Jeffrey Nix MD and Soroush Rais-Bahrami, MD highlight focal therapy concepts and options for prostate cancer. With regard to functional preservation, as focal therapy may preserve functionality for some well-selected patients at the cost of a higher risk of progression before definitive treatment can be performed, they speak about how for many intermediate-risk patients for whom the risk of progression with active surveillance is unacceptably high, but for whom quality of life with whole-gland treatment would be too low, focal therapy offers a possible solution. Lastly, they share novel focal therapy modalities that are being investigated at UAB Medicine.