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Mind & Matter

910 episodes - English - Latest episode: 3 days ago - ★★★★★ - 15 ratings

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:

Taking ownership of your health starts with taking ownership of your information diet.All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

“Γνῶθι σεαυτόν” (Know thyself)“Μηδὲν ἄγαν” (Nothing in excess)“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

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Episodes

Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson | M&M #139

February 14, 2024 08:00 - 1 hour - 69.6 MB

Send us a Text Message. About the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution." Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more. *This content is never meant to serve as medical advice. Support the Show. All epis...

Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | #138

February 09, 2024 08:00 - 1 hour - 77.8 MB

Send us a Text Message. Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more. Support the Show. All epi...

Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | M&M #138

February 09, 2024 08:00 - 1 hour - 77.8 MB

Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more. Support the Show. All episodes (audio & video), sh...

Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll

February 09, 2024 08:00 - 1 hour - 77.9 MB

Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more. Support the show All episodes (audio & video), sho...

DMT, Serotonin, Inflammation, Psychedelics, and Past, Present & Future of Psychedelic Medicine | David & Charles Nichols | #137

February 06, 2024 01:00 - 1 hour - 67.1 MB

Send us a Text Message. Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketamine, and other psychoactive drugs; and more More M&M content about psychedelic science: https://substack.com/search/psychedelics?focusedPublicat...

DMT, Serotonin, Inflammation, Psychedelics, and Past, Present & Future of Psychedelic Medicine | David & Charles Nichols | M&M #137

February 06, 2024 01:00 - 1 hour - 67.1 MB

Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketamine, and other psychoactive drugs; and more More M&M content about psychedelic science: https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=fo...

Seed Oils, Omega-6 PUFAs, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | #136

January 23, 2024 03:00 - 1 hour - 64.5 MB

Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more. Click here for more M&M content about diet & metabolism: https://substack.com/search...

Seed Oils, Omega-6 Fats, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | M&M #136

January 23, 2024 03:00 - 1 hour - 64.5 MB

Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more. Click here for more M&M content about diet & metabolism: https://substack.com/search...

Seed Oils, Omega-6 Fats, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | #136

January 23, 2024 03:00 - 1 hour - 64.5 MB

Send us a Text Message. Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more. Click here for more M&M content about diet & metabolism: ht...

History of Diet Trends & Medical Advice in the US, Fat & Cholesterol, Seed Oils, Processed Food, Ketogenic Diet, Can We Trust Public Health Institutions? | Orrin Devinsky | #135

January 10, 2024 22:00 - 1 hour - 69.5 MB

Send us a Text Message. Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity & diabetes; sugars, fructose, and metabolic health; ketogenic diet & ketosis; whether or not we can trust our public health institutions; and mo...

History of Diet Trends & Medical Advice in the US, Fat & Cholesterol, Seed Oils, Processed Food, Ketogenic Diet, Can We Trust Public Health Institutions? | Orrin Devinsky | M&M #135

January 10, 2024 22:00 - 1 hour - 69.5 MB

Send us a Text Message. Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity & diabetes; sugars, fructose, and metabolic health; ketogenic diet & ketosis; whether or not we can trust our public health institutions; and mo...

Omega-6-9 Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | #134

January 03, 2024 22:00 - 1 hour - 60.1 MB

Send us a Text Message. Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more. More content on the science of diet & metabolic health: http...

Omega-6-9 Fats, Vegetable & Seed Oils, Sucrose, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | M&M #134

January 03, 2024 22:00 - 1 hour - 60.1 MB

Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more. Download a free digital copy of her book: https://www.mdpi.com/books/mono/5908-the-he...

Omega-6-9 Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | M&M #134

January 03, 2024 22:00 - 1 hour - 60.1 MB

Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more. More content on the science of diet & metabolic health: https://substack.com/search/d...

