Vital Science
50 episodes - English - Latest episode: 12 days ago - ★★★★★ - 22 ratingsLife science is complicated, but its mission is simple – to create a safer, healthier future. This podcast tells the stories behind the science from the perspective of patients, scientists, employees, and advocates that have felt its impact.
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Episodes
Mission Therapeutics: Inhibiting DUBs to Halt Diseases
April 16, 2024 08:00 - 17 minutes - 24 MBAt Mission Therapeutics, Sarah Almond serves as their Head of Pharmacology, but she wears many hats to help develop potential treatments for neurodegenerative conditions. Their main area of focus centers around research into deubiquitinating enzymes (DUBs), which may impact neurodegeneration. By studying DUBs, Sarah and her team have been able to generate highly targeted and potent molecules that contribute to developing safe and effective therapeutics. In fact, one of thes...
Clear Scientific: Combatting the Opioid Epidemic
March 26, 2024 12:00 - 32 minutes - 45.4 MBOpioid use in the United States has exploded into a nationwide crisis. Users who want to get clean and rid themselves of methamphetamine, cocaine, and/or fentanyl often find it difficult, essentially “chaining” themselves into a cycle of drug use that’s mostly impossible to break. However, what if there was a drug that could eliminate toxins and restore normal bodily function within minutes? That’s the aim of Clear Scientific, a small biotech in Cambridge, MA that’s curr...
Cure Rare Disease: Continuing a Legacy
February 20, 2024 18:21 - 35 minutes - 49.6 MBWhen he founded Cure Rare Disease in 2018, Rich Horgan was primarily focused on finding a treatment for his younger brother Terry, who had an ultra-rare form of Duchenne Muscular Dystrophy (DMD). Suffering from a disease that has no cure, Terry served as a “selfless, brave, and courageous” figure that Rich continues to draw inspiration from when seeking new, innovative solutions to treat this progressive, neurodegenerative condition. Join us for this interview as Rich di...
H-Guard: Improving Physical and Mental Health
January 16, 2024 09:00 - 28 minutes - 38.8 MBFor the 850 million people around the world suffering from chronic kidney disease, the grind of dialysis treatment can wear them down in more ways than one. Dr. Andy Herbert, co-founder of Invizius, is out to change that. This five-year-old company started from humble beginnings and is currently developing H-Guard® Priming Solution, which increases the effectiveness of dialysis while negating, or eliminating, its potentially dangerous side effects. It will be used in an upcom...
Checking Vitals: The Disruptors
December 19, 2023 09:00 - 10 minutes - 14.3 MBOver the past 12 months, we have shared some remarkable stories from the scientific community, but three of the most impactful have come from “Disruptors” in their respective fields. Relive these stories with our hosts on the year-end edition of Vital Science. Show Notes The Disruptors: Conversations in Science Meet Valerie Meet Wise Charles River | Gene Therapy for Neurological Disorders In Vitro and In Vivo Model of Amyotrophic Lateral Sclerosis https://www.criver....
TREND: The Online Community Making a Difference
November 14, 2023 09:00 - 44 minutes - 61.6 MBWhen Maria Picone’s daughter was diagnosed with Prader-Willi Syndrome (PWS), she turned to the internet for answers. What she found was an online community of caregivers sharing their experiences with PWS, giving her comfort and direction with what to do about her daughter’s rare disease. It also spurred her and her husband to create TREND Community, an online platform for caregivers of rare diseases to not only share their experiences, but also make positive contributions to ...
Strength in Numbers
October 17, 2023 16:49 - 54 minutes - 74.5 MBImagine a world where your child has a rare disease that’s so rare, it doesn’t have a name and only a handful of people around the world have a similar condition. It can leave you feeling helpless and alone knowing the odds are stacked against you. This is the situation Bo Bigelow experienced with his daughter, Tess. She suffers from a USP7, a neurodevelopmental disorder that impacts her motor function, speech, and bone development. Tess’ condition left Bo looking for help… and...
Emily Whitehead: Pioneer and Hero
September 19, 2023 08:00 - 33 minutes - 46.2 MB18-year-old Emily Whitehead aspires to be a writer, but nothing could have prepared her for the plot twist that struck her as a child. In the space of just 24 hours, five-year-old Emily suffered from various symptoms that culminated in a diagnosis of acute lymphoblastic leukemia (ALL). After almost two years of failed chemotherapy treatments, her family turned towards an experimental CAR-T therapy that had been successful with adults but never been used on a child. Three weeks...
