IS PHARMACOLOGY DIFFICULT®️ Podcast
316 episodes - English - Latest episode: about 1 month ago - ★★★★★ - 2 ratingsWelcome all to "Is Pharmacology Difficult®️ podcast ". This is a Pharmacology podcast !! I am your host, Dr Radhika Vijay, M.B.B.S., M.D. Pharmacology, Sardar Patel Medical College, Bikaner, Rajasthan, India. Pharmacology (medical sciences) is my subject and I think Communicating about it to the masses is very essential. It is of great value and importance to every layman. The episodes here will be in simple English language (with few phrases and add ons of my favourite french language). The basic motto is to create an awareness and impart knowledge of the subject to all interested, concerned, curious and visitors. Pharmacology, the "SCIENCE OF DRUGS", which hold an important place in everyone's life. Here, I will discuss basic tips, strategies and ideas to study medical pharmacology easily and effectively especially for medical, nursing, dental and pharmacy schools and students. Even if you are not from Science stream, this information would be beneficial to you and therefore pay some valuable minutes to this Pharmacology Podcast, and you will not be in loss !! The descriptions will be short pieces of science work lengthy enough to engage you and not to test your patience! So, go ahead, lend your ears to these crispy informative audio files and empower and enrich your sea of knowledge and let me know "IS PHARMACOLOGY DIFFICULT?" For various links, please visit: https://linktr.ee/ispharmacologydifficult. Disclaimer: All the content of the podcast audio is expressed in my own language and learning and understanding viewpoints. References are from the best and reputed subject (Pharmacology) text books, blogs, journals and drug information from reputed and best online sources. I make best efforts to convey the most accurate and updated information of the subject of medical sciences in my special way. I take no money from pharmaceutical industry or drug companies for my podcast. You are most welcome to post your comments, suggestions, etc. through "Contact" page on my website: www.ispharmacologydifficult.com. You all are well known that medical sciences subjects are ever changing, updated and ever evolving, hence no guarantee is taken if the information conveyed in this podcast turns outdated or obsolete with changing and evolving times. This podcast is an expression of my learnings and experiences and in no way representative of any standard authority. Privacy Notice: I collect only email addresses of the subscribers and in no circumstances they will be shared or displayed anywhere on podcast/website/newsletter. Copyright & Distribution: All the contents of "IS PHARMACOLOGY DIFFICULT®️" podcast/website/blog/newsletter are copyrighted. Though all the content related to podcast and various social media handles is free! "BUT" in no way or under no circumstances shall- Any of the podcast content/show notes/blog post/newsletter content/youtube video artwork/podcast artwork and ideas should be used or reproduced or distributed.
Homepage Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
Episodes
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-6
March 03, 2021 13:30 - 10 minutes - 7.06 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today's episode covers Transdermal Therapeutic System (TTS) in details with a few words about Nasal and Inhalational routes of drug administration and specially I laid emphasis on differences of the two. In all these routes as per the tradition, I discussed the important characteristics, features, details covering the mechanism, method, everything followed by pros and cons, essence, ignorance, a...
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-5
February 26, 2021 13:30 - 14 minutes - 9.83 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. After a little break, I am back with more information on injections, today the focus will be on sub cutaneous route of dr...
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-4
February 14, 2021 16:30 - 8 minutes - 5.9 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. After a long gap today's episode is a on going series of our topic injections.to begin with i will start today's talk with Intramuscular Injections where i will be discussing about the site , characters , features, advantages, disadvantages and examples for this route. And next in list is Intradermal Injections. with a few guess games to keep up the spirit, i will call it for the day. Hope you a...
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-3
February 05, 2021 14:30 - 11 minutes - 7.72 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. The celebrated topic of today's episode is the Parenteral Routes of Drug Administration, in this firstly I will define this route, its basic implications. My first choice of injections will be Intra venous, I will talk about its uniqueness, speciality and after explaining its need, etc, I will make you count firstly the advantages of this wonderful route of drug administration actually on your f...
