#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.   

Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.  

It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!  

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VADIM GLADYSHEV LINKS: 

Website: https://gladyshevlab.bwh.harvard.edu/2022 

Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 

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TIMESTAMPS: 

0:00 Vadim Gladyshev Intro 

1:28 Live Longer World 

2:17 Selenium’s dual role in aging (the good, the bad, the ugly) 

11:27 Antagonistic Pleiotropy 

13:53 Selenium & Cancer 

15:58 Selenium Dosage (don’t get too much!) 

18:30 Reactive Oxygen Species, Antioxidants & Aging 

22:30 Fundamental basis of Aging 

24:09 Aging is damage 

29:20 Single cell Epigenetic Clocks 

34:22 Aging in the Womb 

42:16 Parent’s lifestyle for aging in embryo 

44:14 Rapamycin during development 

49:06 Other compounds 

51:53 Slowing Aging vs. Rejuvenation 

56:08 New projects being worked on 

57:17 Confidence level in extending lifespan within 30 years 

59:17 Support Live Longer World  

Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

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Aging is universal. Let's unite in this fight. Stay in good health - Aastha.