Omega-6-9 Fats, Vegetable & Seed Oils, Sucrose, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | #134

January 03, 2024 22:00 - 1 hour - 60.1 MB

Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more. Download a free digital copy of her book: https://www.mdpi.com/books/mono/5908-the-he...

Infant Microbiome & Breast Milk, Oral Microbiome & Cavities, Gut Health, Fiber, Probiotics, Diet, Sex Hormones, Soy Foods & Estrogens | Carolina Tropini | #133

December 20, 2023 22:00 - 1 hour - 66.8 MB

Send us a Text Message. Dr. Carolina Tropini is an assistant professor of Microbiology & Immunology at the University of British Columbia, where her lab studies the microbiome in health & disease. Topics covered: infant & vaginal microbiome, breast milk nutrients & C-sections vs. natural births; oral microbiome & cavities; gut microbiome & irritable bowel disease (IBD); fiber, short-chain fatty acids & probiotics; how gut bacteria influence sex hormones (estrogen, testosterone) in the body;...

Infant Microbiome & Breast Milk, Oral Microbiome & Cavities, Gut Health, Fiber, Probiotics, Diet, Sex Hormones, Soy Foods & Estrogens | Carolina Tropini | M&M #133

December 20, 2023 22:00 - 1 hour - 66.8 MB

Dr. Carolina Tropini is an assistant professor of Microbiology & Immunology at the University of British Columbia, where her lab studies the microbiome in health & disease. Topics covered: infant & vaginal microbiome, breast milk nutrients & C-sections vs. natural births; oral microbiome & cavities; gut microbiome & irritable bowel disease (IBD); fiber, short-chain fatty acids & probiotics; how gut bacteria influence sex hormones (estrogen, testosterone) in the body; and more. More content ...

Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John Speakman | M&M #132

December 05, 2023 22:00 - 1 hour - 50.3 MB

Dr. John Speakman is a biologist whose research focuses on energy balance, energy expenditure, genetic and environmental drivers of obesity and the energetic contribution to aging. They discuss: the history of the obesity epidemic in the US vs. China; changes in patterns of physical activity, diet, and energy expenditure in humans over time; how saturated fats vs. PUFAs affect basal metabolism; the relative contributions of fats, carbs, and protein to fat & weight gain; and more. See this c...

Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John Speakman | #132

December 05, 2023 22:00 - 1 hour - 50.3 MB

Send us a Text Message. Dr. John Speakman is a biologist whose research focuses on energy balance, energy expenditure, genetic and environmental drivers of obesity and the energetic contribution to aging. They discuss: the history of the obesity epidemic in the US vs. China; changes in patterns of physical activity, diet, and energy expenditure in humans over time; how saturated fats vs. PUFAs affect basal metabolism; the relative contributions of fats, carbs, and protein to fat & weight ga...

Dietary Fat, Cholesterol, Cardiovascular Health & Disease, Carbohydrates, Dietary Guidelines, Food Industry & Diet Research | Ronald Krauss | #131

December 04, 2023 22:00 - 1 hour - 79.1 MB

Send us a Text Message. Nick talks to Dr. Ronald Krauss, a physician and researcher at UCSF who studies the relationship between diet & cardiometabolic health. They discuss: saturated vs. unsaturated fats; carbohydrates & fat synthesis; "good" vs. "bad" cholesterol; official US dietary guidelines and how they're established; funding of research by the food industry; and more. More content on the science of diet & metabolic health: https://substack.com/search/diet%20metabolism?focusedPublic...

Dietary Fat, Cholesterol, Cardiovascular Health & Disease, Carbohydrates, Dietary Guidelines, Food Industry & Diet Research | Ronald Krauss | M&M #131

December 04, 2023 22:00 - 1 hour - 79.1 MB

Nick talks to Dr. Ronald Krauss, a physician and researcher at UCSF who studies the relationship between diet & cardiometabolic health. They discuss: saturated vs. unsaturated fats; carbohydrates & fat synthesis; "good" vs. "bad" cholesterol; official US dietary guidelines and how they're established; funding of research by the food industry; and more. More content on the science of diet & metabolic health: https://substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=...

