Authentic Biochemistry
765 episodes - English - Latest episode: 1 day ago - ★★★★★ - 10 ratingsBecome a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
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Episodes
BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis
September 09, 2023 01:20 - 30 minutes - 27.8 MBReferences Cells. 2022 Mar; 11(6): 997. Nat Cell Biol. 2019 Mar; 21(3): 397–407. Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23
September 08, 2023 01:27 - 30 minutes - 27.8 MBReferences Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620 Science Immunology.2018.26 Jan Vol 3, Issue 1. Nature. 2020 Jun; 582(7813): 577–581. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry.
September 07, 2023 18:26 - 30 minutes - 27.8 MBReferences Nature. 2020 Jun; 582(7813): 577–581 Science Immunology 2018.26 Jan Vol 3, Issue 1 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast.
September 05, 2023 19:33 - 30 minutes - 27.8 MBReference The Journals of Gerontology: 2019. Series A,Volume 74, Issue 12, Pages 1887–1895 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry.
September 03, 2023 20:16 - 29 minutes - 27.7 MBReferences Endocrinology. 2012 Jun; 153(6):2544–2550. Redox Biol. 2020 Apr; 31: 101482 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD.
September 02, 2023 21:53 - 30 minutes - 27.8 MBReferences Lipids 3 May 2022. Volume57, Pages 183-195 Front Immunol. 2023; 14: 1116839 Mol Metab. 2022 Aug; 62: 101523 Nature Reviews Molecular Cell Biology 2018. volume 19, pages 175–191 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23
August 31, 2023 23:50 - 29 minutes - 27.7 MBReferences Aging (Albany NY). 2019 Jan 15; 11(1):73–88. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast.
August 30, 2023 23:45 - 29 minutes - 27.6 MBReferences Front. Endocrinol.2015 Sec. Clinical Diabetes Obes Sci Pract. 2017 Mar; 3(1): 106–114. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast
August 29, 2023 19:36 - 29 minutes - 27.7 MBReference BMC Genomics. 2022; 23: 519 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link
August 28, 2023 05:39 - 1 minute - 1.51 MBhttps://youtu.be/llYhGi1XSvU --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23
August 24, 2023 23:47 - 30 minutes - 27.8 MBReferences Scientific Reports 2015.volume 5,Article number: 15292 Dev Cell. 2023 Apr 10;58(7):597-615.e10 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23
August 23, 2023 00:29 - 30 minutes - 27.8 MBReferences Genes & Immunity 2021. volume 22, pages 125–140. Prz Menopauzalny. 2017 Jun; 16(2):51–56. J Neuroinflammation. 2016 May16;13(1):109. Am J Physiol Cell Physiol 2022. 322: C125–C135 Adv Human Genetics 1983.13:83 Ann NY Acad Sci . 1986. 477:129 Neurol Neurosurg Psychiatry.1943. 6:154 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation
August 21, 2023 20:40 - 29 minutes - 27.7 MBReference J Hum Evol. 2022 Oct; 171: 103229. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23
August 19, 2023 00:29 - 30 minutes - 27.8 MBReferences Immunity 2021. 54, 2273–2287 Front Immunol. 2020. 11: 784 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.
August 18, 2023 21:53 - 29 minutes - 27.7 MB__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD
August 17, 2023 18:29 - 29 minutes - 27.7 MBReferences Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry
August 16, 2023 19:01 - 30 minutes - 27.8 MBReferences Histol Histopathol. 2018 Jan; 33(1): 1–10 J Steroid Biochem Mol Biol. 2022Feb;216:106040 Steroids. 2022 Sep;185:109053 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.
August 14, 2023 23:17 - 30 minutes - 27.8 MBReferences J Steroid Biochem Mol Biol. 2022. Feb;216:106040. Steroids. 2022 Sep;185:109053 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23
August 14, 2023 19:28 - 28 minutes - 26.5 MBReferences Alzheimer's Research & Therapy 2021. volume13, Article number: 56. Progress in Molecular Biology and Translational Science 2019. Volume 168 # --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD
August 13, 2023 03:45 - 29 minutes - 27.8 MBReferences Genes & Immunity 2021 volume 22, pages 125–140 Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87 Essays Biochem. 2021 Nov; 65(6): 913–925 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.
August 11, 2023 22:22 - 29 minutes - 27.7 MBReference Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD
August 09, 2023 23:40 - 29 minutes - 26.9 MBReferences Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670 Brain Res. 2009 Sep 22; 1290: 1–11. JAMA.2003;289(20):2651-2662. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.
