Intranasal Esketamine and the Placebo Response
Yeah, No Journal Club
English - November 30, 2020 13:43 - 24 minutes - 22.4 MB - ★★★★★ - 4 ratingsMental Health Health & Fitness substance abuse therapy psychiatry mental health treatment substance abuse treatment Homepage Download Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
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The paper we discuss in this episode is V Popova et al. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined with a Newly Initiated Oral Antidepressant in Treatment Resistant Depression: A Randomized Double-Blind Active-Controlled Study. Am J Psychiatry 2019; 176(6): 428-438.
For a deeper understanding of the factors that contribute to placebo response, check out BR Rutherford and SP Roose. A Model of Placebo Response in Antidepressant Clinical Trials. Am J Psychiatry 2013; 170:723-733.
Lots of data about the placebo response in antidepressant clinical trials: