Big Brains

What Dogs Are Teaching Us About Aging, with Daniel Promislow

Every dog owner has faced the hard realization that their dog won’t live as long as they do, but we’ve all probably wondered: Why do some dogs live longer than others? It turns out that several factors are at play, according to the largest research study of dogs, known as The Dog Aging Project. Prof. Daniel Promislow of the University of Washington is co-director of the project, which examines how biology, lifestyle and environment can increase both the health and lifespan of more than 50,0...

Where Has Alzheimer’s Research Gone Wrong? with Karl Herrup

For more than a century, scientists have been studying Alzheimer’s disease and developing theories about its underlying cause. The leading theory for decades has been that abnormal amyloid plaques in the brains of those who suffer from the disease are the central cause. But, according one renowned Alzheimer’s researcher, this myopic focus is not only flawed, but may be holding back our search for a cure.  Neurobiologist Karl Herrup argues that we need to go back to the drawing board, redefi...

Why Breeding Millions of Mosquitoes Could Help Save Lives

Mosquito-borne diseases are one of the greatest global health threats, infecting around 700 million people every year with Zika virus, dengue fever, malaria and yellow fever — which can all be deadly if left untreated. Unfortunately, the mosquito population is not slowing down, and factors like climate change and increased global travel are broadening the mosquito's range. The effort to stop the mosquito is not an easy task; insecticides and vaccines can't completely stop the spread of these...

Why Shaming Other Countries Often Backfires, with Rochelle Terman

How do you stop a government from continuing to commit human rights abuses? You could take them to an international court of justice, or file a complaint at the UN. But none of those bodies have any enforcement power. Short of going to war, the only option on the table in most international situations is to name and shame. But is that strategy effective? In her new book, “The Geopolitics of Shaming: When Human Rights Pressure Works and When It Backfires,” University of Chicago political sci...

Can Trump Legally Be President?, with William Baude

The Supreme Court’s decision on whether Colorado can take former President Donald Trump off the ballot in the 2024 election may be one of the most consequential in its history. The case will turn on the court’s interpretation of Amendment 14, Section 3 of the Constitution, which bars any previous elected official from holding office if they participated in an insurrection. When making their case, Colorado followed the logic of a law review article co-authored last year by University of Chica...

What Our Hand Gestures Reveal About Our Thoughts, with Susan Goldin-Meadow

Language shapes our world. But when we speak, there is actually a secret conversation happening beyond our words. It’s happening not with our mouths—but with our hands. Prof. Susan Goldin-Meadow is a distinguished scholar of psychology at the University of Chicago. Her research into deaf children who were never taught sign language led her to studying why the gestures we do all day may contain more information about our minds than we realize. Now she’s included all her insights in a new boo...

Psychedelics Without Hallucinations: A New Mental Health Treatment? with David E. Olson

The United States is facing a real mental health crisis. In the last few years, one possible treatment has gotten a lot of press: psychedelic drugs. But what is actually happening in a person’s brain when they take a psychedelic? Could understanding the biology and the chemistry allow us to make better and safer versions of these drugs—and maybe even create psychedelics without the hallucinations? In this episode, we speak with Assoc. Prof. David E. Olson, founding director of the UC Davis ...

The Science Of Happiness

The Big Brains team is taking some time off during the holidays but for all those travelers out there heading home, we wanted to make sure you still had your favorite podcast in your feed. So, we’re resharing one of our most popular episodes ever. It’s about the science of happiness. What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted. Beginning in 1938, th...

Do We Really Have Free Will? With Robert Sapolsky

Here’s the question you’re going to be asking for the next 30 minutes: Did I freely choose to listen to this podcast, or did I actually have no choice at all? Most of us probably believe we have free will. We feel like we make decisions, and that each of us is responsible for the consequences of our actions. But what if that’s all just an illusion? Robert Sapolsky is a renowned professor of biology and neurology at Stanford University, but he’s also the author of best-selling scientific boo...

