This Week in Virology
665 episodes - English - Latest episode: 1 day ago - ★★★★★ - 2K ratingsThis Week in Virology is a netcast about viruses - the kind that make you sick.
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Episodes
TWiV 923: If a bat pees in a forest, does anyone care?
July 31, 2022 04:00 - 1 hour - 37.7 MBFrom The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events. Hosts: Vincent Racaniello and Brianne Barker Guests: Vincent Munster and Raina Plowright Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novel Hendra virus variant in Australia (E...
TWiV 922: TWiV clinical update with Dr. Daniel Griffin
July 30, 2022 04:00 - 42 minutes - 24.7 MBIn his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, sta...
TWiV 920: Science will break your heart
July 24, 2022 04:00 - 1 hour - 35.5 MBFrom ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Pamela Bjorkman and Andy Mehle Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bjorkman laboratory Mehle laboratory Finding the groove (Nat Immunol) S...
TWiV 921: COVID-19 clinical update #124 with Dr. Daniel Griffin
July 23, 2022 04:00 - 35 minutes - 20.6 MBIn COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant vaccine boosters trial (medRxiv...
TWiV 919: Motivated by volatiles
July 17, 2022 04:00 - 1 hour - 58.7 MBTWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the lon...
TWiV 918: COVID-19 clinical update #123 with Dr. Daniel Griffin
July 16, 2022 04:00 - 40 minutes - 23.7 MBIn COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva...
TWiV 917: Boosters on, Paul Offit
July 10, 2022 04:00 - 1 hour - 59.6 MBPaul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 28 June 2022 VRBPAC meeting m...
TWiV 916: COVID-19 clinical update #122 with Dr. Daniel Griffin
July 09, 2022 04:00 - 47 minutes - 27.6 MBIn COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding o...
TWiV 915: Mouse mouth to mouse mom
July 03, 2022 04:00 - 1 hour - 66.3 MBTWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory ...
TWiV 914: COVID-19 clinical update #121 with Dr. Daniel Griffin
July 02, 2022 04:00 - 37 minutes - 21.8 MBIn COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Becom...
TWiV 913: Twinkle twinkle little SARS
June 26, 2022 04:00 - 1 hour - 67.3 MBTWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliovirus in UK sewage (ProMedMail and Science) P...
TWiV 912: COVID-19 clinical update #120 with Dr. Daniel Griffin
June 25, 2022 04:00 - 45 minutes - 26.3 MBIn COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants. Subscribe (free): Apple Podcasts, Go...
TWiV 911: Antibody can get vaccinated now
June 19, 2022 04:00 - 1 hour - 66.1 MBTWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hepatitis of unknown etiology (MMWR) Clinical recognition of monkeypox (CDC)...
TWiV 910: COVID-19 clinical update #119 with Dr. Daniel Griffin
June 18, 2022 04:00 - 46 minutes - 27.2 MBIn COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (...
TWiV 909: Art of science
June 16, 2022 10:35 - 47 minutes - 33 MBFrom ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks (TWiV 352) Timestamps by Jole...
TWiV 907: When the cats and mice are away, the viruses play
June 12, 2022 04:00 - 1 hour - 60.4 MBTWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse mo...
TWiV 908: COVID-19 clinical update #118 with Dr. Daniel Griffin
June 11, 2022 04:00 - 46 minutes - 27 MBIn COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine ...
TWiV 906: Long COVID, giant viruses, and smallish pox
June 05, 2022 04:00 - 1 hour - 61.2 MBTWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MM...
TWiV 905: COVID-19 clinical update #117 with Dr. Daniel Griffin
June 04, 2022 04:00 - 44 minutes - 25.9 MBIn COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen...
TWiV 904: 50 years of reverse transcriptase
May 29, 2022 04:00 - 58 minutes - 34.2 MBVincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore, John Coffin, and Harold Varmus Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th ...
TWiV 903: COVID-19 clinical update #116 with Dr. Daniel Griffin
May 28, 2022 04:00 - 47 minutes - 27.8 MBIn COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir a...
