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ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD

Authentic Biochemistry

English - May 10, 2023 00:12 - 29 minutes - 27.6 MB - ★★★★★ - 10 ratings
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Previous Episode: ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
Next Episode: ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites

References


Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9


Cancer Drug Resist 2020;3:762-74.


Oncogene.2017 Mar 23; 36(12): 1607–1618


Front Immunol. 2020; 11: 1782.

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