X:BOT primary outcomes

We discuss the X:BOT primary outcomes paper in this episode of the podcast. Use the link above or the citation below to find it. Take a look at the figures!

JD Lee et al.  Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicenter, open-label, randomized controlled trial. Lancet 2018. 391:309-318.

 

X:BOT rationale and design paper

In this fascinating and thoughtful paper, the X:BOT authors discuss the study design choices they considered and how they selected various aspects of the trial design. A great read for those with interest in OUD treatment or clinical trials design.

X:BOT cost effectiveness analysis

This planned analysis of the X:BOT data provides an additional lens for determining which medication is the best option.

A great buprenorphine review

Thorough  but brief review on the  use of buprenorphine.