A Radical Solution To Address Climate Change, with David Keith

Climate change can feel like an impossible crisis these days. Every week there is some new report about the irreversible damage we’re doing to our planet and the havoc it will bring to people’s lives. We all know cutting emissions is the solution, yet governments and companies seem no closer to meeting the goals that scientists say we must hit. It can feel hopeless. There is one possible controversial solution to climate change many in the mainstream haven’t discussed. It’s so controversial...

How PFAS “Forever Chemicals” Are Harming Our Health, with Linda Birnbaum

By now, you've probably heard about the dangers of PFAS “forever chemicals.” These chemicals are all around us—they're in waterproof hiking boots, electronics, nonstick pans and even our drinking water—but there's no way for them to break down in our environment. Epidemiological studies have linked to these chemicals to numerous diseases—from kidney cancer, liver cancer, obesity, decreased fertility and more. American toxicologist Linda Birnbaum has been sounding the alarms about how PFAS a...

Are We Worse People Than We Used To Be? With Adam Mastroianni

How many times have you heard this phrase: “Back in the day, people were nicer” or “People aren’t as kind as they used to be?” Most of us have experienced the feeling that people are becoming meaner over time, year after year. But is it true? Are people really less kind than they used to be? That’s the question that has bothered psychologist Adam Mastroianni most of his life. He set out to find an answer—a search that recently culminated in a paper published in the journal Nature titled, “T...

Freakonomics’ Steven Levitt On The Secret To Making Tough Choices

Of the academic books that have become household names, “Freakonomics” must be at the top of the list. The 2005 book by University of Chicago scholar Steven Levitt and journalist Stephen Dubner created not only a whole new way of thinking about discovering answers to complex problems, but launched a media empire—from book sequel to a movie to a hit podcast. On this special episode, we sat down with Levitt during the inaugural UCPN Podcast Festival, to talk about the legacy of Freakonomics. ...

Will Political Violence Destroy Our Democracy?, With Robert Pape

Since the Jan. 6, 2021 attack on the U.S. Capitol, University of Chicago Prof. Robert Pape has been closely observing the threats to our democracy. Now, the renowned terrorism expert says that violent ideas coming from a dedicated minority are moving from fringe to mainstream. In 2021, Pape's team along with NORC at the University of Chicago launched the Dangers to Democracy tracker, an ongoing series of surveys to track Americans' thoughts and attitudes about political violence. In one rec...

Defending Campus Free Speech In A Polarized Age, with Paul Alivisatos and Tom Ginsburg

Free speech is probably one of the most polarizing public topics of debate. And those arguments only become more intense when it comes to free expression on college and university campuses. Should professors be allowed to say whatever they want? What about speakers being invited to campus? Who gets to say what is acceptable and unacceptable? The University of Chicago has had a unique and long history of defending free expression, and this year is building upon that commitment by launching T...

Why The Secret To Health Lies In The Mind-body Connection, with Ellen Langer

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer. Langer is a bit of a legend. She’s the first woman to ever receive tenure in psychology at Harvard, and her work has earned her the moniker: “The Mother of Mindfulness”. Her 40-year research career into t...

Phonics Vs. Whole Word: The Science Of Reading, With Adrian Johns

Reading is one of the most significant practices in the modern age of information, but it has a complicated history. Scientists began studying reading over a century ago; they built eye movement devices to study how fast and efficiently we read, and even proposed methods on the best ways to teach kids how to read. But all of this well-intentioned science led to various debates, from America's Reading Wars to today's anti-elite and anti-science movement.  In a new book, The Science of Readin...

How AI Is Transforming Scientific Research, With Rebecca Willett

One of the first areas to be affected by AI has been science. Researchers have already started to integrate these new technologies into their work, but what does it mean to let these systems into our labs? Can they be trusted? And, if they so, how radically can they push science forward? Prof. Rebecca Willett is the faculty director of AI at the University of Chicago Data Science Institute. She is at the forefront of thinking through how AI will change science, and in this episode, she exam...

How AI Could Change The Law

AI promises to change every part of our society, but one area that has already started to be affected is law. And AI may do more than just upend the profession of lawyers. One professor here at the University of Chicago believes that, with its ability to handle massive data sets, AI could be used to entirely change the law itself, making it personal for every individual based on how they live their lives. It’s a radical idea, but one we may need to start confronting sooner rather than later....

