Indiana Hoosiers vs Michigan State Spartans Picks and Predictions

Indiana Hoosiers vs Michigan State Spartans betting picks, predictions and odds for their Big Ten Football showdown on Saturday, October 16 2021 at 12:00pm ET from Memorial Stadium in Bloomington, Indiana. Michigan State remains one of the last unbeaten teams in the country. Can the Spartans keep their run going against a feisty Indiana squad? Direct from Las Vegas, our panel of professional sports handicappers look at the Vegas odds and offer their expert college football analysis on this NCAAF Week 7 clash between the Hoosiers and Spartans. At the time of posting, the WagerTalk Live Odds screen is showing Michigan State as a 5-point road favorite at Indiana, with the over/under sitting at 48.5 points.