Modernizing Drug Development
July 18, 2023 08:00 - 25 minutes - 35.8 MBFor decades, researchers have utilized animal models to help predict the effects of a drug compound in humans. With recent advances in technology and the passage of the FDA Modernization Act 2.0, researchers are increasingly looking at new methods to refine, reduce, and replace in vivo testing to advance drug candidates. However, one important question remains – how are all these modern advancements and laws driving progress in drug discovery? Find out as Michael Templin...
SCA3: A Family Affair
June 20, 2023 14:36 - 23 minutes - 32.9 MBSpinocerebellar ataxia type 3 (SCA3) is a neuromuscular disease affecting just 50,000 people in the United States, including three generations of the Klassen family. Greg Klassen, his father, and his son have all been diagnosed with this rare condition that impacts the central nervous system, affecting balance, coordination, and mood. Motivated by the 50/50 chance his son Jeff will develop its unforgiving symptoms, Greg joined the board of the Cure Rare Disease foundation and ...
Moving FAST to Treat Angelman Syndrome
May 16, 2023 08:00 - 30 minutes - 42.4 MBThe effects of Angelman Syndrome (AS) on young children are debilitating. From an early age, they face an uphill battle with this neurogenetic disease’s unrelenting symptoms, including seizures, cognitive impairments, and loss of motor function. It can also be tough on caretakers – just ask Dr. Allyson Berent and Jennifer Panagoulias. They both have personal connections to this disease, which in Dr. Berent’s case led to her creating the Foundation for Angelman Syndrome Therapeutic...
Free for Life: The Story of n-Lorem Foundation
April 18, 2023 08:00 - 30 minutes - 42.3 MBWhen patients face the diagnosis of a rare disease, they face a costly, uphill battle to develop a treatment for their condition… that is, if they ever do. Dr. Stanley Crooke is aiming to change that. As the CEO of n-Lorem Foundation, his mission is to provide personalized treatments to ultra-rare disease patients for free as long as they live, no questions asked. Thanks to his humility, coupled with the generosity of other individuals and companies, ultra-rare disease patient...
Evie's Story Revisited
March 21, 2023 08:00 - 29 minutes - 40.4 MBImagine being diagnosed with an incurable rare disease before ever being born. This is the reality that Evie faced when she was diagnosed with hypophosphatasia, a condition impacting bone growth, breathing, and mobility, and often gives patients just 18 months to live. Luckily, her story doesn’t end there. At three months old, she enrolled in a clinical trial for a first-of-its-kind medication that her mom Lindsey claims “probably saved her life”. Today, Evie is 13 years old ...
Neurogenesis: Regenerating Hope
February 21, 2023 09:00 - 27 minutes - 38 MBCould it be possible to regenerate neurons in the human body? It’s a question that has driven Dr. Wise Young for over 40 years. He’s dedicated his career to researching spinal cord injuries and how to develop a treatment for them. Along the way, he’s discovered neurogenesis, a way to regenerate neurons in not just the spinal cord, but also the brain. Thanks to his work, what everybody told him was once impossible, is now close to becoming a reality. Join us as Dr. Young d...
AviadoBio: Bold and Courageous
January 17, 2023 09:00 - 31 minutes - 43 MBRecent advancements in research has led to the development of effective therapeutics to combat neurodegenerative diseases, giving patients a renewed sense of hope there will ultimately be a more effective treatment. CEO Lisa Deschamps and her team at AviadoBio are among those conducting research in the space, but they’re doing things a little differently. They’ve been given a unique drug designation by the FDA to develop a treatment for frontotemporal dementia (FTD), a crippling ne...
Checking Vitals
December 13, 2022 09:00 - 15 minutes - 21.9 MBAs we close in on the end of 2022, we’ve had the privilege to interview some amazing people who are doing great work with drug discovery. Join Gina Mullane and Todd Poley as we reflect on some of the memorable moments and guests from this season, including an update on Amylyx Pharmaceuticals’ new ALS treatment, Chris Claussen’s discussion on the positive impacts of psychedelic drugs, and the work of Project ALS to develop a treatment for this crippling disease. On behalf of ou...
