Heart Disease Masterclass - Tom Dayspring, M.D. – Part 3: Cholesterol Lowering Medication

In this series, Dr Thomas 'Tom' Dayspring, M.D., one of the world's most recognised experts in lipidology, shares his breadth of knowledge on heart disease prevention.

Part 3 covers the types of cholesterol lowering medication, as well as testing for hyper absorbers of cholesterol.

Plenty of Tom's personal illustrations, diagrams & graphics included. You can test your knowledge by having a go at the quiz below. 

00:00 Intro
04:58 Cholesterol absorption in gut 
06:22 Fecal excretion of cholesterol 
06:54 Sterols & xenosterols 
09:41 Niemann-Pick C1-Like 1 Protein & ATP-binding cassette transporter G5/G8  
11:23 Synergy between NPC1L1 & ATP-binding cassette transporter G5/G8    
12:47 Hyper absorption of cholesterol 
13:19 Ezetimibe 
14:09 Free cholesterol & cholesterol ester 
16:13 CD36 Receptor for fatty acids 
16:35 Cholesterol of hepatobiliary origin 
18:15 Is dietary cholesterol a risk factor  ? 
18:50 Tests for hyper absorbers & phytosterols 
20:02 Ezetimibe for hyper absorbers 
21:27 Stanols, gut bacteria & benecol  
24:59 Excess cholesterol within HDL particles in hyper absorbers 
27:35 Ezetimibe as an add-on or first-line therapy 
28:38 The failure of niacin & fibrates 
29:27 Statins & the inhibition of cholesterol synthesis 
30:35 Potential downsides to statins 
34:23 Bempedoic acid 
37:50 PCSK9 inhibitors for nightmare ApoB 
45:56 Inclisiran PCSK9 (Leqvio) 
47:24 Lipoprotein(a) 
51:10 Outro  

Interactive quiz:  https://forms.office.com/Pages/ResponsePage.aspx?id=jM-h1o52h0GnOLblDE3rStdKkvg0Y_NMm65uD3dzrKpUNFFYNjZSTjZKUkRYNUVZWUpGMUw2RTIzSi4u  Give Tom a follow on Twitter: https://twitter.com/Drlipid

Give Tom a follow on Twitter: https://twitter.com/Drlipid

Other appearances from Tom: 

Drive Podcast 

https://www.youtube.com/watch?v=PllTHYgWpuwWellness: 

Fact vs. Fiction 

https://podcasts.apple.com/us/podcast/a-masterclass-in-cholesterol-and-lipid-lowering/id1447250475?i=1000581954971

Nutrition Made Simple 

lp(a): https://www.youtube.com/watch?v=-WRRyG8il4g

Dietary cholesterol: https://www.youtube.com/watch?v=GkWMDnTyxfo

Coronary Calcium Score (CAC): https://www.youtube.com/watch?v=gxIeRUbHauw 

Narrative glossary on lipids provided by Tom: https://peterattiamd.com/glossary-lipids/

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