IS PHARMACOLOGY DIFFICULT®️ Podcast
316 episodes - English - Latest episode: about 1 month ago - ★★★★★ - 2 ratingsWelcome all to "Is Pharmacology Difficult®️ podcast ". This is a Pharmacology podcast !! I am your host, Dr Radhika Vijay, M.B.B.S., M.D. Pharmacology, Sardar Patel Medical College, Bikaner, Rajasthan, India. Pharmacology (medical sciences) is my subject and I think Communicating about it to the masses is very essential. It is of great value and importance to every layman. The episodes here will be in simple English language (with few phrases and add ons of my favourite french language). The basic motto is to create an awareness and impart knowledge of the subject to all interested, concerned, curious and visitors. Pharmacology, the "SCIENCE OF DRUGS", which hold an important place in everyone's life. Here, I will discuss basic tips, strategies and ideas to study medical pharmacology easily and effectively especially for medical, nursing, dental and pharmacy schools and students. Even if you are not from Science stream, this information would be beneficial to you and therefore pay some valuable minutes to this Pharmacology Podcast, and you will not be in loss !! The descriptions will be short pieces of science work lengthy enough to engage you and not to test your patience! So, go ahead, lend your ears to these crispy informative audio files and empower and enrich your sea of knowledge and let me know "IS PHARMACOLOGY DIFFICULT?" For various links, please visit: https://linktr.ee/ispharmacologydifficult. Disclaimer: All the content of the podcast audio is expressed in my own language and learning and understanding viewpoints. References are from the best and reputed subject (Pharmacology) text books, blogs, journals and drug information from reputed and best online sources. I make best efforts to convey the most accurate and updated information of the subject of medical sciences in my special way. I take no money from pharmaceutical industry or drug companies for my podcast. You are most welcome to post your comments, suggestions, etc. through "Contact" page on my website: www.ispharmacologydifficult.com. You all are well known that medical sciences subjects are ever changing, updated and ever evolving, hence no guarantee is taken if the information conveyed in this podcast turns outdated or obsolete with changing and evolving times. This podcast is an expression of my learnings and experiences and in no way representative of any standard authority. Privacy Notice: I collect only email addresses of the subscribers and in no circumstances they will be shared or displayed anywhere on podcast/website/newsletter. Copyright & Distribution: All the contents of "IS PHARMACOLOGY DIFFICULT®️" podcast/website/blog/newsletter are copyrighted. Though all the content related to podcast and various social media handles is free! "BUT" in no way or under no circumstances shall- Any of the podcast content/show notes/blog post/newsletter content/youtube video artwork/podcast artwork and ideas should be used or reproduced or distributed.
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Episodes
Is Pharmacology Difficult Podcast TRANSPORTERS OF DRUGS
September 06, 2020 13:30 - 4 minutes - 3.34 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode I will try to fit in some round pegs in between square holes of our ongoing topic from so many days, let us have a break, some change, a pause for deep breath and today's point of discussion will rotate around Transporters of Drugs, their implications in drug disposition and disease. Though seeming a different way out of current streams of topics, its very very relevant at present spot. I will be tel...
Is Pharmacology Difficult Podcast NON ENZYMATIC BIOTRANSFORMATION (HOFFMAN ELIMINATION)
September 05, 2020 13:30 - 5 minutes - 3.76 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, firstly wishing all a very Happy Teacher's Day ! Quickly coming over to the topic, I will be first giving you all 5 facts for 5th September, First fact states that most drugs are metabolised by multiple pathways, which may be occurring simultaneously or sequentially, depending on time and process, second fact is again about rate of metabolism, third fact is all about the metabolites, fourth fact is ...
Is Pharmacology Difficult Podcast NON MICROSOMAL SYNTHETIC REACTIONS-2
September 03, 2020 13:30 - 5 minutes - 3.92 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, firstly I will be discussing the Glycine conjugation reactions, whatever we did yesterday and today, all are Non Microsomal Synthetic reactions, Glycine conjugation is a minor metabolic pathway, then I will talk about a very important synthetic reaction i.e. Glutathione Conjugation reactions, it inactivates highly reactive quinone or epoxide intermediates, wonderful example is paracetamol, which lead...
