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ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means

Authentic Biochemistry

English - May 12, 2023 00:35 - 30 minutes - 27.8 MB - ★★★★★ - 10 ratings
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Previous Episode: ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
Next Episode: ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.

References


Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15


J Mol Endocrinol. 2020 Nov; 65(4): R77–R90.


REDOX and Cholesterol metabolism lectures-Dr Guerra



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