Cognitive Neuroscience, Cognitive Flexibility & Control, Attention, Working Memory, Multitasking & Behavior | Tobias Egner | #130

November 05, 2023 20:00 - 1 hour - 50.2 MB

Send us a Text Message. Dr. Tobias Egner is a Professor of Psychology & Neuroscience at Duke University, where his lab studies cognition, working memory, and cognitive control & flexibility. They discuss: what cognition is and how it's studied experimentally; working memory & attention; cognitive flexibility, cognitive control & multitasking; memory, perception, and predictive coding; and more. To learn more about neuroscience, check out this content: https://substack.com/search/neuroscien...

Cognitive Neuroscience, Cognitive Flexibility & Control, Attention, Working Memory, Multitasking & Behavior | Tobias Egner | M&M #130

November 05, 2023 20:00 - 1 hour - 50.2 MB

Dr. Tobias Egner is a Professor of Psychology & Neuroscience at Duke University, where his lab studies cognition, working memory, and cognitive control & flexibility. They discuss: what cognition is and how it's studied experimentally; working memory & attention; cognitive flexibility, cognitive control & multitasking; memory, perception, and predictive coding; and more. To learn more about neuroscience, check out this content: https://substack.com/search/neuroscience?focusedPublicationId=5...

Biological Sex, Sexual Selection, Sex Behavior, Mating Strategies, Sexual Orientation, Monogamy & Polygyny | David Puts | M&M #129

October 22, 2023 07:00 - 1 hour - 74.1 MB

Dr. David Puts is a biological anthropologist at the Penn State University. His research focuses on the evolution and development of human sexuality and sex differences. They discuss: the biological basis of sex; gametes, sex chromosomes & sex hormones; the development of sexual orientation; the evolution of sexual dimorphism & behavior in primates; monogamy & polygyny; and more. Support the show Find all podcast & written content at the M&M Substack: [https://mindandmatter.substack.com/?sor...

Biological Sex, Sexual Selection, Sex Behavior, Mating Strategies, Sexual Orientation, Monogamy & Polygyny | David Puts | #129

October 22, 2023 07:00 - 1 hour - 74.1 MB

Send us a Text Message. Dr. David Puts is a biological anthropologist at the Penn State University. His research focuses on the evolution and development of human sexuality and sex differences. They discuss: the biological basis of sex; gametes, sex chromosomes & sex hormones; the development of sexual orientation; the evolution of sexual dimorphism & behavior in primates; monogamy & polygyny; and more. Support the Show. All episodes (audio & video), show notes, transcripts, and more at t...

Peripheral Nervous System in Health & Disease, Gut Health & Enteric Nervous System, Exercise & Neuroplasticity | Moses Chao | #128

October 16, 2023 17:00 - 1 hour - 50 MB

Send us a Text Message. Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise...

Psychedelics, Microdosing Psilocybin, Stress Resilience, Anxiety & Obsessive Compulsive Disorder | Mikael Palner | M&M #127

October 11, 2023 21:00 - 59 minutes - 40.5 MB

Send us a Text Message. Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more. More psychedelic science content: https://substa...

Psychedelics, Microdosing Psilocybin, Stress Resilience, Anxiety & Obsessive Compulsive Disorder | Mikael Palner | #127

October 11, 2023 21:00 - 59 minutes - 40.5 MB

Send us a Text Message. Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more. More psychedelic science content: https://substa...

Evolution of Human Behavior, Anatomy & Diet, Homo naledi & the Cave of Bones | John Hawks | M&M #126

August 28, 2023 01:00 - 2 hours - 85.5 MB

Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus, and other species; the latest discoveries related to Homo naledi, which was the subject of the Netflix documentary, "Cave of Bones." To learn more about evolution, check out these episodes: https://substack.com/search/evolution?focusedPublicationId=513528&searching=focu...

