Is Prazosin Effective for PTSD? Depends on the Inclusion Criteria
Yeah, No Journal Club
English - April 30, 2021 05:00 - 22 minutes - 20.8 MB - ★★★★★ - 4 ratingsMental Health Health & Fitness substance abuse therapy psychiatry mental health treatment substance abuse treatment Homepage Download Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
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The article we discuss is MA Raskind et al. Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans. New England Journal of Medicine 2018; 378(6):507-517
For an example of an earlier study that DID find benefit of prazosin for PTSD, check out Raskind, MA et al. A Trial of Prazosin for Combat Trauma PTSD with Nightmares in Active-Duty Soldiers Returned from Iraq and Afghanistan. Am J Psychiatry 2013; 170: 1003-1010.
Recent meta-analyses of the efficacy of prazosin for PTSD can be found here and here.
A brief review on the ethical principles of equipoise in research.