A Father’s Race Against Time
November 15, 2022 09:00 - 29 minutes - 40.9 MBSpastic Paraplegia 50 (SPG50) is a neurodegenerative and neurodevelopmental disorder that is known to affect only 80 people around the world, including just one person in Canada. Unfortunately for Terry Pirovolakis, it happens to be his son, Michael. As a result, he’s teamed up with gene therapy experts, CROs, and nonprofits to research, manufacture, and deliver a therapy to help his son and others suffering from this ultra-rare disease, but the clock is ticking. Join u...
Project ALS: Fueled by Love
September 20, 2022 08:00 - 35 minutes - 48.6 MBFor Valerie Estess, finding a cure for ALS is personal. Her sister, Jenifer, was diagnosed with this crippling disease in 1998, which led to the founding of Project ALS, a nonprofit designed to raise awareness and eventually find a cure. Nearly 25 years later, they have raised over $100 million and helped develop Jacifusen, the first therapy designed to help treat ALS. However, Valerie believes their work is far from finished. Join us for an intimate discussion on the origins of P...
Logica– Drug Discovery Made Smarter
July 19, 2022 08:00 - 35 minutes - 48.6 MBWhat happens when you combine an industry-altering, AI-powered platform with a leading CRO's preclinical expertise? That’s what Valo Health and Charles River are answering with the introduction of Logica™. This revolutionary platform aims to accelerate drug discovery and development by finding the most viable molecules faster, helping biotechs and pharma focus their resources only on the ones that will evolve into therapies that patients will receive more quickly. Join Gu...
Retrogenix: The Screen Door of Drug Development
June 21, 2022 08:00 - 19 minutes - 27.3 MBDrug developers face long odds and complex regulatory challenges when it comes to crafting a suitable candidate. In fact, only one of every 10 drug candidates gain regulatory approval, and when they do, it takes an average of 14 years and costs well over $2 billion. So what makes for a successful candidate? It starts with a suitable screening platform that identifies targets and the molecules that bind to them to create a therapeutic response. Retrogenix is one such platform t...
Open Science: The Parallel Universe
May 17, 2022 08:00 - 28 minutes - 25.9 MBAled Edwards’ vision of science is set to shake the foundation of drug discovery and development as we know it. The Director of M4K Pharma and CEO of the Structural Genomics Consortium is leading the charge for a more open scientific approach. It’s a parallel universe where scientists can work together and get therapies designed to treat rare diseases in the hands of patients even faster – one that isn’t bound by patents, siloes, and profits. Join Aled as he discusses the...
(Re)programming Stem Cells for Drug Development
April 19, 2022 08:00 - 27 minutes - 25.7 MBA medic by trade, Mark Kotter has always held a particular interest in neuroscience and stem cell research. As founder and CEO of bit.bio, he's overseen the development of a unique approach to "reprogram" stem cells and change them into consistent and scalable disease-relevant cells, which can then be screened for potential therapeutics to help treat such diseases as Huntington's Alzheimer's, and ALS. Hear about this revolutionary technology and how it works, what benefits it can ...
Are we One Shot Away?
March 15, 2022 08:00 - 21 minutes - 20.2 MBImagine a gene therapy treatment that gives drug-resistant focal epilepsy patients more control over their seizures and ultimately improve their quality of life? We sat down with Karin Agerman to discuss this possibility and discovered that her work at Combigene is at the forefront of a novel gene therapy called CG01. Find out how this single-injection therapy is giving renewed hope to this patient population and learn more about CombiGene’s research into CG01. SHOW NOTES Cell a...
Can Psychedelic Drugs Really Boost Brain Health?
February 15, 2022 09:00 - 36 minutes - 33.4 MBWhen Chris Claussen’s grandfather succumbed to the crippling effects of Alzheimer’s disease, he knew that it could be coming for him in due time. From then on, he has made it a “personal crusade” to look at what some may call an unconventional method to improve brain health and overall mood – microdosing psychedelic drugs. By combining first-hand experience with laboratory research, he noticed a correlation between the two, but questions and scrutiny still remain as to its effectiv...
