Authentic Biochemistry artwork

ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites

Authentic Biochemistry

English - May 10, 2023 21:38 - 29 minutes - 27.1 MB - ★★★★★ - 10 ratings
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Previous Episode: ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
Next Episode: ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means

References


Cancers (Basel). 2019 May; 11(5): 678.


Oncogene.2017 Mar 23; 36(12): 1607–1618


Dr Guerra's annotated lecture notes from graduate biochemistry course(s)

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