Is Pharmacology Difficult Podcast NON MICROSOMAL SYNTHETIC REACTIONS -1
September 02, 2020 12:30 - 5 minutes - 3.78 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, I am Dr Radhika Vijay, in today's episode, I will be sharing a funny thought about knowledge, discussing about tomato, but without delay I will come to the topic, i.e.more of Synthetic reactions like three in number for the day, first one being Acetylation reactions occurring in cytosol. They are catalysed by N-Acetyl transferases and the drugs undergoing these reactions show genetic polymorphism, and the person can be slow or fast acetylator...
Is Pharmacology Difficult Podcast GLUCURONIDE CONJUGATION OF DRUGS AND ENTEROHEPATIC CYCLING
September 01, 2020 15:30 - 8 minutes - 5.7 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be starting the good gracious deed of mine with the description of Microsomal Conjugations, and only example is Glucuronide Conjugation, The phase 1 metabolites with special groups undergo these reactions, catalysed by microsomal UGTs, yielding dug- glucuronide conjugates, This is most important synthetic reactions, examples of drugs undergoing these reactions are aspirin, paracetamol, chlora...
Is Pharmacology Difficult Podcast PHASE 2 REACTIONS INTRODUCTION
August 31, 2020 13:30 - 4 minutes - 3.2 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, I am Dr Radhika Vijay and in today's episode firstly I will break my own set myth of manic mondays and will see the other side of the coin as when we dip mondays gifted to us in glitter we can sparkle all day, isn't the thought brilliant? well , heading on to the topic I want to state that Phase 2 reactions also well famous as Conjugation or Synthetic reactions , they involve conjugation with polar endogenous molecules which are intermediary...
Is Pharmacology Difficult Podcast HYDROLYSIS, CYCLIZATION, DECYCLIZATION REACTIONS
August 30, 2020 14:30 - 5 minutes - 4.02 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay , in today's episode I advise you all to count your rainbows and not your thunderstorms on a happy sunday , with this positivity we commence today's episode with the basic equation of Hydrolysis reaction and get to know as to ester plus water molecule gives rise to acid plus alcohol in presence of esterases, then I will be telling you about some other enzymes, the different sites of hydrolytic reactions, then I will b...
Is Pharmacology Difficult Podcast NON MICROSOMAL OXIDATIONS AND REDUCTION REACTIONS
August 29, 2020 14:30 - 5 minutes - 3.73 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will light the candle of knowledge with a beautiful quotation of George Eliot which states that, "There are so many things that one can do with a new person and that is becoming a better man too", with this, I will break the ice of today's episode with the heading of Non Microsomal Oxidation Reactions, in this first comes the Mitochondrial oxidations, then Cytoplasmic oxidations and finally to acc...
Is Pharmacology Difficult Podcast MICROSOMAL OXIDATION REACTIONS
August 28, 2020 15:30 - 6 minutes - 4.72 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, first of all, a news from my end to share, Its my son's birthday and we gonna do a home based celebration, quite limited and restricted in nature, in today's episode I will be covering Phase 1 reactions , especially oxidation reactions, in these firstly I will talk about microsomal oxidations which are CYP dependent and in these first and foremost to talk about are aromatic hydroxylations, then come aliphatic hydroxyla...
Is Pharmacology Difficult Podcast NON MICROSOMAL ENZYMES
August 27, 2020 14:30 - 5 minutes - 3.61 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay and in today's episode, we will trail through the nick of CYP isoenzymes, their connection and variability as far as interspecies and inter individual differences are concerned, few groups of drugs as examples are barbiturates, phenothiazines, imipramine, propranolol, etc. Then I will throw some light on few drugs metabolised by group of flavin mono oxygenases, then what you ought to know is how the latter differ from C...
Is Pharmacology Difficult Podcast DRUG METABOLISING ENZYMES -3
August 26, 2020 13:30 - 7 minutes - 5.4 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode I will be continuing my talk on Drug Metabolising enzymes, i.e. few more CYP isoenzymes and I will commence today's celebrated speech with the CYP2D6, its next most common isoform after CYP 3A4/ 3A5, Its most important reaction is conversion of codein to morphine and human subjects may be extensive or poor metabolisers of this isoenzyme and that may affect codein action, next in list are CYP2C8/2C9 i...