How AI Can Predict Future Scientific Discoveries

Science is facing a perplexing problem. Although there are far more scientists today than ever before, publishing research at a faster and faster pace, new and novel advancements have slowed not increased. But one expert at the University of Chicago thinks he may have found a way out of this progress standstill…artificial intelligence. In the last few months AI has become the number one topic on everyone’s mind. This is the first episode of a three part series on the ways today's researcher...

The Uncovered History of Space Travel & Its Privatized Future

Everyone is talking about the upcoming summer blockbuster, Oppenheimer. We are always incredibly captivated by behind the curtain looks at some of the most momentous events in our history. Uncovering the secret details and hidden motivations of the people that have shaped our past. And all the buzz got me thinking about a fascinating prior episode of our show that did just that. You may think you know the history of space travel, from Sputnik to NASA to our recent shift toward privatized sp...

The Health Costs of Air Pollution

Many cities in the US have been experiencing smoky and hazy skies lately. Some of you have probably been affected by poor air quality due to the ongoing wildfires in Canada that are causing pollution to travel as far as Chicago and New York. On a former episode of our podcast, we spoke with some of the leading experts on air pollution about how this problem has been getting worse and the cost we’re all paying for it. We’re taking a summer break while we work on some special episodes and wil...

How Your Brain Benefits From Music, With Larry Sherman

Music plays an important role in all of our lives. But listening to music or playing an instrument is more than just a creative outlet or hobby — it’s also scientifically good for us. Research shows that music can stimulate new connections in our brains; keeping our cognitive abilities sharp and our memories alive. In a new book entitled Every Brain Needs Music: The Neuroscience of Making and Listening to Music, Prof. Larry Sherman explores why we all need music for our mental wellbeing — a...

Magic words: Can What You Say Help You Get Your way? with Jonah Berger

Everyone wishes they had a superpower. Well, it turns out you’ve had a secret power since you were a child, you just don’t know how to use it yet. That’s the power of language. In a fascinating new book, “Magic Words: What To Say To Get Your Way," Prof. Jonah Berger of the Wharton School uses massive data sets and machine learning to tease out the “magic words” that can transform our lives. Could changing just a single word in your mind help you stick to that diet? Could mastering when to s...

Providing Basic Health Insurance For Every American, With Katherine Baicker

If there is something both sides of the political aisle can agree on, it’s that there is something deeply wrong with health insurance in the United States. What they can’t agree on is how to fix it. The right blames everything on the Affordable Care Act, while those on the left say we need Healthcare For All. But what if there was another option? In a recent paper published in JAMA, leading health economist and University of Chicago Provost Katherine Baicker lays out an innovative blueprint...

Why We Fight, With Christopher Blattman

Why do we fight? It’s a seemingly simple question, but it turns out the answers are surprising, deep and crucial to understanding our world. Considering how costly any conflict is in lives and money, why do wars happen at all? This is one of those episodes that will change how you view some of our most important issues, from the war in Ukraine, to understanding gang fights, and even a possible conflict with China. We’re taking the week off to work on some truly special episodes coming out i...

The Hidden Truths About Sexuality And Gender In The Medieval World, with Roland Betancourt

We often think our debates around sexuality and gender are a modern phenomenon. Some people argue that identities like trans and non-binary have only existed recently. But could the evidence for queer and gender-nonconforming lives actually stretch back centuries?  In a recent book entitled Byzantine Intersectionality, Prof. Roland Betancourt of the University of California-Irvine uncovers an overlooked history from the Byzantine era. His work shows how surprisingly modern medieval conversa...

How We Could Regrow Limbs And Organs, with Michael Levin

In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricity—electrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are built—and how it could be the future of regenerative medicine.  Levin is professor of biology at Tufts Universi...

A Nobelist’s Controversial Approach To Solving Inequality, With James Heckman

Over his distinguished career, Nobel Prize-winning economist James Heckman has dedicated his research to understanding and solving the problem of inequality. He has closely studied how investing in early childhood development is linked to better outcomes—from higher earnings, to violence reduction, and even breaking the cycle of poverty. His groundbreaking research has been applied across the globe—from Jamaica to Denmark and China, and it has given policymakers important insights into educ...

