Live Longer World
36 episodes - English - Latest episode: 10 days ago -The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future.
https://livelongerworld.substack.com/
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Episodes
Michael Levin & Richard Nuccitelli | History of Bioelectricity & Solving Cancer
May 02, 2024 18:23 - 1 hour - 59.4 MBThis is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer. E...
FDA History and Breast Cancer Drug Controversy | Dr. Mikkael Sekeres
April 24, 2024 18:09 - 1 hour - 59.5 MBDr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin. We discuss: - The history of the FDA, - The trial of Avastin which got FDA approval in 2008 and revoked in 2011 - FDA's funding mechanisms - FDA ties to big pharma - What can be improved about the FDA and the criticisms it receives Episode Show Notes: https://livelonger...
#27 Women's Reproductive Aging, Menopause, & Hormone Replacement Therapy | Dr. Jennifer Garrison
November 08, 2023 17:41 - 1 hour - 57.8 MBDr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer. Episode Show Notes: https://livelongerworld.com/p/jgarrison Find the previous podcast episodes & subscribe to be notified: https://livelonger...
#26 Scaling Laws in Longevity & Aging | Dr. Geoffrey West, Author of book Scale
June 29, 2023 17:53 - 2 hours - 113 MBDr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity. Episode Show Notes: https://livelongerworld.substack.com/p/gwest Find the previous podcast episodes & subscribe to be...
#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad
August 04, 2022 15:38 - 1 hour - 62.8 MBAll platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad...
#24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2)
June 28, 2022 14:56 - 1 hour - 63.8 MBAll platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share a...
#23 Dominic D'Agostino | Ketogenic Diet for Brain Health and Longevity (Part 1)
June 09, 2022 14:46 - 56 minutes - 51.8 MBAll platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share a...
#22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous
May 24, 2022 14:42 - 1 hour - 58 MBAll platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is nam...
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev
May 10, 2022 14:10 - 1 hour - 55.2 MBAll platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls...
#20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss
May 03, 2022 18:37 - 1 hour - 65.8 MBDr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more. If you want to understand how to think about you...
#19 Michael Levin | Can Bioelectrical Signals Reverse Aging?
April 19, 2022 15:15 - 1 hour - 55.4 MBDr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology. His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is co...
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller
April 12, 2022 15:48 - 1 hour - 74.8 MBDr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I ...
#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin
March 08, 2022 16:10 - 1 hour - 57.6 MBYuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming. Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it i...
# 16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams
March 01, 2022 15:37 - 1 hour - 63.6 MBDr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today’s episode, you will learn: Cellular Senescence and it’s dual r...
#16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams
March 01, 2022 15:37 - 1 hour - 63.6 MBDr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today’s episode, you will learn: Cellular Senescence and it’s dual r...
#15 Parkinson's Disease & Mitochondrial Dysfunction | Andy Lee, COO Vincere Biosciences
February 22, 2022 15:36 - 50 minutes - 46.1 MBMy guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whet...
#14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells
February 15, 2022 15:14 - 55 minutes - 51.1 MBMy guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA ...
#13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging
February 08, 2022 13:19 - 1 hour - 77.8 MBMy guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the ...
#12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging
February 01, 2022 15:22 - 27 minutes - 25.4 MBMy guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas! Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insuff...
#11 Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats
January 25, 2022 17:06 - 58 minutes - 53.5 MBMy guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. In today's discussion, we spoke about the network concept of t...
#10 Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging
January 18, 2022 07:17 - 1 hour - 57 MBMy guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene. Think ...
#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis
January 11, 2022 13:32 - 50 minutes - 45.8 MBMy guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchang...
#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research
January 04, 2022 15:56 - 1 hour - 56.6 MBDr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying...
#07 2021 Best of Live Longer World | Longevity Science
December 21, 2021 05:15 - 54 minutes - 49.9 MBThe final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more. And if a particular topic or clip captures your attention, you can ...
#06 Morgan Levine | Epigenetic Clocks, SystemsAge Clock and Epigenetic Reprogramming
November 30, 2021 14:30 - 1 hour - 69.2 MBDr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. I can’t even begin to tell you how much I learned in today’s conversation! We extensively discussed Morgan’s work on developing a new Epigenetic clock called the SystemsAge clo...
#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
November 17, 2021 13:00 - 1 hour - 86.6 MBDr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive con...
#05 Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project | Matt Kaeberlein
November 17, 2021 13:00 - 1 hour - 86.6 MBDr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive con...
#04 Longevity Funding, Regenerative Medicine & Longevity Escape Velocity | Dave Methuselah, Founder & CEO of Methuselah Foundation
November 11, 2021 12:00 - 58 minutes - 54.2 MBMy guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah i...
#04 Dave Gobel, Founder & CEO of Methuselah Foundation | Longevity Funding, Regenerative Medicine & Longevity Escape Velocity
November 11, 2021 12:00 - 58 minutes - 54.2 MBMy guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah i...
#03 Skin Aging, OneSkin, and Building a Longevity Company with Carolina Oliveira, the founder & CEO of OneSkin Technologies
November 03, 2021 17:22 - 1 hour - 55.6 MBCarolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais...
#03 Carolina Oliveira, the founder & CEO of OneSkin Technologies | Skin Aging, OneSkin, and Building a Longevity Company
November 03, 2021 17:22 - 1 hour - 55.6 MBCarolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais...
#02 Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!) with Dr. Jean Hebert, Professor of Neuroscience at Albert Einstein College of Medicine
October 26, 2021 15:27 - 1 hour - 60.1 MBJean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializ...
#02 Dr. Jean Hebert | Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!)
October 26, 2021 15:27 - 1 hour - 60.1 MBJean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializ...
#01 How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis with Reason, the Founder & CEO of Repair Biotechnologies
October 12, 2021 17:30 - 1 hour - 60 MBReason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most...
#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis
October 12, 2021 17:30 - 1 hour - 60 MBReason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most...
Introducing Live Longer World
October 04, 2021 21:55 - 1 minute - 1.25 MB"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!" Well then, you're at the right spot! Hello and welcome to Live Longer World! The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advoc...