Is Pharmacology Difficult Podcast DRUG METABOLISING ENZYMES -2
August 25, 2020 12:30 - 6 minutes - 4.36 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be talking about the different CYP isoenzymes, first of all covering the common ones, the most important ones in humans, how much they are, where they are found, the common sites..then I will list a few of them, really to know, not to remember though! And then I will narrating the essence of CYP 3 families most important in human bodies, which you ought not only to know, but memorise too! And...
Is Pharmacology Difficult Podcast DRUG METABOLISING ENZYMES INTRODUCTION
August 24, 2020 13:30 - 5 minutes - 3.88 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be verbally and musically painting the introduction to Drug Metabolising Enzymes, firstly telling the group which is Mixed Function Oxidases (MFOs), also called as cytochrome-P450 heamoproteins. This is followed by an explanation of how it gets the name cytochrome P450, then I will be listing few characteristics of microsomal enzymes, that these are non specific in action, they metabolise onl...
Is Pharmacology Difficult Podcast BIOTRANSFORMATION PHASE 1 REACTIONS
August 23, 2020 15:30 - 5 minutes - 3.61 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay and in today's episode I will communicate about especially Phase 1 reactions , also known as Nonsynthetic or Functionalisation reactions. The most important of the different phase 1 reactions amongst oxidation, reduction and hydrolysis reactions are oxidation reactions, they are carried out by Mixed functional oxidases enzyme group, abbreviated as MFO Enzymes. The most important of these is large superfamily of heamprot...
Is Pharmacology Difficult Podcast TYPES OF BIOTRANSFORMATION REACTIONS
August 22, 2020 14:30 - 6 minutes - 4.38 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay , in today's episode I will be communicating about the different types of Biotransformation reactions, the first one known by these names- Non synthetic or Phase 1 or Functionalization Reactions, having a solid reason to be called so, as a new functional group is introduced rendering the drug to polar or non polar metabolites, mainly microsomal in nature, the resultant metabolite may become active or inactive. Such react...
Is Pharmacology Difficult Podcast BIOTRANSFORMATION OF DRUGS CONSEQUENCES-2
August 21, 2020 15:30 - 7 minutes - 4.92 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and in today's episode, we will break the ice by touching the untouched , some leftovers of last night dinner taste good in today's breakfast will be our strategy and I will be quickly revising the definition of Metabolism, I will define its goal i.e. drug excretion by converting to water soluble form, though exceptions are always found, then I will throw some light on two of the common pathways first being reducing lip...
Is Pharmacology Difficult Podcast BIOTRANSFORMATION OF DRUGS CONSEQUENCES
August 20, 2020 14:30 - 5 minutes - 4.02 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be talking about the consequences of biotransformation of drugs, limiting the talk to only two of the three consequences! First one being inactivation of active drug, which actually means termination of action of the drug and Second one being the opposite, that is activation of inactive drug and there is a special name for that inactive drug , its called the PRODRUG!! That is how we get the de...
Is Pharmacology Difficult Podcast BIOTRANSFORMATION OF DRUGS INTRODUCTION
August 19, 2020 13:30 - 3 minutes - 2.5 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, and in today's episode I will be doing a chit chat about Biotransformation of Drugs Introduction, it states that although the onset of drug effect is determined by processes like absorption and distribution, it cannot be tolerated that its action is prolonged for time indefinite, it has to call to halt, and that is done by biotransformation, excretion and upto some extent redistribution. So, it is a very important proc...
Is Pharmacology Difficult Podcast REDISTRIBUTION OF DRUGS
August 18, 2020 15:30 - 3 minutes - 2.5 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, am Dr Radhika Vijay, and in today's episode, I will be getting heart to heart about a short length , quick, fast topic known as Redistribution. Its as quick as a flash of light!! Yes, an appropriate similie to describe this special type of distribution process. So, with some fast acting drugs like thiopentone sodium given intra venously, then oral nitrazepam and few more in the list tells this quick, flashy tale of redistribution process. I ...
