AMiNDR: A Month in Neurodegenerative Disease Research
350 episodes - English - Latest episode: 20 days ago -This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. For a given month, we sort the abstracts of the latest primary research articles on Alzheimer's disease into separate categories. We then summarize them for you to enjoy on the bus, on your jog, or in the lab. We hope you find our podcast useful and accessible.
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Episodes
193 - Clinical Markers of Alzheimer's Disease: June 2021
August 18, 2021 06:39 - 29 minutes - 27.2 MBIn this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode: Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspe...
192 - Risk Factors for Alzheimer's Disease: June 2021
August 17, 2021 03:10 - 48 minutes - 44.4 MBNaila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy! Sections in this episode: Prevalence, incidence, multiple factors (2:08) Cardiovascular (20:33) Other health conditions (25:30)...
191 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: June 2021
August 13, 2021 21:00 - 22 minutes - 20.3 MBHere, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it. Sections in this episode: Amyloid-beta based detection (1:30) Tau based dete...
190 - Brain Connectivity Changes in Alzheimer's Disease: June 2021
August 13, 2021 01:00 - 20 minutes - 18.4 MBInterested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new! Sections in this episode: fMRI (01:32) Machine Learning (12:10) Other (14:36) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, ...
189 - Vascular Contributions to Alzheimer's Disease & Treatments Targeting the Vasculature: June 2021
August 12, 2021 04:56 - 21 minutes - 20 MBWith a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome! Sec...
188 - APP processing & Amyloid-beta aggregation in Alzheimer's Disease: June 2021
August 11, 2021 03:29 - 30 minutes - 27.6 MBOnly 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity. Sections in this episode: APP Processing & Secretases (3.15) Characterizing Aggregate Content (7.00) Amylo...
187 - Prevention & Intervention Strategies for Alzheimer's Disease: June 2021
August 10, 2021 04:43 - 27 minutes - 25.3 MBIn this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques. Sections in this episode: Exercise (1:37) Multidomain / Other (7:05) Neuromodulatory Techniques (15:20) --------------------------...
186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021
August 06, 2021 23:00 - 24 minutes - 22 MBJoin our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) ------------------------------------...
185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021
August 05, 2021 23:00 - 18 minutes - 17.2 MBIn this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://dri...
184 - Synaptic Transmission in Alzheimer's Disease: June 2021
August 05, 2021 03:51 - 33 minutes - 30.3 MBCurious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses! Sections in this episode: Synapse Function and Plasticity...
183 - Changes to Gene Expression in Alzheimer's Disease: June 2021
August 04, 2021 01:35 - 18 minutes - 16.7 MBWe know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expressi...
182 - Cognitive & Behavioural Changes in Alzheimer's Disease: June 2021
August 02, 2021 23:31 - 39 minutes - 36.2 MBEllen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode: Cognition & Attention (3:32) Memory (9:59) Speech & Communic...
181 - Clinical Markers of Alzheimer's Disease Part 2: May 2021
July 15, 2021 04:24 - 18 minutes - 17 MBFrom standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03) -------------------------------------------------------------- You c...
180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021
July 14, 2021 05:40 - 33 minutes - 30.7 MBIn this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08) Language and cultural ad...
179 - Treatments targeting the Immune System & Glial Cells in Alzheimer's Disease: May 2021
July 13, 2021 03:35 - 35 minutes - 32.5 MBAbdullah takes you through papers from May 2021 on treatments to target the immune system and glial cells to treat Alzheimer's Disease. This includes things like coconut looking funguses and olive oil. These are just a few of the treatments being covered in this episode, tune in to find out more! Sections in this episode: Inflammasomes (3:31) Effects on Neuroinflammation (9:17) Miscellaneous Papers (24:20) -------------------------------------------------------------- To a...
178 - Amyloid-Beta Pathology in Alzheimer's Disease: May 2021
July 10, 2021 03:00 - 38 minutes - 35.5 MBIn the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy! Sections in this episode: ...
177 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: May 2021
July 09, 2021 04:15 - 30 minutes - 27.7 MBThis episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis. Sections in this episode: Targeting cholinesterases and oxidative stress (1.56) Targeting glutamate and excitotoxicity (22.33) Targeting Adrenergic Receptor (26.58) ...
176 - Familial Mutations, New Variants & Other Genetic Insights in Alzheimer's Disease: May 2021
July 07, 2021 22:00 - 32 minutes - 29.7 MBWow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics. Sections in this episode: Methods for Gene and Pathway Discovery (1:46) GWAS, Transcriptome, Exome Sequencing (5:47) Miscellaneous (12:55) Familial AD (17:11) -------------------------------------------------------------- You can find the numbered bibliography ...
175 - Role of the Immune System & Glial Cells in Alzheimer's Disease: May 2021
July 06, 2021 21:00 - 33 minutes - 30.5 MBIn this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Microglia (02:07) Astrocytes (10:42) TREM2 (13:34) Metabolism (18:08) Periphery (24:53) --------------------------...