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-2
January 30, 2021 14:30 - 10 minutes - 7.34 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What are the basic good things to know about buccal and rectal routes, what are the pros and cons, all these scintillating points will form head points to form discussion content for today !! As we climb the ladder step by step by routes of drug administration, after oral, next step is sublingual or buccal. Then I will tell you minute difference between the two terms, though they are used interc...
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-1
January 28, 2021 10:30 - 12 minutes - 8.78 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Why different drugs have different routes of administration? What are the advantages and disadvantages of oral route of drug administration? All these questions will be answered in today's episode. Firstly I will break the ice of today's episode with the different properties of drugs and different factors that govern the choosing of different routes of drug administration. I will be actually enl...
Is Pharmacology Difficult Podcast MONOCLONAL ANTIBODIES AS DRUG DELIVERY SYSTEM
January 26, 2021 00:30 - 14 minutes - 9.91 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. How do monoclonal antibodies behave as drug carriers? How are they named so uniquely? In today's episode I will be discussing all this mechanics. Monoclonal antibodies are an important drug delivery system, how the are structured in a very special unique way will be discussed first, then I will be throwing light on different epitopes, the Hybridoma technique to structure these products. It will ...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-10
January 23, 2021 15:30 - 10 minutes - 7.38 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Any guesses about today's episode? Today's conversation covers a very interesting and updated topic , something like Targeted Drug delivery. First and foremost I will define this system of drug delivery, then I will be making you aware of its two types. They are Passive drug targeting and active drug targeting. These are centred around nanoparticles and under these I will talk about magnetolipos...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-9
January 20, 2021 13:30 - 11 minutes - 8.14 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What do you know about Inhalational dosage forms? What are different devices used to deliver these dosage forms? What are different mechanisms and processes? Lets get to know all these... Firstly waiving a green flag to today's conversation, I will comment on Inhalant, Aerosols and finally Spinhalers. Firstly i will tell you which drugs can be given as Inhalations. Then I will be starting the re...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-8
January 17, 2021 11:30 - 7 minutes - 5.21 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you know about Liquid dosage forms for Internal use? How will you differentiate lotions from liniment? All these questions will be answered in today's episode! To break the ice , I will be talking about liniment definition , they are applied locally externally WITH RUBBING, they possess qualities and work through mechanism of counterirritant and rubefacient. I will be talking about these in d...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-7
January 15, 2021 15:30 - 11 minutes - 7.91 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What is the great importance of Liquid Dosage forms in our day to day lives? How would you distinguish between mixtures and emulsions or between spirits and tinctures? All the blurry dust would be cleaned over these information blocks in today's episode. I will be starting today's talk with Aqueous suspensions like mixtures and emulsions. Next I will divert my talks towards Alcoholic suspensions...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-6
January 13, 2021 14:30 - 12 minutes - 8.76 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you know about Liquid dosage forms of Internal use? What is the quick fact file of injection?All the details and much more will be poured all in today's episode. Today's conversation will commence from the discussions about Elixirs and after describing their features in short, I will tell about two important types of ELIXIRS, like syrups, linctus and additional notes on Liquors. Next I will t...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-5
January 10, 2021 12:30 - 12 minutes - 8.63 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What is the thin line of difference between solid and semi solid dosage forms? Thats the topic of today! Amongst the different semi solid dosage forms, first one to talk is ointment, I will tell you the nature, composition and different examples , next I will be talking about Creams, which are in fact a modified version of ointment but what you ought to know is the difference between these two ...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-4
January 08, 2021 12:30 - 7 minutes - 5.16 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Its great to talk to you all today, at the end of first week of brand new shining hopeful year 2021!! What do you expect to be in my pandora's box today? Yes, we are going to halt the chat about solid dosage forms today, for sure. Starting today's great set of talks with the topic of Pills. These are archaich dosage forms, spherical or oval or rounded in shape, quite many times colored.In these...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-3
January 06, 2021 00:30 - 8 minutes - 6.17 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Are we starting with news solid dosage forms today? Yes, we are! Today's highlights of the verbal episode are granules, pellets, lozenges and much more to discover, keep your patience and listening abilities alive for upcoming few minutes. I will start the talk with discussions of granules, these are simply dry powdered particles taken after dissolving them in water, making a solution or suspens...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-2
January 04, 2021 15:30 - 9 minutes - 6.84 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be solving some curious questions regarding content of today's episode, its not loading up information about more dosage forms, but telling you about more new facts about tablets. I will start with the tablet definition , followed by descriptions and essence of Chewable Tablet, their details, their abbreviations! Next comes turn of Tablet for dispersion , nowadays bett...