From Humble Beginnings to Potential Treatment for ALS
January 18, 2022 09:00 - 33 minutes - 30.7 MBIn March 2020, we invited Josh Cohen and Justin Klee on Vital Science to discuss Amylyx Pharmaceuticals, a company that had one simple mission – to improve the quality of life for those battling neurodegenerative diseases. Since their humble beginnings, what was once a company with less than ten employees has grown exponentially. Get the latest from Josh and Justin as they rejoin our podcast to discuss the new drug application process for AMX0035, what they’ve learned from their...
Donors: The Unsung Heroes Advancing Science
December 21, 2021 09:00 - 15 minutes - 14.3 MBThe role of human cells and tissues is key in the development of next-generation therapies. With just a few samples, donors contribute to scientific advancements in medicine. This is especially true with cell and gene therapy, a field that is projected to grow over the next several years, and with it comes the growing need to find reliable and recallable donors willing to help those in need. In our latest episode of Vital Science, learn more about the critical role these unsung hero...
Can MILs Strike a Killer Blow to Cancer?
October 19, 2021 08:00 - 28 minutes - 26.5 MBFrom a young age, Kim Noonan knew what she wanted in life — a career in science and a desire to help. When her mother succumbed to gastric cancer, it drove her even more to help people, especially cancer patients. Today, she’s at the forefront of a potentially game-changing development in cancer therapy — using bone marrow-infiltrating lymphocytes (MILs) designed to target and kill cancerous tumors of all shapes and sizes. Find out how her early work with myeloma patients started ...
A Synergistic Approach to Treating Huntington’s Disease
September 21, 2021 08:00 - 32 minutes - 29.8 MBHuntington’s disease may only affect one in every 10,000 people in the United States, but its symptoms can drastically debilitate a person’s quality of life. For Ignacio Muñoz-Sanjuan, he witnessed first-hand the devastating effects this disease can have. He’s visited parts of the world that have the highest prevalence of Huntington’s disease on the planet, including Taiwan and South America. Today, he’s involved with two different nonprofit organizations seeking to accelerate the ...
Opening Treatments
July 20, 2021 08:00 - 38 minutes - 30.8 MBSanath Ramesh was determined to track down the resources needed to repurpose a drug for his son Raghav’s ultra-rare disease. This determination led him to apply his experiences and empower the rare disease community with his collaborative platform, the OpenTreatments Foundation. Find out how his repurposed drug platform is now giving hope to other rare disease patients. EPISODE LINK OTHER RESOURCES: Open Treatments Repurposing Compound Libraries High-Throughput Screening ...
Standing on the Shoulders of Giants
June 15, 2021 08:00 - 30 minutes - 24.8 MBWhat if it was possible to speed up drug development without having to reinvent the wheel? By repurposing existing drugs, drug hunters are taking a giant step forward towards changing the future of drug discovery. Join our panel of drug hunters to hear how they reinvent previously approved drugs to get a head start towards treating patients. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane and Chris Garcia Special thanks to: Ian Waddell Vad Lazari Bar...
Can a Repurposed Drug Be the Answer?
May 18, 2021 08:00 - 46 minutes - 37.1 MBWhat if the cure for your untreatable disease was just waiting on the shelf at your neighborhood pharmacy? Join physician, patient, and researcher Dr. David Fajgenbaum as he shares how his unexpected battle with Castleman disease set him on a journey to find his cure and develop new ways of using existing drugs. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane Special thanks to: Dr. David Fajgenbaum Barbara Killian
The Life (Saving) Blood of Horseshoe Crabs
April 20, 2021 08:00 - 43 minutes - 35.1 MBThe discovery of limulus amebocyte lysate (LAL) in the blood of horseshoe crabs has forever changed bacterial endotoxin testing. Today, researchers continue to look for any way they can protect these seafaring creatures while refining testing methods to decrease the need for animals. Join our panel for an in-depth look at how they’re working with legislators to preserve the horseshoe crab population and how LAL testing is the safest in vitro method to detect harmful bacteria. Ac...