174 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: May 2021
July 06, 2021 06:10 - 33 minutes - 31 MBIn part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode: Depression (2:27) Anxiety (5:26) Stress & PTSD (9:55) Agitation (13:30) Emotional Reactivity (17...
173 - APP Processing & Amyloid-Beta Aggregation in Alzheimer's Disease: May 2021
July 03, 2021 05:15 - 39 minutes - 36.5 MBHello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus on plaques, so stay tuned if you need an upd...
172 - Detection of Amyloid, Tau, and other PET Targets in Alzheimer's Disease: May 2021
July 02, 2021 03:15 - 22 minutes - 20.4 MBIn this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections in this episode: Tau Based Detection (1:48) A-beta Base...
171 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: May 2021
July 01, 2021 05:37 - 24 minutes - 22.8 MBIn part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode: Cognition in AD patients (4:09) Cognition in animal models (9:38) Motor impairments (19:00) ------------------------------------------------------------- PLEASE ...
170 - Hemodynamics, Metabolic Changes & EEG in Alzheimer's Disease: May 2021
June 30, 2021 06:07 - 24 minutes - 22.4 MBFrom working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ---------------------------------------------...
169 - Treatments targeting Neuroprotection and Synaptic Activity in Alzheimer's Disease: May 2021
June 29, 2021 01:00 - 35 minutes - 32.6 MBAnusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using Pre-existing Synthetic ...
168 - Prevention and Intervention Strategies for Alzheimer's Disease: May 2021
June 25, 2021 22:32 - 46 minutes - 42.4 MBIn this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD. Sections in this episode: Diet (2:52) Exercise (9:01) Multidomain Interventions...
167 - Vascular Contributions to Alzheimer Disease and Treatments Targeting the Vasculature: May 2021
June 25, 2021 01:51 - 34 minutes - 31.8 MBElyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode: Overlap Between ...
166 - Imaging of Connectivity Changes in Alzheimer's Disease: May 2021
June 24, 2021 03:08 - 21 minutes - 19.6 MBCome join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more! Sections in this episode: fMRI (2:00) MRI (10:51) Other (15:43) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GI...
165 - Understanding ApoE in Alzheimer's Disease: May 2021
June 23, 2021 07:16 - 25 minutes - 23 MBIn this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode: Genetic Risk Factors (2:12) Biomarkers in Alzheimer's Disease (7:15) Risk Factors of Alzheimer's Disease (1...
164 - Synaptic Transmission in Alzheimer's Disease: May 2021
June 22, 2021 07:57 - 45 minutes - 41.6 MBEllen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode: Neurogenesis (5:11) Synaptic Plasticity (8:46) Neurotransmitter Signaling (18:26) Excitation/Inhibition Balance (28.07) Growth Factors (32:16) ...
163 - Treatments targeting Oxidative Stress & Metabolism in Alzheimer's disease: March 2021
May 29, 2021 04:51 - 43 minutes - 40.1 MBIf you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in March 2021. She covers 17 abstracts that harness the interconnectedness between mechanisms involve...
162 - Familial Mutations, New Variants, and More Genetic Insights in Alzheimer's Disease: March 2021
May 28, 2021 02:00 - 16 minutes - 14.8 MBIn this short episode, Joseph goes over 9 studies published in March 2021 that include GWAS’s, ethnicity-specific genetic studies and research on familial AD genetics. Tune in to learn more! Sections in this episode: GWAS and other population level studies (2:22) Ethnicity Specific Studies (7:44) Familial AD Genetics (11:28) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it wi...
161 - Amyloid-Beta Processing & Aggregation in Alzheimer's Disease: March 2021
May 26, 2021 22:00 - 51 minutes - 47.3 MBJacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end! Sections in this episode: Amyloid-beta processing (2:02) Amyloid-beta detection (13:00) Amyloid-beta membrane interactions (18:35) Proteins controlling aggregation, prion protein & prion-li...
160 - Treatments targeting the Immune System, Glia, Autophagy & Proteostasis in Alzheimer's Disease: March 2021
May 26, 2021 03:00 - 33 minutes - 30.3 MBIn this episode, you'll hear about the latest research on targeting neuroinflammation, glial cells, autophagy and proteoastis to treat Alzheimer's Disease. This includes some studies that want to increase neuroinflammation and some that want to decrease it! How can they both work? You'll have to listen to find out. Sections in this episode: Treatments targeting Neuroinflammation and Neurodegeneration (3:31) Proteostasis and Autophagy (24:58) -----------------------------------------...
159 - Clinical Markers of Alzheimer's Disease Part 2: March 2021
May 25, 2021 00:00 - 25 minutes - 23.7 MBIn Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more! Sections in this episode: Multiple Symptoms (2:47) Neuropsychiatric Symptoms (6:51) Sensory Symptoms (11:05) Motor Symptoms (18:23) -------------------------------------------------------------- To access the folder...