TWiV Special: Monkeypox clinical update with Dr. Daniel Griffin
May 26, 2022 15:08 - 26 minutes - 15.3 MBIn this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment (pdf, ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for...
TWiV 902: Autoantibodies drive severe COVID-19
May 22, 2022 11:34 - 2 hours - 72.9 MBTWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin...
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
May 21, 2022 13:10 - 1 hour - 34.9 MBIn COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without va...
TWiV 900: Burning down the mouse
May 15, 2022 04:00 - 1 hour - 55 MBTWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene. Thanks! Weekly Pic...
TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
May 14, 2022 04:00 - 55 minutes - 32.5 MBIn COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eff...
TWiV 898: Immunity is skin deep
May 08, 2022 04:00 - 1 hour - 56.7 MBTWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases...
TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
May 07, 2022 04:00 - 47 minutes - 27.8 MBIn COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a pat...
TWiV 896: Memory B cells, the way we were
May 01, 2022 04:00 - 1 hour - 58.8 MBTWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters rea...
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
April 30, 2022 04:00 - 35 minutes - 20.8 MBIn COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Autho...
TWiV 894: Dinner with the TMPRSS family
April 28, 2022 23:41 - 1 hour - 57.6 MBTWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 (TWiV 879) Letters ...
TWiV 893: Yellow fever virus escapes antibodies
April 24, 2022 04:00 - 1 hour - 51.1 MBKartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ...
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
April 23, 2022 04:00 - 54 minutes - 31.5 MBIn COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Polit...
TWiV 891: LLOV in the time of Ebola
April 21, 2022 04:00 - 1 hour - 48.8 MBElke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious ...
TWiV 890: Looking into a booster crystal ball
April 17, 2022 04:00 - 1 hour - 66.3 MBThis episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 b...
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
April 16, 2022 04:00 - 53 minutes - 30.9 MBIn COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron ...
TWiV 888: Molnupiravir with Richard Plemper
April 14, 2022 04:00 - 1 hour - 51.9 MBRichard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of ...
TWiV 887: Bonfire of the monocytes
April 10, 2022 13:08 - 1 hour - 62.5 MBTWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a domi...
TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin
April 09, 2022 04:00 - 39 minutes - 23 MBIn COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccin...
TWiV 885: Russian bats and Ankara vectors
April 07, 2022 04:00 - 1 hour - 60 MBTWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) MVA vectored COVID vaccine (Sci Immunol) Letters re...
TWiV 884: Cytokines and viral mimicry
April 03, 2022 04:00 - 2 hours - 70.2 MBVincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene. Than...
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
April 02, 2022 04:00 - 45 minutes - 26.4 MBIn COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booste...
TWiV 882: Elispot on about T cells and lipids
March 31, 2022 04:00 - 1 hour - 126 MBVincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to i...
TWiV 881: 50 ways to zap your virus
March 27, 2022 04:00 - 1 hour - 64.7 MBTWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) Prome...
TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin
March 26, 2022 04:00 - 47 minutes - 54.8 MBIn COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambi...
TWiV 879: Indolent, resistant, and losing our TMPRSS
March 24, 2022 04:00 - 1 hour - 114 MBTWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) Ho...
TWiV 878: Shape matters sometimes
March 20, 2022 14:21 - 2 hours - 71.5 MBTWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CWD in meadow voles and raccoons (Emerg Inf Dis) Unusual infectious...
TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin
March 19, 2022 04:00 - 28 minutes - 16.6 MBIn COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this...
TWiV 876: Spillover market with Michael Worobey
March 17, 2022 04:00 - 1 hour - 111 MBMichael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michael Worobey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan (TWiV 833) Huanan market was epicenter of COVID-19 (Zenodo) Two sp...
TWiV 875: Animal house
March 13, 2022 05:00 - 1 hour - 53.4 MBTWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO declaration of COVID-19 pandemic Virome of China game animals (Cell) ACE2 binding is ancestral and evolvable (Nature) Letters read on TWiV 875 Timestamps ...