane discusses how he turned his fascination with nature into a career, his curren...
Neuropixels: big data heaven or burying the lead in averages?
Talking Techniques - January 18, 2023 10:40 - 19 minutesIn this special episode of Talking techniques, one of two recorded at Neuroscience 2022, we speak to Tim Harris (Howard Hughes Medical Institute, VA, USA). Tim is the creator of Neuropixels, neural recording probes inserted into the brains of animal models, which allow researchers to collect sig...
Microbiome profiling techniques: from immunology to agriculture
Talking Techniques - September 29, 2022 15:59 - 22 minutesIn this episode of the Talking Techniques podcast, we explore microbiomes and the techniques used to profile them. Get an overview of the different techniques’ working principles, their pros and cons and the different applications that they are best suited to. Providing an expert insight into t...
The gut–brain axis and addiction
Talking Techniques - September 28, 2022 10:38 - 29 minutesIn this special episode of Talking Techniques, brought to you from the Federation of European Neuroscience Societies Forum (FENS; 9th–13th July 2022), an expert panel discuss their research into the relationship between the gut–brain axis and addiction. The panel features Benjamin Boutrel (Laus...
3D cell cultures: the latest developments, applications and regulations in the field
Talking Techniques - August 26, 2022 09:40 - 30 minutesIn this episode, supported by BrandTech, returning guest Rob Vries, CEO of HUB organoids (Utrecht, The Netherlands), fills us in on the advancement of 3D cell cultures and organoids over the last 2 years, starting off by documenting how the pandemic impacted their development and uptake. We als...
rAAVs, host-cell contamination and ddPCR
Talking Techniques - August 03, 2022 14:54 - 26 minutesIn this episode of Talking Techniques, supported by Bio-Rad, we discuss a key component of many gene therapies: recombinant adeno-associated viruses (rAAVs) and their production. These viruses act as efficient, accurate delivery vesicles for the gene therapy’s plasmid. Speaking to Associate Dir...
HPV, epigenetics and cancer: sequencing for new insights and to correct healthcare inequality
Talking Techniques - July 28, 2022 14:00 - 17 minutesIn many regions of the world, HPV and its association with cervical cancer is a well-known but rarely considered issue, after the rollout of the HPV vaccine in the late 2000s. However, while this rollout significantly impacted cervical cancer rates where it was implemented, it was not universal ...
Artificial intelligence in healthcare
Talking Techniques - July 20, 2022 08:43 - 30 minutesRecently, the Alliance for Artificial Intelligence in Healthcare (AAIH) published "The Lifecycle of an AI System in Healthcare", a whitepaper defining what healthcare is and provides guidelines on implementing artificial intelligence (AI) and machine learning (ML) in this setting. In this episo...
Liquid biopsy and cfNAs: driving forward diagnostics and disease research
Talking Techniques - May 26, 2022 10:29 - 22 minutesThe key diagnostic and prognostic information locked away in cell-free nucleic acids (cfNAs) has become increasingly accessible due to developments in genetic and epigenetic profiling techniques. These advances have engendered the rise of liquid biopsy techniques, which capture and analyze cfNAs...
The evolution of recombinant antibodies
Talking Techniques - April 19, 2022 17:30 - 17 minutesIn this episode, we discuss recombinant proteins: what are they and what are they used for? BioTechniques Editor Tristan Free speaks to Amy Sheng, Technical Account Manager at Sino Biological, who explains the history of recombinant proteins and how protein modeling techniques such as AlphaFo...
The epigenetic clock
Talking Techniques - March 25, 2022 12:17 - 24 minutesIn this episode, supported by Zymo Research, we discuss the epigenetic clock: what is it? How are researchers using it and what are some of the key tools available to study it? Elucidating the link between epigenetics and aging is Keith Booher, Director of Services at Zymo research including a...
Resolving spatial biology in neuroscience
Talking Techniques - February 28, 2022 16:24 - 30 minutesIn this episode of Talking Techniques, supported by Resolve BioSciences, we explore the realm of spatial biology, with a particular focus on the techniques involved in this approach to biological exploration, and the exciting insights gleaned from these techniques that have led to this approach ...
Introducing STEM Tea
Talking Techniques - February 17, 2022 12:11 - 34 minutesIn this episode of Talking Techniques, we introduce a new podcast series, produced by BioTechnques and hosted by the enigmatic Antentor Othrell Hinton Jr, Assistant Professor of Molecular Physiology and Biophysics at the Vanderbilt University (TN, USA), and bring you a sneak peek of the first ep...
Cell proliferation in drug screening
Talking Techniques - January 25, 2022 16:33 - 20 minutesIn this episode, supported by BioRad, we explore cell proliferation monitoring and its role in drug discovery, guided by the expert advice of Rachel Preston, Product Development researcher at Bio-Rad. We discuss techniques available to monitor cell proliferation, their advantages and disadvant...
Synthetic biology: from cancer to the climate crisis
Talking Techniques - December 21, 2021 12:15 - 26 minutesIn this episode, we explore the field of synthetic biology. Discover the history of the field and its origins in the production of biofuels, before fracking burst onto the scene forcing a pivot in direction towards chemical production. Find out about the key techniques that have brought syntheti...
Establishing an epigenetic lens to explore cancer and infectious diseases
Talking Techniques - November 12, 2021 14:37 - 23 minutesWe are talking all things DNA methylation in this episode, providing a brief explanation of epigenetics and the technologies involved in the study of DNA methylation, before exploring the application of these techniques in the study of infectious diseases and cancer. Revealing all of this info...
Target enrichment for NGS: why, how and what's next?
Talking Techniques - October 26, 2021 13:26 - 18 minutesIn this episode, supported by Roche, we explore a vital aspect of many next-generation sequencing studies: target enrichment. Here, regions of interest are selectively amplified before sequencing takes place. More specifically we examine some of the new technologies improving this key step and t...
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