Is Pharmacology Difficult Podcast DOSAGE FORMS OF DRUGS-1
January 01, 2021 13:30 - 14 minutes - 9.7 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Wish you all a very HAPPY NEW YEAR 2021. We are not off for today, the 1st of January is a working day, blessed day, for me , for you all! In today's episode I will pay a lot of attention to the start of Solid Dosage Forms, where today's talk will commence from Powders, First I will define them, then I will throw light on different varieties of powders like used externally, internally, bulk pow...
Is Pharmacology Difficult Podcast INTRODUCTION TO DOSAGE FORMS | HAPPY NEW YEAR 2021
December 30, 2020 03:30 - 7 minutes - 5.1 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What are the different terms regarding prescribing dictionary? what do you mean by dosage form, excipients, etc. Before we skydive in the winds of variety of dosage forms, lets get acquainted with some important terms used in descriptions of dosage forms of drugs. First and foremost I will talk about the formulation of drug, its the methods or recipe and requires different drug components or ing...
Is Pharmacology Difficult Podcast NAME OF DRUGS-2
December 28, 2020 14:30 - 15 minutes - 10.9 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What are the different rules to name a drug? How does generic name differ from trade name, to know answers of these questions with details about generic names and brand names of drugs, you need to listen to today's episode. The non proprietary names are famously called as generic names.Each drug has a unique INN . A special name stem provides uniqueness to a drug name and associates it with its ...
Is Pharmacology Difficult Podcast NAME OF DRUGS-1
December 27, 2020 01:30 - 9 minutes - 6.31 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. How do you name a drug? Why is Aspirin called as Aspirin? Is it same as Acetylsalicylic acid? What is the basis of all these things? Let us get in to mechanics, traditions, and rules of this name game in today's episode. There are many grounds to classify a drug naming method, especially on basis of molecular structure, etc.Broadly I will classify them in three categories namely Chemical or Scie...
Is Pharmacology Difficult Podcast DRUG CATEGORIES
December 26, 2020 14:30 - 17 minutes - 11.9 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you know the different categories in which the drug can be classified? To dive deep in the point to ponder, Lets get set and start the talk of day by broadly classifying the drugs in two main categories namely Prescription and Non Prescription drugs. Latter are also known as Over the Counter Drugs abbreviated famously as OTC Drugs. After covering all the important details, their basis of bei...
Is Pharmacology Difficult Podcast NATURE OF DRUGS-FEW CONCEPTS
December 25, 2020 14:30 - 13 minutes - 9.48 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. WISHING EVERYONE A VERY MERRY CHRISTMAS!! To start episode, I will be emphasizing the essence of this great holiday and festive season Bonding fosters complete, proper interaction of drugs with receptors. The most important and major bonds to be known are Covalent, Electrostatic and Hydrophobic. Strongest bonds are covalent, many a times irreversible in nature. This concept will be clear with g...
Is Pharmacology Difficult Podcast NATURE & SOURCES OF DRUGS-3
December 25, 2020 13:30 - 9 minutes - 6.34 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. If you want to know about many plant sources left for discussion, what more could be added to the ones already discussed? All these will be known to you all till the full stop. To break the ice, lets have a word about Resins, they are oxidised, polymerised volatile oils, insoluble in water, next I will complete my resin story by fitting some good types of resins along with theur respective examp...
Is Pharmacology Difficult Podcast NATURE & SOURCES OF DRUGS-4
December 25, 2020 13:30 - 10 minutes - 7.54 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What are other drug sources, apart from plant sources, let's dive. deep into this discussion context today, stay akin and get to know all.. Talk takes a positive constructive form, as I initially describe the animal sources of drugs, From olden golden era, different animal organs, different parts of animals have been used medicinally. In present current times, I will be listing a lot many exampl...
