#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.   

Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!  

As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.  

In today’s episode, you will learn: 

- The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging) 

- Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state  

- What is it and what are the open questions in the field 

- What are the cancer risks associated with it 

- Why Yuri believes in Cryonics 

- Why Yuri got interested in uncovering the COVID-19 Lab Leak theory  

- Pharma in Russia

If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

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YURI DEIGIN LINKS: 

Twitter: https://twitter.com/ydeigin

LinkedIn: https://www.linkedin.com/in/yurideigin/

Medium: https://yurideigin.medium.com/

YouthBio Therapeutics: https://youthbiotx.com/ 

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TIMESTAMPS: 

00:00 "We're not crazy" 

0:37 100% life extension & translation to humans 

4:28 Aging is potentially an engineering problem 

12:45 Strong Epigenetic Theory of Aging 

19:26 Epigenetic Reprogramming 

29:00 Risk of Cancer with Epigenetic reprogramming 

33:00 Rejuvenation without cancer risk? 

38:30 Why Cryonics Makes Sense 

48:00 COVID Lab Leak Theory 

53:45 Pharma in Russia 

58:40 Optimism in Longevity 

1:00:50 Aging is Universal. Let's Unite in this Fight

Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.