158 - Clinical Markers of Alzheimer's Disease Part 1: March 2021
May 24, 2021 00:30 - 39 minutes - 35.9 MBIn part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detection even better! Sections in this episode: Multi-Domain Cognitive Testing (3:16) Na...
157 - Changes to Gene Expression in Alzheimer's Disease: March 2021
May 22, 2021 00:00 - 34 minutes - 31.6 MBTranscriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD models, etc. We also touch upon the up-and-coming field of multiomics, so tune in to hear more! ...
156 - Detection of Amyloid, Tau and New PET Targets in Alzheimer's Disease: March 2021
May 21, 2021 04:54 - 24 minutes - 22.2 MBIn today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets. Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models. Sections in this episode: Amyloid/Tau PET Targets Tau pathology (1:08) PET image processing and data analysis (6:45) Animal models (11:53) Miscellaneous (14:47) Other PET ...
155 - Prevention & Intervention Strategies for Alzheimer's Disease: March 2021
May 20, 2021 04:21 - 44 minutes - 40.7 MBWe've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this l...
154 - Role of the Immune System & Glial Cells in Alzheimer's Disease: March 2021
May 18, 2021 23:30 - 32 minutes - 29.8 MBIn this episode, Courtney takes you through the papers from March of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, systemic inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Systemic Inflammation (2.02) Neuroinflammation in Humans (6.27) Astrocytes in AD (9.41) Microglia in AD (13.24) Neuroinflammation in...
153 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: March 2021
May 17, 2021 22:00 - 42 minutes - 38.8 MBTune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much more! You're sure to learn a lot in this jam-packed episode. Sections in this episode: Cha...
152 - Vascular Contributions to Alzheimer's Disease & Treatments targeting the Vasculature: March 2021
May 17, 2021 04:05 - 28 minutes - 26.3 MBTired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping out cerebrovascular damage across the AD continuum. This is a shorter episode, with only 13 pape...
151 - Brain Metabolic, Hemodynamic, and Connectivity Changes in Alzheimer's Disease: March 2021
May 15, 2021 03:41 - 20 minutes - 18.6 MBIn this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun! Sections in this episode: PET (1:05) MRI (5:27) EEG (10:24) Other (13:01) ----------------------------------------------------...
150 - Mechanisms of Synaptic Transmission in Alzheimer's Disease: March 2021
May 14, 2021 03:00 - 24 minutes - 22.4 MBFollow along with Glory in this episode, as we dive into papers that try to uncover the link between changes in synaptic transmission and plasticity with cognitive decline and memory loss in Alzheimer's disease. We'll discuss the most recent research on molecular and structural mechanisms at the synapse that underlie Alzheimer's pathology! Tune in for topics such as presynaptic SNAREs, postsynaptic ion channels, neurotransmitter signalling and more! Sections in this episode: Synapse Stru...
149 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 2: March 2021
May 12, 2021 22:00 - 37 minutes - 34.6 MBIn part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment. Sections in this episode: Comorbidities in general (frailty, dermatitis, cancer, head injury,...) (2.00) Focus on sleep apnea (18.30) Foc...
148 - Epidemiology of Risk Factors for Alzheimer's Disease: March 2021
May 11, 2021 22:00 - 29 minutes - 26.6 MBIn part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographie...
148 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 1: March 2021
May 11, 2021 22:00 - 29 minutes - 26.6 MBIn part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographie...
147 - Treatments targeting neuroprotection, synaptic activity & neurotransmitter release in Alzheimer's Disease: March 2021
May 10, 2021 22:00 - 43 minutes - 40 MBAnusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you! Sections in this episode: Targeting neuro/synaptic protection with peptides (2.29) Using existing drugs (9.42) Disease mechanisms (17.26) ...
146 - Understanding APOE in Alzheimer's Disease: March 2021
May 10, 2021 04:44 - 24 minutes - 22 MBHooray! The first episode of our March 2021 series is here! In this episode, Courtney takes you through the papers from March 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on ApoE in cognition, ApoE on biomarkers and pathology, and mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode: Impact of ApoE on Cognition (2:06) Biomarkers in AD (8:43) Metabolism (14:37) Mole...
145 - New Genetic Variants & Insights in Alzheimer's Disease: February 2021
April 20, 2021 22:00 - 33 minutes - 30.9 MBTwin studies, GWAS, TWAS, EWAS and more - In this episode, Joseph takes you through 20 papers published in February 2021 that explore novel genes or variants associated with Alzheimer’s Disease, studied associations of novel pathways to AD or link molecular pathways of other diseases to AD. Sections in this episode: Comorbidities and other conditions (1:28) Identification and Validation of Risk Genes and Loci (9:10) Changes in the Brain (21:02) New Tools Development (26:01) ...