Is Pharmacology Difficult Podcast NATURE & SOURCES OF DRUGS-2
December 23, 2020 16:30 - 14 minutes - 10.1 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you want to know about the many non synthetic drug sources, do you wanna know them on your tips? What are the most important ones amongst these? All these questions will be answered in today's session. Initially I will spill some coffee and my thoughts to discuss about non synthetic drug sources. As a common rule, I want to start of this discussion points from the oldest, historically and mo...
Is Pharmacology Difficult Podcast SOURCES OF DRUG INFORMATION-3
December 21, 2020 13:30 - 6 minutes - 4.42 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What are Non Official Drug Information sources? Can they serve as Secondary sources of drug information? All this and much related to this particular topic of discussion will be measured in leaps and bounds in today's episode. If Official drug compendia serves as Primary source, then definitely Non official drug compendia serves as Secondary source of drug information. i will start my talk with ...
Is Pharmacology Difficult Podcast NATURE & SOURCES OF DRUGS-1
December 21, 2020 13:30 - 12 minutes - 8.51 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you have any idea about nature of drugs? Did you ever wonder from where drugs are obtained? all these pearls of information are stringed. in today's episode. I will start my verbal skills with the most groundfooted basic drug origin, its actually a chemical entity, as simple and as complex as you know and you can imagine!first set of classification is in Organic and Inorganic drugs with their...
Is Pharmacology Difficult Podcast SOURCES OF DRUG INFORMATION-2
December 19, 2020 15:30 - 9 minutes - 6.49 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Does your textbook cover all the minute details, I mean all, everything like trade names, drug information, purity, chemical, physical characteristics, etc? Well, if not, in today's episode you will get the knowledge of drug information sources, especially official ones.The collective term used for drug literature is "Drug Compendia". When I say its official, it means that government supervises ...
Is Pharmacology Difficult Podcast BRANCHES/DIVISIONS OF PHARMACOLOGY-3
December 18, 2020 13:30 - 10 minutes - 7.21 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. What is the first thing or picture strikes you when you hear terms familiar something like Pharmacognosy, Pharmacogenetics or Pharmacy, etc. You might have heard these so important and many more like these, I will tell you about these and all familiar important branches of pharmacology today. Talking firstly about Pharmacognosy, its the study of drug sources, it also covers identification of dru...
Is Pharmacology Difficult Podcast SOURCES OF DRUG INFORMATION-1
December 18, 2020 13:30 - 9 minutes - 6.71 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. How Drug therapy evolved? What are the sources of drug information? Responses to these fireshot questions will be given in today's episode. Ancient Mesopotamian, Indian, Chinese, Egyptian records emphasized the disease nature to be something supernatural, a bad omen, Then greek mythology of four humors of body changed this belief and made patient the main focus. Development of science in a rapid...
Is Pharmacology Difficult Podcast BRANCHES/DIVISIONS OF PHARMACOLOGY-2
December 16, 2020 13:30 - 7 minutes - 5.34 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you know What is exactly Chemotherapy? What do you study in Clinical Pharmacology?Why Pharmacoepidemiology is so important? All these questions will be answered to the best of your knowledge and satisfaction in today's episode. Chemotherapy term was initially limited to drug effect upon microorganisms/parasites which are living/multiplying found in living organisms. Drugs possess selective to...
Is Pharmacology Difficult Podcast BRANCHES/DIVISIONS OF PHARMACOLOGY-1
December 16, 2020 12:30 - 9 minutes - 6.88 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Do you know about Poison? Is their study a part of Pharmacology? What could be totally opposite branch? These queries will be answered in today's episode. Let the talk commence.. Chemical actions can take place at two main levels, individual and environment Individual effects occurring at intended organs produce therapeutic effect while effects at unwanted target sites produce toxic or harmful e...
Is Pharmacology Difficult Podcast BASIC DIVISIONS OF PHARMACOLOGY
December 14, 2020 23:30 - 13 minutes - 9.51 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement insi...