Evolution of Human Behavior, Anatomy & Diet, Homo naledi & the Cave of Bones | John Hawks | #126

August 28, 2023 01:00 - 2 hours - 85.5 MB

Send us a Text Message. Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus, and other species; the latest discoveries related to Homo naledi, which was the subject of the Netflix documentary, "Cave of Bones." To learn more about evolution, check out these episodes: https://substack.com/search/evolution?focusedPublicatio...

Anxiety, Obsessive Compulsive Disorder, Microglia, From Being a WWII Orphan to the Nobel Prize | Mario Capecchi | M&M #125

August 21, 2023 18:00 - 1 hour - 69.8 MB

Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more. Sup...

Anxiety, Obsessive Compulsive Disorder, Microglia, From Being a WWII Orphan to the Nobel Prize | Mario Capecchi | #125

August 21, 2023 18:00 - 1 hour - 69.8 MB

Send us a Text Message. Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring s...

Hormonal Contraception, Sex Hormones, Menstruation, Pregnancy, Puberty, Estrogens, Androgens, Effects of Birth Control on Cognition | Adriene Beltz | #124

August 15, 2023 07:00 - 1 hour - 61 MB

Send us a Text Message. Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more. Support the Show. All episo...

Hormonal Contraception, Sex Hormones, Menstruation, Pregnancy, Puberty, Estrogens, Androgens, Effects of Birth Control on Cognition | Adriene Beltz | M&M #124

August 15, 2023 07:00 - 1 hour - 61 MB

Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more. Support the show Sign up for the free weekly Mind & Ma...

Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Cannabis & Effects of Marijuana on Brain Development | Matthew Hill | M&M #123

August 10, 2023 00:00 - 1 hour - 62.1 MB

Send us a Text Message. Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more. See previous episode with Dr. Matthew Hill: https://mindandmatter.substack.com/p/matthew-hill-endocannabinoid-s...

Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Cannabis & Effects of Marijuana on Brain Development | Matthew Hill | #123

August 10, 2023 00:00 - 1 hour - 62.1 MB

Send us a Text Message. Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more. See previous episode with Dr. Matthew Hill: https://mindandmatter.substack.com/p/matthew-hill-endocannabinoid-s...

Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | #122

August 02, 2023 18:00 - 1 hour - 52.2 MB

Send us a Text Message. Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more. Support the Show. All episodes (audio & video), show notes, ...

Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | M&M #122

August 02, 2023 18:00 - 1 hour - 52.2 MB

Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more. Support the Show. All episodes (audio & video), show notes, transcripts, and more at ...

Psychedelics, Metaplasticity, Critical Periods, Social Learning, Psilocybin, LSD, MDMA, Ketamine, Ibogaine & Neuroscience | Gül Dölen | M&M #121

July 19, 2023 20:00 - 1 hour - 70.5 MB

Send us a Text Message. Nick talks to Gül Dölen, MD, PhD, a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addic...

Psychedelics, Metaplasticity, Critical Periods, Social Learning, Psilocybin, LSD, MDMA, Ketamine, Ibogaine & Neuroscience | Gül Dölen | #121

July 19, 2023 20:00 - 1 hour - 70.5 MB

Send us a Text Message. Nick talks to Gül Dölen, MD, PhD, a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addic...

Psychedelics, Depression, Psychotherapy, SSRIs, Human Clinical Experience of Psychedelic Medicine | Alan Davis | #120

July 11, 2023 21:00 - 1 hour - 46.3 MB

Send us a Text Message. Nick talks to Dr. Alan Davis, a clinical psychologist and Director of the Center for Psychedelic Drug Research & Education at Ohio State University. They discuss: the effectiveness of mainstream forms of psychotherapy and antidepressant medications (SSRIs) for depression; psychedelic medicine & psilocybin-assisted psychotherapy; the relevance of the subjective effects of psychedelics for their therapeutic effects; FDA approval for MDMA- and psilocybin-assisted psycho...