How The Food Industry Created Today’s Obesity Crisis, With Marion Nestle

In today's grocery stores, you can find more sugary snacks, artificial ingredients, and ultra-processed packaged foods. At the same time, the United States has seen an increase in obesity, which is costing our healthcare system, too. Nutritionist Marion Nestle says the problem today isn't that Americans don't know how to eat healthy, rather the food environment that we live in has made it much harder to do so. In this episode, she discusses what policy changes are needed—from the way food s...

Why Your Gut Health Is So Important, With Cathryn Nagler And Eric Pamer

Link to the advertised Chicago Booth Review podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-cap-camp:podcast23-20230320     

Why Mourning Is Essential To Our Well-Being, With Jonathan Lear

Mourning is an inevitable part of our human existence. But what exactly does it mean to mourn, and why is it an essential part of our well-being and survival? These questions have long fascinated Prof. Jonathan Lear, a philosopher at the University of Chicago. In his new book, Imagining the End: Mourning and Ethical Life, Lear unpacks why mourning contributes to a life well lived. He dissects the many ways we mourn in our everyday lives; when attachments are taken away from us, and even when...

The History of Black Cinema Re-examined, With Jacqueline Stewart

The Scientific Secret To A Happy Life, With Marc Schulz

What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted. Beginning in 1938, the Harvard Study of Adult Development tracked three generations of families to uncover what contributed to their happiness. In their new book, The Good Life: Lessons from the World's Longest Scientific Study of Happiness, Robert Waldinger and Marc Schulz tell the stories behind their pa...

Unraveling Sleep’s Greatest Mysteries: The Day Tomorrow Began

Almost a century ago, the origins of sleep science research began at the University of Chicago with the opening of the world's first sleep laboratory. Since then, sleep science has evolved into a multi-disciplinary field — with scientists focusing on diagnosing the causes of sleep disorders, to how sleep affects our metabolic health, and improving methods for good sleep hygiene. But at the core of sleep science, one fundamental question remains: Why do we sleep? In our special series, The Da...

Is The U.S. Headed Toward Another Civil War? Feat. William Howell

As we approach the second anniversary of the Jan. 6 attack on the U.S. Capitol, we wanted to reflect on a few questions that many Americans are asking these days: Is democracy on the brink of the collapse? Why are U.S. politics so polarized? And are we headed for another civil war? These questions seem incredibly daunting, so we wanted to understand what the data really tell us. William Howell, a University of Chicago professor and director of the Center for Effective Government, has been t...

Follow Through On Next Year's Resolutions Using Science With Katy Milkman

As we head into 2023, many of us are setting our new year's resolutions and new goals for the year. It can be hard to stick to these resolutions or accomplish these goals, but there's a technique we can use to help us. We wanted to re-release our episode with Katy Milkman, a behavior scientist who wrote the best-selling book, How To Change: The Science of Getting From Where You Are To Where You Want To Be. Katy Milkman is a professor at The Wharton School of the University of Pennsylvania, ...

Why Quantum Tech Will Change Our Future: The Day Tomorrow Began

In the last few years, we’ve witnessed the birth of an entirely new field of science: quantum technology. With the power to create unbreakable encryption, supercharge the development of AI, and radically expedite the development of drug treatments, quantum technology will revolutionize our world. Today is the day our quantum future is beginning. But what will the future look like, and what do we need to do to get there? In the latest edition of our special series The Day Tomorrow Began, w...

Fighting Global Hunger Through Genetics With Chuan He

We’re taking the week off to spend the holidays with our families, but we think this is a perfect moment to re-release one of our most important episodes. As we all dig into our delicious Thanksgiving dinners, we need to remember that not everyone is so lucky. Global hunger is still a massive problem facing our society. By 2050 humanity will have to make 50% more food in order to feed a growing population. That’s a lot, especially since we currently have trouble feeding the current population...