Is Pharmacology Difficult Podcast APPARENT VOLUME OF DRUG DISTRIBUTION
August 17, 2020 12:30 - 8 minutes - 6.08 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode I will be collecting messages from sea shells as we together walk through the shores of knowledge, First shell tells us that passage of drug across the membranes and capillary walls depends on lipid solubility which in turn determines the volume of distribution. Second pearl of knowledge states that high or low plasma protein binding determines the volume of distribution and also determines where a dr...
Is Pharmacology Difficult Podcast APPARENT VOLUME OF DISTRIBUTION INTRODUCTION
August 16, 2020 15:30 - 5 minutes - 4.05 MBWelcome to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be introducing the Apparent Volume of Distribution , no more a teaser, today is narrated the introduction finally. Building up a story background for the real concept, I have explained an example of Digoxin, which eventually leads us to the word "APPARENT" and then to volume of distribution, which is actually apparent concept, then going deeper, I will be deriving a proper equation for mathematica...
Is Pharmacology Difficult Podcast IMPORTANT CLINICAL ASPECTS OF PLASMA PROTEIN BINDING-3, HAPPY INDEPENDENCE DAY!!
August 15, 2020 07:30 - 4 minutes - 3 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, wrapped up in spirit of freedom and independence, with all respect, gratitude for our freedom fighters, I will be talking about the final important clinical aspect of plasma protein binding as to how and why the disease, conditions of physiological stress and pathological states affect the plasma protein binding upto a level significant clinically. In this I will talk about the conditions renal failure, liver disease l...
Is Pharmacology Difficult Podcast IMPORTANT CLINICAL ASPECTS OF PLASMA PROTEIN BINDING-2
August 14, 2020 14:30 - 8 minutes - 5.55 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode our plane will take off with full zest and fun and land in beautiful ground of Plasma protein binding where we will take our steps further ahead..I will be commencing today's episode with the fact that drug binds to multiple sites on albumin and multiple drugs bind to same site(s). All this leads to a lot of displacement drug interactions of which final outcome depends on grade of affinity of the drug...
Is Pharmacology Difficult Podcast IMPORTANT CLINICAL ASPECTS OF PLASMA PROTEIN BINDING-1
August 13, 2020 14:30 - 7 minutes - 5.04 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, still standing firm, not hanging on the staircase of Plasma protein Binding. Today's celebrated title goes like the Important Clinical Aspects of Plasma Protein Binding. As we head on in this direction point by point, we start with the fact that highly protein bound drugs are restricted to vascular compartment, having lower volumes of distribution. I will be giving a tabular format of highly bound drugs to albumin as we...
Is Pharmacology Difficult Podcast PLASMA PROTEIN BINDING-3
August 12, 2020 12:30 - 4 minutes - 3.07 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets climb a step more the ladder of Plasma protein binding, yesterday the step took us to the room of Albumin, and today's the turn of alpha1- acid glycoprotein . In this room, we will find other proteins too like tissue proteins, nucleoproteins, and lastly miscellaneous proteins like transcortin, gamma globulins and alpha globulins. You studious listeners should not be amazed by so many plasma proteins, rathe...
Is Pharmacology Difficult Podcast PLASMA PROTEIN BINDING-TO ALBUMIN
August 11, 2020 11:30 - 4 minutes - 3.15 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode I will take a step ahead in stairs of plasma protein binding and give you more jewels of information, Firstly we will get to learn about basic concepts that acidic drugs bind mainly to Albumin, then next step is to know about Albumin as to its molecular net charge, then how it binds basic drugs so much in amount and then readily release them, making it high capacity and low affinity, while its totally...
Is Pharmacology Difficult Podcast PLASMA PROTEIN BINDING INTRODUCTION
August 10, 2020 11:30 - 4 minutes - 3.24 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! As I promised yesterday, I am here with a brand new type of barrier and the topic goes as Plasma Protein Binding. Today is simply the Introduction to this important, extensive and must to be understood topic. Firstly comes the background description which explains that drug partly exists in free form and partly in bound form! But these two forms always exist in dynamic equilibrium and in a sort of reversible equation given as: FREE DRUG+PROT...
