AMiNDR: A Month in Neurodegenerative Disease Research
350 episodes - English - Latest episode: 20 days ago -This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. For a given month, we sort the abstracts of the latest primary research articles on Alzheimer's disease into separate categories. We then summarize them for you to enjoy on the bus, on your jog, or in the lab. We hope you find our podcast useful and accessible.
Homepage Google Podcasts Overcast Castro Pocket Casts RSS feed
Episodes
291 - Vascular Contributions to Alzheimer's Disease: May 2022
August 01, 2022 19:00 - 20 minutes - 19 MBElyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53) Preclinical Studies/Methology (12:41) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the lin...
290 - Treatments Targeting Neuroprotection in Alzheimer's Disease: May 2022
July 29, 2022 19:00 - 22 minutes - 20.9 MBAnusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions! Drug Discovery/Development (1:52) Targeting Neuronal Functions (9:19) Targeting Neuroprotection (14:2...
289 - Cognitive and Behavioural Changes in Alzheimer's Disease: May 2022
July 27, 2022 19:00 - 25 minutes - 23.1 MBIn this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more! Sensory Processing (1:45) Mouse Models (5:44) Clinical Treatments (8:34) Sleep (12:59) Other (17:29) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click he...
288 - New Variants and Genetic Insights Part 1: May 2022
July 25, 2022 19:00 - 22 minutes - 21 MBIn this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies! GWAS and Polygenic Risk Scores (2:20) Cognitive & Social Genetic Studies (8:42) Tool development (11:46) Gene Discovery (14:41) Studies on Amyloid and Tau (16:09) -------------------------------------------------------------- To find the numbered bib...
287 - Cognitive Assessment in Alzheimer's Disease: May 2022
July 22, 2022 19:00 - 36 minutes - 33.4 MBWelcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in general. Learning and Memory (7:17) Perceptual and Motor Skills (20:23) Language (22:33) Acti...
286 - Synaptic Transmission in Alzheimer's Disease: May 2022
July 20, 2022 19:00 - 16 minutes - 14.9 MBAMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic! Sections in this episode: Calcium Homeostasis (2:54) Synaptic Function in Animal Models (5...
285 - Prevention and Intervention Strategies for Alzheimer's Disease: March 2022
June 10, 2022 22:00 - 44 minutes - 40.6 MBIn the final episode of the March 2022 series, Naila takes you through 18 papers on non-pharmacological strategies for preventing or treating Alzheimer's disease. You'll hear the latest from animal studies on exercise, learn about the potential benefits of brown rice, pet ownership and yoga, and be guided through a number of techniques that are being used to modulate brain activity with the hopes of improving cognition or slowing disease progression. Enjoy! Note: We will be skipping the m...
284 - Cognitive Assessment in Alzheimer's Disease Part 2: March 2022
June 06, 2022 19:00 - 36 minutes - 33.3 MBWelcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for prognostic purposes. Yes, you read this correctly, all this goodness packed in 1 episode! Sections...
283 - Cognitive Assessment in Alzheimer's Disease Part 1: March 2022
May 28, 2022 05:23 - 31 minutes - 29.1 MBThis is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect for you if you are researching cognition, or are interested in Neurology or Geriatrics in genera...
282 - Treatments Targeting Neuroprotection in Alzheimer's Disease: March 2022
May 26, 2022 04:31 - 22 minutes - 20.6 MBAnother 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too? Sections in this episode: Stem Cell-Based Therapy (3.01) Testing compounds in A-Beta AD Models (4.52) Testing compounds in APP/PS1 AD Model...
281 - Synaptic Transmission in Alzheimer's Disease: March 2022
May 24, 2022 03:35 - 18 minutes - 17.1 MBEase in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too! Sections in this episode: Synaptic Connectivity Changes (1.44) APP/Tau contribution to Synaptic Dysfunction (7.47) -------------------------------------------------------------- To find the numbered ...
280 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2022
April 30, 2022 02:05 - 17 minutes - 15.9 MBIn February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials. Sections in this episode: Drug Discovery (2.01) Drug Development (4.59) Clinical Trials (11.58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, clic...