Psychedelics, Neuroplasticity, LSD, Psilocybin, Ketamine, MDMA, Latest Psychedelic Science | Bryan Roth | #119

July 06, 2023 21:00 - 1 hour - 53.1 MB

Send us a Text Message. Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psych...

Psychedelics, Neuroplasticity, LSD, Psilocybin, Ketamine, MDMA, Latest Psychedelic Science | Bryan Roth | M&M #119

July 06, 2023 21:00 - 1 hour - 53.1 MB

Send us a Text Message. Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psych...

Psychedelics, Terence McKenna, Psilocybin Mushrooms, DMT, Carl Jung, Culture, Drugs & Society | Dennis McKenna | #118

June 28, 2023 23:00 - 1 hour - 62 MB

Send us a Text Message. Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. #psychedelics #psilocybin #DMT #plantmedicine #ethnobot...

Terence McKenna, Psychedelics, Psilocybin Mushrooms, DMT, Carl Jung, Culture, Drugs & Society | Dennis McKenna | M&M #118

June 28, 2023 23:00 - 1 hour - 62 MB

Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. Support the show Find all podcast & written content at the M&M Substack: [https:/...

Psychedelics, Terence McKenna, Psilocybin Mushrooms, DMT, Carl Jung, Culture, Drugs & Society | Dennis McKenna | M&M #118

June 28, 2023 23:00 - 1 hour - 62 MB

Send us a Text Message. Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. #psychedelics #psilocybin #DMT #plantmedicine #ethnobot...

Terence McKenna, Psychedelics, Psilocybin Mushrooms, DMT, Carl Jung, Culture, Drugs & Society | Dennis McKenna | #118

June 28, 2023 23:00 - 1 hour - 62 MB

Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. Support the show Find all podcast & written content at the M&M Substack: [https:/...

Psychiatry, Psychedelic Medicine, LSD for Anxiety, MDMA for Autism, Medical Education, Patient Access & Mental Health | Daniel Karlin | #117

June 09, 2023 22:00 - 1 hour - 66.9 MB

Send us a Text Message. Nick talks to Daniel Karlin, MD, a board-certified physician in psychiatry, addiction medicine & clinical informatics who is the Chief Medical Officer at MindMed. They discuss: psychiatry; incentives in scientific & medical research; healthcare & mental health; psychedelics; LSD for anxiety; MDMA for autism; ibogaine derivatives for addiction; patient access & care; and more. *This content is never meant to serve as medical advice. Support the Show. All episodes (...

Psychiatry, Psychedelic Medicine, LSD for Anxiety, MDMA for Autism, Medical Education, Patient Access & Mental Health | Daniel Karlin | M&M #117

June 09, 2023 22:00 - 1 hour - 66.9 MB

Nick talks to Daniel Karlin, MD, a board-certified physician in psychiatry, addiction medicine & clinical informatics who is the Chief Medical Officer at MindMed. They discuss: psychiatry; incentives in scientific & medical research; healthcare & mental health; psychedelics; LSD for anxiety; MDMA for autism; ibogaine derivatives for addiction; patient access & care; and more. Support the Show. All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athleti...

The Dirty Truth About Cooking Oils (Avocado, Olive, Vegetable Oil) | Selina Wang | #116

June 01, 2023 22:00 - 1 hour - 58 MB

Send us a Text Message. Nick talks to chemist & food scientist Dr. Selina Wang about: food quality & purity; cooking oils (avocado, olive, vegetable, etc.); fruits & vegetables; oxidation & purity of cooking oils; how to identify high quality, pure foods to purchase; and more. Try Everyday Dose, high-quality coffee & matcha alternatives with functional mushrooms & other supplements. Support the Show. All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Tr...

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