Is Pharmacology Difficult Podcast DRUG (Definition & About)
December 14, 2020 12:30 - 7 minutes - 5.21 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode I will be answering questions as to What is a drug? How do you define a drug and whether it is same as medicine? Medicines have always been a close companion of man from birth till death.Purpose of medicine is to provide relief and comfort to man. Drug is derived from french term. Broadly speaking, it is a chemical substance which affects living systems . used to prevent, dia...
Is Pharmacology Difficult Podcast INTRODUCTION/LAUNCH EPISODE
December 12, 2020 14:30 - 10 minutes - 7.06 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, I welcome you all to. History is history, Prehistorically people used crude drugs, substances to cure their ailments, diseases, etc. They superstitiously believed that most of the diseases were due to excess of bile and blood in body. Slowly, eventually, scientific belief and observation took over this old school of thought. In 18th century in British continent, literature evolved as a product o...
Is Pharmacology Difficult Podcast TRAILER EPISODE SEASON 1
December 11, 2020 07:30 - 2 minutes - 1.72 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, MBBS, MD Pharmacology. I belong to Bikaner, Rajasthan, India. This is trailer episode officially of season 1 of my beloved Podcast Is Pharmacology Difficult. The name cracked me while I was Pursuing post graduation in my subject Pharmacology. This podcast is a product of Lockdown. Virtually 2020 has been a blessed year. You will find this as a Solo education podcast, episodes will be on air on ...
Is Pharmacology Difficult Podcast PODCAST NEWS/UPDATE
December 11, 2020 00:30 - 2 minutes - 1.48 MBSend us a Text Message. Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, this is a new big new coming up, an announcement, an update, stay tuned, stay safe, stay enlightened, thank you!! Please leave Review on Apple podcasts! My E-Newsletter sign up at Substack! Connect on Twitter & Instagram! My books on Amazon & Goodreads!
Is Pharmacology Difficult Podcast PHARMACODYNAMICS GPCR REVISION 2
December 07, 2020 13:30 - 5 minutes - 3.76 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be continuing with the revision of the leftover details about GPCR, to start with a little piece of positivity for the Monday and to carry along the whole week. Activated effector through second messengers produces desired effects.First messenger in this case is the Agonist! Stimulation of receptors make responses last several seconds. If agonist is not present, receptor turns to resting sta...
Is Pharmacology Difficult Podcast PHARMACODYNAMICS GPCR REVISION 1
December 06, 2020 12:30 - 4 minutes - 3.41 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be starting with a sort of revision of GPCR, well, truly speaking, there is also added information to the topic, hence revision with addition is the motto, In the starting of episode, I will be introducing a new name for these receptors namely Metabotropic receptors. Then starting with the diagrammatic depiction and sound basis of the mechanism, I will be telling you all that G proteins are co...
Is Pharmacology Difficult Podcast GPCR EFFECTOR PATHWAYS-4
December 05, 2020 13:30 - 7 minutes - 5.34 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be doing the last effector pathway for the functioning of GPCR, how does it actually happen, lets talk about this. The activated G proteins can open or close ion channels specific for Calcium or Potassium channels. This can occur without intervention of any second messenger like cAMP or IP3. This is achieved by hyperpolarisation or depolarisation or changes in intracellular Calcium ion concen...
Is Pharmacology Difficult Podcast GPCR EFFECTOR PATHWAYS-3
December 04, 2020 15:30 - 8 minutes - 5.84 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be verbally putting up my thoughts about more details on my last topic about the second effector pathway of GPCR, namely Phospholipase C:IP3-DAG Pathway. As PKc phosphorylates many intracellular proteins and leads to various physiological responses, it all serves signalling functions. Cytosolic calcium stays low in whole of this event, this is achieved by specific pumps located at plasma memb...
Is Pharmacology Difficult Podcast GPCR EFFECTOR PATHWAYS-2
December 02, 2020 23:30 - 6 minutes - 4.46 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be telling you about second effector pathway of GPCR , it is named as Phospholipase C:IP3 DAG Pathway. As we dive deeper into this talk of the day, Let me start with the basic stepwise mechanism of this pathway, and that all be the content of today's episode. Activation of PLC beta by the activated GTP carrying alpha subunit of Gq leads to hydrolysis of membrane phospholipid PIP2. This process...