279 - Treatments Targeting the Immune System in Alzheimer's Disease: February 2022
April 28, 2022 04:28 - 29 minutes - 27 MBFebruary 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms. Sections in this episode: Microbiome (1:55) NF-kappaB signaling pathway (6:12) Sexual dimorphism (11:34) Naturally-occurring & pharmaceutical treatments (15:37) -------------------------------------------------------------- To ...
278 - Risk Factors for Alzheimer's Disease Part 1: February 2022
April 26, 2022 00:13 - 42 minutes - 39.2 MBIn today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com! Sections in this episode: Epidemiological Studies (1:56) Racial/Ethnic Disparities (11:50) Social D...
277 - Cognitive Assessment in Alzheimer's Disease Part 2: February 2022
April 23, 2022 02:00 - 34 minutes - 31.6 MBWelcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cognitive decline for the diagnosis of Alzheimer’s disease, Mild Cognitive Impairment, or dementia in general. Sections in this episode: Consider...
276 - Cognitive Assessment in Alzheimer's Disease Part 1: February 2022
April 22, 2022 23:35 - 31 minutes - 28.5 MBIf you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hear about the abstracts dedicated to specific cognitive domains in the clinical assessment of cognitive impairment, published in February 2022! S...
275 - Prevention and Intervention Strategies for Alzheimer's Disease: February 2022
April 20, 2022 21:00 - 43 minutes - 39.6 MBThis month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics! Sections in this episode: Cognitive and Multidomain Interventions (1:35) Diet (7:42) Exerc...
274 - Vascular Contributions to Alzheimer's Disease: February 2022
April 18, 2022 22:00 - 37 minutes - 34.6 MBEver wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode covering papers published on PubMed in February 2022. Sections in this episode: Clinical In...
273 - Risk Factors for Alzheimer's Disease Part 2: January 2022
April 05, 2022 00:33 - 28 minutes - 26.3 MBIn Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology. Sections in this episode: Cardiovascular Factors (2:35) BMI (12:25) Diabetes and Related Conditions (14:49) ----------------------------------------------...
272 - Risk Factors for Alzheimer's Disease Part 1: January 2022
March 30, 2022 22:00 - 28 minutes - 26 MBIn Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for Part 2 coming soon! Sections in this episode: Sociodemographic and Lifestyle Factors (2:11)...
271 - Vascular Contributions to Alzheimer's Disease: January 2022
March 29, 2022 07:39 - 40 minutes - 37.4 MBWith her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022! Sections in this episode: Clinical Insights - Vascular Risk Factors (3:46) Blood-Brain Barrier Dysfunction (9:41) Amyloid Deposition and Clearance (30:31) Treatment Avenues (35:22) ----------------...
270 - Treatments Targeting Neuroprotection in Alzheimer's Disease: January 2022
March 26, 2022 03:34 - 26 minutes - 24.6 MBPssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models. Sections in this episode: Treatments using stem cells (2.18) Protecting against A-beta induced toxicity (4.59) Protecting against glutamate-induced cytotoxicity (9.20) Treatments tested in tra...
269 - Structural Changes in the Brain in Alzheimer's Disease: January 2022
March 24, 2022 18:41 - 28 minutes - 26.1 MBWhat information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD. Sections in this episode: Gray and white matter changes (2.25) Correlations of structural changes with biomarkers (9.28) Methods for early detection (15.27) Software packages for brain volumetry (19.03) Radiomic (...
268 - Prevention and Intervention Strategies for Alzheimer's Disease: January 2022
March 22, 2022 09:44 - 39 minutes - 36.1 MBToday's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, and more! Sections in this episode: Interventions Targeting Cognition (1.50) Multidomain...
267 - Synaptic Transmission in Alzheimer's Disease: January 2022
March 14, 2022 21:00 - 21 minutes - 19.6 MBWe start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End neuro-transmission ;) Sections in this episode: Changes to GABAergic transmission (2.41) Changes to calcium flu...
266 - Risk Factors for Alzheimer's Disease: December 2021
March 08, 2022 00:00 - 36 minutes - 33.3 MBDiscover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD. Sections in this episode: Prevalence and Socioeconomic Factors (1:45) Nutrition (13:11) Health-Related Factors (18:49) -------------------------------------------------------------- To find the numbered bibliography with all the pap...