August 08, 2023 01:27 - 29 minutes - 27.7 MBReferences JAMA.2003;289(20):2651-2662. Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Psychiatry. 2019 Sep 15;86(6):421-432 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection.
August 07, 2023 01:11 - 29 minutes - 27.8 MBReferences Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23
August 05, 2023 23:31 - 29 minutes - 27.8 MBReference Essays Biochem. 2021 Nov; 65(6): 913–925 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23
August 05, 2023 19:39 - 30 minutes - 27.8 MBReferences Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Sex Differ. 2023; 14: 34. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry
August 03, 2023 22:33 - 30 minutes - 27.8 MBReferences Biol Sex Differ. 2023; 14: 34 J Cell Sci 2005;118:4605-4612 EBioMedicine. 2015 Dec; 2(12): 1888–1904 PLoS Genet. 2013 Jun; 9(6): e1003556 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast
July 31, 2023 01:04 - 29 minutes - 27.3 MBReference Some light on the forest floor of wisdom --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast
July 30, 2023 23:36 - 30 minutes - 27.8 MBReferences Experience et al. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry
July 30, 2023 02:00 - 29 minutes - 27.3 MBReferences Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast.
July 28, 2023 23:16 - 30 minutes - 27.8 MBReference Front Immunol.2022; 13: 890056. previous IE lectures 1-3. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD
July 27, 2023 00:09 - 29 minutes - 27.3 MBReference Cancers (Basel). 2021. Apr; 13(8): 1850. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression.
July 26, 2023 01:04 - 29 minutes - 27.8 MBReferences NPJ Vaccines. 2018; 3: 23. Immunol Cell Biol. 2022 Aug; 100(7): 562–579 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23
July 24, 2023 21:02 - 29 minutes - 27.7 MBReferences Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23
July 23, 2023 17:17 - 29 minutes - 27.1 MBReferences J Immunol. 2014 Aug 15; 193(4): 1531–1537 Immunology lecture notes-Guerra --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast.
July 23, 2023 01:25 - 29 minutes - 27.3 MBInspirations A hot summer day and what passes as a ponder on the asymmetric. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23
July 20, 2023 21:36 - 29 minutes - 27.7 MBReference Immunol Cell Biol. 2022 Aug; 100(7):562–579. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry
July 20, 2023 00:48 - 28 minutes - 26.4 MBReference Immunol Cell Biol. 2022 Aug; 100(7):562–579. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA.
July 19, 2023 01:17 - 30 minutes - 27.8 MBReferences Signal Transduction and Targeted Therapy 2021.volume 6, Article number: 412. Nature Immunology. 2022. volume 23, pages 1208–1221. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD.
July 17, 2023 23:12 - 30 minutes - 27.8 MBReferences J Biol Chem. 2021 Jul;297(1):100900 Immunol Rev. 2014 May; 259(1):88–102. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry.
July 15, 2023 23:21 - 29 minutes - 27.8 MBReference Nature Immunology 2022. volume 23, pages 1208–1221. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry
July 11, 2023 23:56 - 29 minutes - 27.1 MBReferences Nature Immunology 2022. volume 23, pages 1208–1221 Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast.
July 10, 2023 01:37 - 29 minutes - 27.6 MBReferences Guerra lectures archives --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions
July 09, 2023 17:07 - 30 minutes - 27.8 MBDr Guerra lecture notes --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast.
July 09, 2023 00:42 - 29 minutes - 27.8 MBReferences Guerra's plant biochemistry lectures --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July
July 08, 2023 17:55 - 30 minutes - 27.8 MBReferences Plant Biochemistry lectures archives :Guerra Phys.Chem. Chem. Phys., 2020,22, 7912-7934 Nature Plants 2017. volume 3, Article number:17041 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions
July 06, 2023 17:58 - 29 minutes - 27.7 MBGuerra: Plant biochemistry Lectures --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production.
July 05, 2023 22:13 - 30 minutes - 27.8 MBReferences Plant Biochemistry Lectures -Guerra --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast.
July 05, 2023 18:23 - 30 minutes - 27.8 MBReferences Guerra. Plant Biochemistry lectures --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions)
July 04, 2023 01:59 - 29 minutes - 27.7 MBReference Organic chemistry : reaction mechanism lectures --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support