The Origins Of Civilization And The Future Of Archaeology: The Day Tomorrow Began

When you name your special series The Day Tomorrow Began, you inevitably have to ask yourself: just how far back are we going to go? If there’s one group of scholars who could tell us what the earliest possible day that “tomorrow” began is, it’s archaeologists. On this episode, we go back in time to learn about James Henry Breasted, a UChicago scholar who in the early 20th century revolutionized the field, founded the world-renowned Oriental Institute (the OI) and uncovered the roots of anc...

Can We Predict Your Capacity To Focus? With Monica Rosenberg

It can seem like our culture is obsessed with our ability to focus. Why can’t we focus, how we can focus better, why is our lack of focus ruining society? There are best-selling books and apps that promise to teach us the secrets of paying attention. But what do we really know about what’s happening in the brain when we’re focused or not? In a fascinating set of studies, University of Chicago neuroscientist Monica Rosenberg is using fMRIs to study the science of attention and answer all sor...

The 'Legendary' Discovery Of Black Holes: The Day Tomorrow Began

Sometimes the biggest moments in scientific history happen in the most unlikely places. There’s no better example than the story of Nobel Prize-winning scientist Subrahmanyan Chandrasekhar, a longtime University of Chicago scholar whose pioneering research paved the way to the discovery of black holes. Chandrasekhar’s story is the first in a special series called “The Day Tomorrow Began,” in which we will examine the historical origins of some of the most breakthrough ideas to happen at the...

Celebrating Our 100th Episode

This episode marks the official 100th episode of the Big Brains podcast. To celebrate this milestone, our Senior Producer Matt Hodapp joins host Paul M. Rand for a behind-the-scenes conversation about the philosophy behind the program, their favorite moments, as well as where the podcast has been—and where it’s going.

The Science Of Speech & Identity With Katherine Kinzler

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. The way we talk is not something we spend a lot of time thinking about. But, when it comes to communicating, what we’re saying may only be as important as how we say it. That’s what Prof. Katherine Kinzler of the University of Chicago...

Life’s Mysterious Origins With Jack Szostak

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. What are the biggest questions in science today: Can we cure cancer, solve the climate crisis, make it to Mars? For Nobel laureate Jack Szostak, the biggest question is still much more fundamental: What is the origin of life? Jack Szos...

The Afterlife Of Mass Incarceration With Reuben Jonathan Miller

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. For the more than 20 million people with a felony record, incarceration doesn’t end at the prison gate. They enter what University of Chicago scholar Reuben Jonathan Miller calls the “afterlife” of mass incarceration. Miller, an assist...

The Imbalance In Our Society With Raghuram Rajan

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. This week, we look back at our episode with UChicago economist, Raghuram Rajan. He became infamous for predicting the 2008 financial collapse three years before it happened. Rajan says that there are three pillars in our society: the s...

Does Welfare Reduce Crime? With Manasi Deshpande

There have been myths and tropes about welfare since it was created. We often hear critics say that welfare discourages people from working — but are these claims really true? This debate often plays out through theory and anecdotes, yet it’s rare to get good data about the true effects of welfare. A groundbreaking paper by University of Chicago economist Manasi Deshpande does just that. It’s a first-of-its-kind study that tells a clear story about the life-long effects of one kind of welfar...

The Crucial Race To Build A Better Battery With Shirley Meng

Batteries have revolutionized our lives, especially the invention of rechargeable batteries, which have enabled us to have cellphones, laptops, and electric vehicles. But as we transition to more forms of green energy, we're facing a serious dilemma: Will our current lithium-ion batteries be able to sustain us? Battery scientist Shirley Meng says we need to explore different metals and elements that could last longer and charge faster. Meng is a chief scientist at the Argonne National Labora...

Do Animals Dream? With David M. Peña-Guzmán

Do animals dream? If you’re a pet owner, it may seem obvious that your furry friends dream. Most of us have seen dogs running in their sleep or cats meowing during a nap. But this is an academic podcast and really proving that animals dream isn’t so simple. In his new book, When Animals Dream: The Hidden World of Animal Consciousness, philosopher David M. Pena-Guzman of San Francisco State University argues the science shows that animals really do dream, and that those dreams are evidence of...