265 - Treatments Targeting Neuroprotection in Alzheimer's Disease: December 2021
March 02, 2022 22:00 - 19 minutes - 18.2 MBIn this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode! Sections in this episode: Testing Naturally-Derived Compounds (3.35) Testing Pre-Existing Drugs (10.54) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episo...
264 - Tau Protein Pathology in Alzheimer's Disease: December 2021
February 28, 2022 22:00 - 21 minutes - 20 MBTickled by tau? Preoccupied with post-translational modifications? Join Kate as she covers the latest papers published in December 2021 on tau protein pathology and targeting tau as a therapeutic strategy in Alzheimer's disease. Sections in this episode: Tau Aggregation & Post-Translational Modifications (3:19) Generalized Tau Pathology & Tau Seeding (7:29) Treatments Targeting Tau in AD (13:50) -------------------------------------------------------------- To find the number...
263 - Vascular Contributions to Alzheimer's Disease: December 2021
February 24, 2022 00:20 - 24 minutes - 22.5 MBTired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter. Sections in this episode: Insights from Clinical Studies (4:10) Insights from Animal Models (14:47) ------------------------------------------...
262 - Prevention and Intervention Strategies for Alzheimer's Disease: December 2021
February 22, 2022 06:18 - 27 minutes - 24.9 MBIn today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy! Sections in this episode: Cognition and Sleep (1.34) Exercise (6.28) Neuromodulatory Techniques (12.16) ---------------...
261 - Clinical Assessment in Alzheimer's Disease Part 2: December 2021
February 19, 2022 21:12 - 23 minutes - 21.7 MBThis episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientists and clinicians are getting us closer to these goals! Sections in this episode: New or Upd...
260 - Clinical Assessment in Alzheimer's Disease Part 1: December 2021
February 18, 2022 17:00 - 30 minutes - 28.3 MBCan smell, gaze, blinking rate, or handwriting offer a window into what happens inside the Alzheimer’s disease brain? Are there parameters we can add to our batteries for assessing cognitive decline in a clinical setting? Missed opportunities in cognitive assessment? Maybe. This episode is dedicated to all kinds of variables that can help orient ourselves on the Alzheimer’s disease continuum, and perhaps predict the progression from MCI to AD. Sections in this episode: Non-Cognitive Va...
259 - Changes to Synaptic Transmission in Alzheimer's Disease: December 2021
February 17, 2022 00:00 - 20 minutes - 19 MBCould changes to synaptic transmission underlie Alzheimer's disease pathology? Anusha has 8 papers to help you answer that question. These papers assess changes in humans, human models, and animal models and were all published in December of 2021. Sections in this episode: Changes in Neuronal Activity in Humans and Human Models (2.50) Changes in Neurogenesis in APP/PS1 Transgenic AD Mice (10.08) Changes in Neuronal Activity in APP/PS1 Transgenic AD Mice (13.42) ----------------...
258 - Cognitive & Behavioural Changes in Alzheimer's Disease: December 2021
February 15, 2022 06:30 - 35 minutes - 32.5 MBTo kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this episode! Sections in this episode: Sensory Function & Processing (3:38) Emotional Processi...
257 - Risk Factors for Alzheimer's Disease: November 2021
February 10, 2022 00:00 - 39 minutes - 36 MBNaila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy! Sections in this episode: Epidemiological and Environmental (1.44) Vaccine/Medication Use (15.10) Psychomotor (22.48) Metabolic Comorbidities (26.18) Other Comorbidities (31.11) -----------------------------------------------------------...
256 - Autophagy and Proteostasis in Alzheimer's Disease: November 2021
February 08, 2022 03:34 - 28 minutes - 26.3 MBTired of only hearing about tau or a-beta when it comes to AD research? Take a peek behind the scenes with Kate to explore the latest on the proteostasis and autophagy pathways that work to safeguard our cells in 13 papers from November 2021. Sections in this episode: Autophagy & Proteostasis Pathology (4:17) Targeting Proteostasis/Autophagy Machinery (22:21) -------------------------------------------------------------- To find the numbered bibliography with all the papers cove...
255 - Treatments Targeting Neuroprotection and Neurotransmission in Alzheimer's Disease: November 2021
February 04, 2022 21:00 - 32 minutes - 29.7 MB17 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in November of 2021. Sections in this episode: Targeting synaptic dysfunction (2.34) Targeting M...