Is Pharmacology Difficult Podcast RESERVOIRS FOR DRUG DISTRIBUTION
August 09, 2020 10:30 - 5 minutes - 3.51 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! In today's episode we will be do a short communication about few more special compartments for drug distribution , say like bones, teeth, fat acting as reservoirs of drug accumulation. Then there are also some transcellular reservoirs like pleural, pericardial , peritoneal sacs, CSF, endolymph, aqueous humor, etc. All are described so as to form a clear picture in your mind frames, all come in a package full of examples which will make you wo...
Is Pharmacology Difficult Podcast DISTRIBUTION OF DRUGS-CELLULAR RESERVOIR
August 08, 2020 10:30 - 4 minutes - 3.17 MBWelcome to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode we will talk about some special compartments of drug distribution which are also known as "Sanctuary Compartments". Heading on this way, our first stop of a classical example is the Cellular reservoir of drugs where I will tell you about a tabular form of learning various tissues of body and their respective particular drug which have higher affinity for these tissues. The interesting fact is that these d...
Is Pharmacology Difficult Podcast PLACENTAL BARRIER TO DRUG DISTRIBUTION
August 07, 2020 15:30 - 6 minutes - 4.82 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets hit half a century with a brand new barrier to drug distribution namely the Placental barrier where we will discuss the passage of drugs across placenta. Firstly, I will tell you about the lipoidal nature of membranes and then accordingly I will list the drugs that pass or are restricted through it. Next, I will give an account of efflux transporters like P-gp, BCRP and MRP3, then I will be describing some...
Is Pharmacology Difficult Podcast LET US MEET AND CELEBRATE ONLINE (50th episode special-1)
August 06, 2020 10:30 - 4 minutes - 3.29 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode we are going to plan an online meeting via youtube live and zoom app. The details are as follows: Youtube channel: https://www.youtube.com/channel/UC-LnUrZKlcBuQaLa2HDQOVg/ Zoom app ID: Meeting ID: 328 754 0008 Passcode: 6jqi32 Topic: Is Pharmacology Difficult Podcast 50 th episode celebration Time: Aug 7, 2020 03:00 PM Mumbai, Kolkata, New Delhi Hope to see you all for the celebration. Till then...
Is Pharmacology Difficult Podcast BARRIERS TO DRUG DISTRIBUTION-3
August 05, 2020 10:30 - 4 minutes - 3.44 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and in today's episode, I will be finishing the topic of Blood Brain Barrier with few modifications, differences, exceptions and whole lot of information and knowledge to share! First of all I will be telling you about the independence of drug exit from CSF from lipid solubility, next a word about Enzymatic barrier , its relation to the prior example of xenobiotics in last sessions, then a modification of blood bran bar...
Is Pharmacology Difficult Podcast BARRIERS TO DRUG DISTRIBUTION- BLOOD BRAIN BARRIER-2
August 04, 2020 14:30 - 5 minutes - 3.66 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode, I certainly have brought a bunch of new fresh roses to share for you all, to arrange in the emptiness of your curious, anxious, knowledge thirsty vase of mind and thoughts, Hope it sounds as fresh as ever and is as beautiful as you expect it to satiate your hearing senses. I begin today's session with yesterday's derivation of a novel concept about as to which drugs can and which cannot pass throu...
Is Pharmacology Difficult Podcast BARRIERS TO DRUG DISTRIBUTION- BLOOD BRAIN BARRIER-1
August 03, 2020 14:30 - 5 minutes - 3.64 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and. in today's episode, we will be knowing about the morphological picture of Blood brain Barrier abbreviated as BBB. I will let you know how its is anatomically in true terms a "dual barrier", the first one being blood brain barrier and second one being the blood - CSF barrier. Next as we continue with our "open sesame" magical words, I will tell you some wonderful facts about efflux transporters located along BBB , t...
Is Pharmacology Difficult Podcast DISTRIBUTION OF DRUGS INTRODUCTION
August 02, 2020 11:30 - 6 minutes - 4.24 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode listen to my pizza making story to mark the beginning of a new topic and it is the Introduction to Distribution of Drugs, and you would be amazed as to how I relate the sprinkling of my mixed herbs on pizza to the drug distribution process! Then I will give the definition of Drug disposition which deals with distribution, metabolism and excretion of drugs. It is an important part of pharmacokinetic...
