You Cannot Be Depressed And Grateful at the Same Time. Gratitude is a gift not only to others, but to yourself as well. The mad mind constantly tries to find what's wrong with life, with others and with the day It filters out the beauty and joy, dwells on pain and disappointment and tries to take over our lives. Gratitude is a powerful medicine for all that ails us. Take charge of your focus. Seek out that which is beautiful, brave, beneficial in all you meet. It only takes a moment. Rather than dwell upon how you've been disappointed, dwell upon what you've learned or gained from this interaction. Give Thanks all day long. Happy holiday.