3D Cell Models: A Blueprint for Drug Development
March 16, 2021 08:00 - 28 minutes - 23.4 MBThree-dimensional cell models are primed to play a vital role in the future of drug development. By recreating tissue that mimics human systems, scientists can monitor disease progression and evaluate the effects of drug candidates. Join Drs. Elizabeth Anderson and Ian Waddell as they explain the evolution of biologic modeling and how 3D cell models are being used to develop effective therapeutics to patients. Acknowledgements: Hosted by: Gina Mullane Narrated by: Chris Garcia...
Driving Drug Development with CRISPR/Cas9
February 16, 2021 09:00 - 26 minutes - 24.5 MBWithin the past decade, CRISPR/Cas9 gene editing of mammalian cells has become common practice, but does it hold the key to unlocking future of therapeutic development? Join Dr. David Fischer and our panel for a detailed look at the advantages and applications of this Nobel Prize-winning technology. Acknowledgements: Hosted by: Gina Mullane Narrated by: Chris Garcia Special thanks to: Dr. David Fischer
Get the Series Recap: Vaccines
January 19, 2021 09:00 - 3 minutes - 3.2 MBGet your four-part dose of vaccine…information, that is. In this brief recap, Vital Science hosts Gina Mullane and Chris Garcia chat about the content of our first several Season 2 episodes – a miniseries covering infectious disease and immunity, origins of vaccination, therapeutic development and regulation, and the scientific community’s recent accomplishments in the fight against COVID. Download individual episodes: See what you might have missed in the vaccine series or do...
COVID-19 Vaccines – Behind the Scenes
December 15, 2020 09:00 - 20 minutes - 18.9 MBRecent developments in the race to develop a COVID vaccine show promise, but the question remains – when will it become available to the general public? Dr. Sarah Gould returns for the fourth and final installment of our vaccine miniseries to examine where we stand with the development of COVID-19 vaccines and some lingering challenges that may hamper their final approval. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane Special thanks to: Dr. Sa...
Beyond the Headlines: Understanding Accelerated Vaccines
November 17, 2020 09:00 - 23 minutes - 21.5 MB“Accelerating” a vaccine for COVID-19 has piqued the interest of many, but is it really possible to develop one quickly and safely? Join distinguished scientist Dr. Lauren Black as she dives into the typical mechanisms behind a vaccine and why it takes several years to deliver one safely to the general public. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane Special thanks to: Dr. Lauren Black
A Formidable Defense Against Infectious Diseases
October 20, 2020 08:00 - 46 minutes - 37.7 MBWhen the immune system is compromised, people rely on vaccines to eliminate and inactivate the threat. However, the process with which this happens is anything but simple. Dr. Christina Satterwhite joins us to explain how the immune system works and how vaccines target harmful pathogens in the second installment of our series on vaccines. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane Special thanks to: Dr. Christina Satterwhite
Infectious Disease and The Rise of Vaccines
September 22, 2020 08:00 - 19 minutes - 15.9 MBSince 1796, vaccines have helped humans combat smallpox, the flu, and other infectious diseases. The process of vaccine development has changed drastically since then, and is now front and center in the wake of COVID-19. In the first episode of our series on vaccines, join us as we talk with Dr. Sarah Gould about the history of vaccines and infectious disease. Acknowledgements: Hosted by: Chris Garcia Narrated by: Gina Mullane Special thanks to: Dr. Sarah Gould
Two in the Same
July 21, 2020 08:00 - 41 minutes - 33.4 MBCate and Laura Cheevers are sisters who were both born with cystic fibrosis. Together, they’ve been through multiple clinical trials for genotype-specific treatments and continue to defy the odds. Hear their unique tales of growing up with this rare genetic disorder and how it’s shaped their lives today. Learn more about how the Cystic Fibrosis Foundation and Vertex Pharmaceuticals are working on treatments to aid those living with CF, and support Great Strides on their quest to ...
New Lease on Life
June 16, 2020 08:00 - 34 minutes - 47.7 MBDr. Guy Leclerc plays the role of both a researcher and a clinician, changing lives with his work on medical devices. Learn how his work directly improved the quality of life for a very special patient. Learn more about Isabelle’s story, and support what drives Dr. Leclerc by donating to the CHUM foundation. ACKNOWLEDGMENTS Hosted by: Gina Mullane Produced and Edited by: Meaghan Root and Ryan Stevenson Sound and Music by: David Coscia and Ryan Stevenson Special thanks to: Dr. Guy ...