Is Pharmacology Difficult Podcast PHARMACOLOGICAL FACTORS AFFECTING DRUG ABSORPTION AND BIOAVAILABILITY-3
August 01, 2020 12:30 - 5 minutes - 3.54 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's session let us talk about the last two pharmacological factors affecting Drug Absorption and Bioavailability. The first amongst these is pharmacogenetic factors , I will be repeating and revising the definition and with one old example, I will add on a scoop of new one too , serving you a new flavour of this topic. Secondly we will be conversing about some of miscellaneous factors like route of drug admini...
Is Pharmacology Difficult Podcast PHARMACOLOGICAL FACTORS AFFECTING DRUG ABSORPTION AND BIOAVAILABILITY-2
July 31, 2020 13:30 - 6 minutes - 4.31 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, I am Dr Radhika Vijay, and today we will be talking about few more pharmacological factors affecting drug absorption and bioavailability starting off today's episode with food and various substances, this particular description is full of versatile and exceptional examples to account for! Next turn is of First pass metabolism, hope you remember about this one factor and I need not exaggerate it more except some great examples which i serve in...
Is Pharmacology Difficult Podcast PHARMACOLOGICAL FACTORS AFFECTING DRUG ABSORPTION AND BIOAVAILABILITY-1
July 30, 2020 13:30 - 4 minutes - 3.42 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today's podcast recording was in a mood observing the changing times around all of us, changing season, weather, August is dawning, and Taylor's song august on repeat, Well our topic has changed too!! Its the pharmacological factors affecting drug absorption and bioavailability. To start the discussion, comes the first. factor which is gastrointestinal motility along with gastric emptying. whole description goes hand in hand with examples, so...
Is Pharmacology Difficult Podcast PHARMACEUTICAL FACTORS AFFECTING DRUG ABSORPTION AND BIOAVAILABILITY-2
July 29, 2020 13:30 - 4 minutes - 2.95 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, today continuing with the yesterday's conversation about pharmaceutical factors affecting drug absorption and bioavailability, we will be heading over directly to the next and third factor which is Crystal form of drug, this is followed by water of hydration leading to formation of hydrous forms of drugs! Next talk is about nature of excipients and adjuvants and finally we will be winding our today's talk show with degr...
Is Pharmacology Difficult Podcast PHARMACEUTICAL FACTORS AFFECTING DRUG ABSORPTION AND BIOAVAILABILITY-1
July 28, 2020 15:30 - 7 minutes - 5.24 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today is 28th July and on this new day comes a new podcast session bringing for you a little detail of Pharmaceutical factors affecting bioavailability and absorption of drugs! Firstly I will be creating a pictorial flowchart to form a firm basis of discussion, later I will be icing it with two of first and foremost factors affecting disintegration and dissolution of drugs namely particle size and salt form of drug. These discussions will be ...
Is Pharmacology Difficult Podcast MEASUREMENT OF BIOAVAILABILITY
July 27, 2020 14:30 - 7 minutes - 5.52 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today is a special day.... let us talk about a topic that would be light and crispy, guess what? Something like measurement of Bioavailability. For this task, we will know about different instruments like planimeter, trapezoidal rule, etc. Next step is to know about some important terms like Cmax, Tmax and Area under curve known as AUC. I will be giving you a beautiful picture of the curves, their shapes, their labellings too! Open doors of i...
Is Pharmacology Difficult Podcast PHARMACOKINETICS- DIFFERENT TYPES OF EQUIVALENCES
July 27, 2020 07:30 - 6 minutes - 4.58 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today we will be discussing further the left over different types of equivalences, to break the ice today you will get to know firstly about chemical equivalence , the name gives an indication of chemically equivalent drugs, followed by pharmaceutical equivalence which details into pharmacokinetic bio equivalence. You will be getting a clarity amongst the two by knowing suitable. examples. Then comes therapeutic equivalence which is almost a...