254 - Tau Protein Pathology in Alzheimer's Disease: November 2021
February 03, 2022 00:00 - 30 minutes - 28 MBJoin Kate for a comprehensive summary of everything tau from papers published in November 2021. We'll talk post-translational modifications, prion-like seeding pathology, molecular modeling, and even touch on a potential AD therapies targeting this fascinating little microtubule helper. Enjoy! :) Sections in this episode: Tau Aggregation and Post-Translational Modifications (03:03) Tau Seeding and General Tau Pathology (12:49) Novel Therapeutics (22:58) -----------------------...
253 - Vascular Contributions to Alzheimer's Disease: November 2021
January 31, 2022 17:00 - 23 minutes - 21.2 MBInterested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models! Sections in this episode: Endothelial Cell Biology & Amyloid Clearance (4:40) Insights from Animal Mode...
252 - Clinical Assessment of Alzheimer's Disease: November 2021
January 29, 2022 02:00 - 37 minutes - 34.5 MBWelcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive parameters ...
251 - Prevention & Interventions for Alzheimer's Disease: November 2021
January 27, 2022 04:27 - 25 minutes - 23.2 MBIn today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating! Sections in this episode: Modifiable Risk Factors (2:02) Neuromodulatory Techniques (8:55) ---------------------...
250 - Changes to Synaptic Transmission in Alzheimer's Disease: November 2021
January 25, 2022 03:00 - 17 minutes - 16.3 MBYou have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey of curiosity. Sections in this episode: Synaptic Changes in AD Mouse Models (2....
249 - Cognitive & Behavioural Changes in Alzheimer's Disease: November 2021
January 21, 2022 17:00 - 27 minutes - 25 MBTo kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research all about cognition and behavioural symptoms in AD. Sections in this episode: Mild Behaviou...
SPECIAL: Lessons from Grad School with Neuropsyched Magazine
January 18, 2022 01:48 - 1 hour - 76 MBIn this special episode of AMiNDR, where we sit down with Jenn Kim and Lucy Aceves, two of the creators of the graduate student-run Neuropsyched Magazine! We talk all things graduate school and academia -- from useful tips for choosing a PI, our experiences of grad school during the pandemic, financial barriers we have faced, and establishing boundaries. We also tell you about Neuropsyched magazine, and what working in science communication means to all of us! This conversation was a blast ...
247 - Risk Factors for Alzheimer's Disease Part 2: October 2021
January 14, 2022 17:00 - 27 minutes - 25.1 MBNaila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers! Sections in this episode: Lifestyle factors (1:39) Nutrition (7:08) Physical and Psychiatric Comorbities (13:30) ------------------------------------------------------...
246 - Risk Factors for Alzheimer's Disease Part 1: October 2021
January 12, 2022 17:00 - 26 minutes - 24.4 MBIn Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2! Sections in this episode: Prevalence and Demographics (1:33) Education (7:51) Socioeconomic status and occupation (14:13) Other (23:38) ------------------------------------------...
245 - Synaptic Transmission in Alzheimer's Disease: October 2021
January 10, 2022 20:00 - 23 minutes - 21.5 MBThinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode. Sections in this episode: Synaptic dysfunction in rodent AD models (2.58) Synaptic dysfunction in other AD models & human studies (16.41) -------------------------------------------------------------- You can find the numbered bibliography for this epis...
244 - Vascular Contributions to Alzheimer's Disease: October 2021
January 07, 2022 22:00 - 23 minutes - 21.5 MBElyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia. Sections in this episode: White Matter Hyperintensities (4:13) Blood-Brain Barrier (13:57) Cerebral Amyloid Angiopa...
243 - Autophagy & Proteostasis in Alzheimer's Disease: October 2021
January 06, 2022 03:26 - 34 minutes - 31.4 MBNew year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy! Sections in this episode: Autophagy & Proteostasis Pathology (4:42) Targeting Proteostasis/Autophagy Mach...
242 - New Variants & Genetic Insights Part 2: October 2021
January 04, 2022 02:00 - 27 minutes - 25.3 MBWelcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in! Sections in this episode: Transcriptomics/Gene Expression Changes (2:33) Genetic Variants (6:16) Genetic Risk (13:14) MicroRNA (20:10) Other Topics (22:52) ----------------------------------...