Leading the Way
May 15, 2020 22:30 - 30 minutes - 41.7 MBJake Glanville, founding partner and CEO of Distributed Bio, has been featured in the Netflix series "Pandemic." Now, he and his team are on the front lines of the fight against COVID-19, working tirelessly to find a cure. Learn how his roots in Guatemala have shaped his beliefs on healthcare, how a family business has developed his skills as a leader, and how it all came together in his leadership of a talented, accomplished team of scientists. Read more about antibody discovery ...
Uncommon Bond
April 21, 2020 08:00 - 46 minutes - 37.2 MBTwins share many unique bonds, and for Jaci and Alex, fighting the same rare disease is one of them. Hear this emotional tale through the perspective of their mom, Lori, and their uncle, Mike, about how they have battled their illness, knowing the risks, and helped to develop a new treatment for this rare form of ALS. To learn more about Jaci’s story, please visit Cowgirl Up for Jaci: Roping in a CURE for ALS. For more information about ALS, please visit Project ALS. ACKNOWLEDGME...
Humble Beginnings
March 17, 2020 08:00 - 36 minutes - 29.2 MBCollege can take you many places. In the case of two neuroscience students, they didn’t know where their journey would take them. Their perseverance and fighting spirit built a company that aims to help those battling neurodegenerative diseases. See what Amylyx is working on.
An Angel’s Determination
February 15, 2020 14:30 - 52 minutes - 72.6 MBThere are certain moments when life takes on a whole new meaning. For Allyson Berent, her daughter’s diagnosis with a rare genetic disorder gave her a purpose – to embark on the quest for a cure. Hear her remarkable journey from a veterinarian to the COO of GeneTx Biotherapeutics, and how partnering with Ultragenyx pharmaceutical fuels her determination to cure Angelman Syndrome. Learn more about FAST (Foundation for Angelman Syndrome Therapeutics).
Turning Point
January 21, 2020 09:00 - 28 minutes - 26.6 MBWhat we experience can leave a lasting impact on our lives. In Carina’s case, her father’s diagnosis changed her career forever. Hear the emotional story of her ongoing fight to honor his memory and help others battling this rare neurodegenerative disease. Learn more about the Multiple System Atrophy Coalition
A Toxigenic Situation
December 17, 2019 08:45 - 41 minutes - 33.1 MBDonnie Patterson is not just a pharmaceutical microbiologist. He’s also a victim of toxigenic mold, a growing problem in South Carolina schools. Hear how his story exposed an issue that led to his ongoing fight for tougher mold testing regulations. Visit the Global Indoor Health Network website for more information on toxic mold.
The Pathway
November 19, 2019 08:15 - 48 minutes - 55.7 MBMila’s groundbreaking treatment, the first created and approved for a single patient, has given hope to thousands of rare-disease patients around the world. Hear Julia Vitarello, Mila’s Mom, and Dr. Timothy Yu discuss their plans to help other children with rare disease. Watch the documentary and learn more about Mila’s story at: www.criver.com/everystep In partnership with Mila’s Miracle Foundation, we are on a mission to bring this new treatment path to children fighting rare di...
Being the First
October 22, 2019 07:15 - 43 minutes - 35.3 MBMila is a young girl fighting Batten Disease, a rare, fatal disease with no cure. Her Mom, Julia Vitarello sits down with Gina to tell the story of Mila’s diagnosis and her incredible journey since; from diagnosis to Mila’s experimental genetic treatment, created just for her. Watch the documentary and learn more about Mila’s story at www.criver.com/everystep. Hosted by: Gina Mullane and Chris Garcia Produced by: Meaghan Root, Ryan Stevenson Sound and Music by: Ryan Stevenson Spec...
This is Vital Science™
September 26, 2019 21:00 - 1 minute - 1.12 MBMeet our hosts Gina Mullane and Chris Garcia as they introduce Vital Science™, a brand new podcast that shares the personal stories of those impacted by life science. Subscribe so you don't miss us, starting October 2019. ACKNOWLEDGMENTS Hosted by: Gina Mullane and Chris Garcia Produced by: Meaghan Root and Ryan Stevenson Sound and Music by: Ryan Stevenson