Is Pharmacology Difficult Podcast PHARMACOKINETICS- BIOEQUIVALENCE
July 25, 2020 01:30 - 7 minutes - 4.92 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today I will be talking about a type of very important Equivalence i.e. Bioequivalence. Firstly , we will discuss the whole concept, then we will be beautifying it with suitable examples like very famous brands are compared for their bioequivalence, because little differences make a sea change in bioavailability of these drugs which may prove disastrous. You cannot replace one brand of drug with other during course of treatment without checki...
Is Pharmacology Difficult Podcast PHARMACOKINETICS- BIOAVAILABILTY OF DRUGS
July 23, 2020 00:30 - 7 minutes - 5.41 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today, lets talk talk about something important, yes very important, novel and interesting concept known as Bioavailability of drugs. I will narrate a beautiful story to fulfill your hearing senses and it will be followed by a suitable depiction as we derive a proper definition of this concept called Bioavailibility. This will make the picture of it in your mind crystal clear! I will also touch some other conceptual points like serendipity of...
Is Pharmacology Difficult Podcast PHARMACOKINETICS- METHODS TO DELAY AND FACILITATE ABSORPTION OF DRUGS
July 21, 2020 00:30 - 6 minutes - 4.19 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast!Today we are going to talk about the various methods to delay drug absorption like using appropriate dosage forms, secondly by changing physical characteristics of drug and thirdly by adding a vasoconstrictor or applying a tourniquet. Next in succession, we will also discuss methods to facilitate or hasten absorption, these are first of all by increased diffusion of drugs across membranes and secondly by increasing local blood flow! These meth...
Is Pharmacology Difficult Podcast PHARMACOKINETICS-ABSORPTION VIA DIFFERENT SITES
July 19, 2020 01:30 - 5 minutes - 3.75 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! In today's episode, we will be elaborating the absorption heading as to how it occurs via different sites like firstly via parenteral sites, secondly via lungs and thirdly via topical sites. We will also study some minor processes like passive diffusion, transdermal route, and a very short note on Ophthalmic drugs, so we can easily distinguish all these with their special, unique characteristics and examples. Hope you all like it, till next e...
Is Pharmacology Difficult Podcast BIOTRANSPORTATION OF DRUGS - ENDOCYTOSIS AND FILTERATION
July 14, 2020 20:30 - 6 minutes - 4.26 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast.Today we will definitely put a full stop to our talks about Biotransportation of drugs, Yes! Today we will be covering the tail ends like topics known as Endocytosis which will be including both pinocytosis and phagocytosis, and second one being Filteration which includes its comparison from processes like Active Transport and Facilitated Diffusion. So these are the tail topics which will be marking an end to the large title of Biotransportati...
Is Pharmacology Difficult Podcast BIOTRANSPORTATION OF DRUGS- MEMBRANE TRANSPORTERS
July 13, 2020 00:30 - 4 minutes - 3.36 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, So whats in audio store of today's podcast? Don't worry, I will give an answer to this question. Well, today's topic of the day is Membrane Transporters. Now these are subclassified into two, the first being ATB Binding Cassette i.e. ABC group of transporters, second one is Solute Linked Carrier, i.e SLC transporters. With apt and beautiful examples, the description is up to the mark, simplified and complete enough to enrich your knowledge, t...
Is Pharmacology Difficult Podcast BIOTRANSPORTATION OF DRUGS- PRIMARY AND SECONDARY ACTIVE TRANSPORT
July 11, 2020 01:30 - 11 minutes - 7.86 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! In today's episode we are going to talk about Biotransportation of drugs a step ahead and the title is Active Transport, it is also called as uphill transport and is energy dependent, the two major subdivisions are Primary and Secondary Active Transport. In Primary Active Transport, we are going to talk about ATP Binding Cassettes, Efflux transporters like P-Glycoprotein and on the other hand, Secondary Active Transport will be covering discu...
Is Pharmacology Difficult Podcast CARRIER MEDIATED TRANSPORT- FACILITATED DIFFUSION
July 09, 2020 01:30 - 5 minutes - 3.83 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast, in today's episode, we will be talking about the first type of carrier mediated transport and it is the very famous Facilitated Transport, I will also be discussing the various characteristics of this particular type of transport today! The outline of different characteristics are the graphical details, its property of being capacity limited, energy dependency details and comparison with passive diffusion! Hope you all like the descriptive an...