Is Pharmacology Difficult Podcast cGMP AS SECOND MESSENGER
December 01, 2020 14:30 - 5 minutes - 3.86 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will limit my talks in a short crispy description about cGMP(cyclic GMP) as a second messenger. cGMP is an intracellular second messenger in a limited number of tissues, like vascular smooth muscle, intestinal mucosal cell and kidney, where it respectively serves to perform actions like smooth muscle relaxation, inhibition of salt and water absorption in mucosal cell, in kidney it mediates natriure...
Is Pharmacology Difficult Podcast GPCR EFFECTOR PATHWAYS-1
November 29, 2020 22:30 - 7 minutes - 5.46 MBWelcome to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will be talking about first of three major Effector pathways through which GPCRs function. It is named as Adenylyl cyclase:cAMP pathway. First step is activation of adenylyl cyclase, it leads to intracellular accumulation of cyclic AMP. After this, cAMP functions through cAMP dependent protein kinase(PKa) . PKa phosphorylates many ion channels, enzymes, etc and leads to lot of manifestations or activi...
Is Pharmacology Difficult Podcast G PROTEIN COUPLED RECEPTORS (GPCRs)
November 26, 2020 22:30 - 15 minutes - 10.8 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode I will telling you about G-Protein Coupled Receptors (GPCRs). They belong to large family of cell membrane receptors. They are found on effectors like enzymes, channels and transporters through GTP activated proteins (G Proteins). Finally they lead to response generation. Diagrammatically, GPCR is a membrane spanning heptahelical molecule, there are 3 extracellular and 3 intracellular loops. Agonist ...
Is Pharmacology Difficult Podcast PHARMACODYNAMICS-ACTION EFFECT SEQUENCE
November 26, 2020 13:30 - 6 minutes - 4.68 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be conversing about Action Effect Sequence of Drugs in Pharmacodynamics. First of all, for your utter kind information, I want to tell you that Drug action and Drug effect are not synonymous. Drug action is the binding of drug to receptor and bringing about a conformational change, while on the other hand, Drug effect is the final biological response produced due to drug action occurring throu...
Is Pharmacology Difficult Podcast PHARMACODYNAMICS- RECEPTOR SUBTYPES
November 25, 2020 23:30 - 14 minutes - 9.94 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode I will be covering details about receptors more, specifically RECEPTOR SUBTYPES. Starting with examples for receptors of acetylcholine, namely Muscarinic (M), Nicotinic (N) receptors. These findings were confirmed with help of blockers. Ahlquist divided adrenergic receptors into alpha and beta based on different potencies of agonists. These all receptors are further subdivided in many subdivisions. Th...
Is Pharmacology Difficult Podcast NATURE OF RECEPTORS
November 23, 2020 22:30 - 10 minutes - 7.01 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will go ahead by leaps and bounds to describe an introductory remark about the nature of receptors.Receptors are regulatory macromolecules, mostly proteins, some nucleic acids are also receptors. Numerous receptors amino acid sequence has been worked out and configuration plays an important role in sub classifying receptors. Basically, protein structures float in lipid membranes and there is intera...
Is Pharmacology Difficult Podcast TWO STATE RECEPTOR MODEL-2
November 22, 2020 12:30 - 9 minutes - 6.59 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode I will be adding value and new examples with information and definitions to the last episode, few concepts will definitely be revised and refreshed!!After all the breaks, festival omissions, in last topic's continuation, I will be telling that molecular forces alter configuration, its the dual receptor model, Ra and Ri, they might relate to open and closed state of ion channel, active and inactive rec...
Is Pharmacology Difficult Podcast TWO STATE RECEPTOR MODEL
November 18, 2020 22:30 - 8 minutes - 5.97 MBWelcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay. In today's episode, I will talk about the Two state receptor model, on the basis of which we can alternatively describe, Agonist, Competitive antagonist , Partial agonist and Inverse agonist. The receptor is believed to exist in two interchangeable states, Ra(active state ), Ri(inactive state). Both stay in equilibrium. Ri state is favored at equilibrium. Agonist(A) binds preferentially to Ra, equilibrium shifts, a cer...