Thorax Podcast
73 episodes - English - Latest episode: about 2 months ago - ★★★★ - 1 ratingThorax, the official journal of the British Thoracic Society, publishes influential clinical and experimental research in respiratory medicine, paediatrics, immunology, pharmacology, pathology, and surgery. The focus is on work that advances scientific understanding and impacts clinical practice.
http://thorax.bmj.com/
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Episodes
Journal club: The effects of closing schools during an influenza pandemic
February 13, 2013 16:57 - 8 minutes - 11.9 MBClosing schools to restrict the spread of influenza during a pandemic is an idea oftern floated, but what effect does it actually have? Thorax’s Journal Club editor Jennifer Quint asks David Earn, professor of mathematics, McMaster University, what his work on the 2009 H1N1 outbreak in Alberta, Canada reveals. See also: http://annals.org/article.aspx?articleid=1033342
Journal club: Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis
February 13, 2013 16:55 - 8 minutes - 11.7 MBA combination of prednisone, azathioprine, and N-acetylcysteine has been widely used as a treatment for idiopathic pulmonary fibrosis, however the safety and efficacy of this three-drug regimen is unknown. Jennifer Quint, Thorax’s Journal Club editor, talks to Fernando Martinez, Professor, Department of Internal Medicine, University of Michigan, Ann Arbor, about the controversy surrounding the question, and what his paper on it reveals. See also: http://www.nejm.org/doi/full/10.1056/NEJMoa...
Journal Club: Predicting survival in resected non-small-cell lung cancer
February 13, 2013 16:54 - 8 minutes - 11.8 MBJennifer Quint, Thorax’s Journal Club editor, talks to David Jablons, University of California San Francisco, and consultant for Life Technologies, about his assay to predict survival in resected non-squamous, non-small-cell lung cancer. See also: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2961941-7/abstract
Journal Club: Outcomes after thoracoscopic versus open lobectomy
February 13, 2013 16:52 - 8 minutes - 11.1 MBJennifer Quint, Thorax’s Journal Club editor, talks to Subroto Paul, Division of Thorasic Surgery at New York Presbrytarian Hospital System, about his study comparing short-term postoperative outcomes following open and thoracoscopic lobectomy. See also: http://www.ncbi.nlm.nih.gov/pubmed/22826474 http://thorax.bmj.com/content/early/2012/08/23/thoraxjnl-2012-202521.full
Journal Club: Lung protective mechanical ventilation
February 13, 2013 16:49 - 9 minutes - 12.7 MBJennifer Quint (Thorax’s journal club editor) talks to Dale Needham (associate professor of medicine, Johns Hopkins University School of Medicine) about his paper recently published in the BMJ: See also: http://www.bmj.com/content/344/bmj.e2124
Non-eosinophilic asthma
February 13, 2013 16:47 - 23 minutes - 9.35 MBIan Pavord (Thorax editor) talks to Peter Gibson (professor of respiratory medicine, John Hunter Hospital, New South Wales, Australia) about non-eosinophilic asthma, particularly neutrophilic asthma. They discuss the stability of the different inflammatory phenotypes, tools to recognise non-eosinophilic asthma, whether these patients benefit from inhaled steroids, and Professor Gibson’s paper investigating the relationship between H influenzae respiratory infection and neutrophilic asthma. ...
Journal club: Bioartificial scaffolds to replace airway defects
February 13, 2013 16:46 - 6 minutes - 2.6 MBJennifer Quint (Thorax’s journal club editor) talks to Paolo Macchiarini (professor in the Advanced Center for Translational Regenerative Medicine, Karolinska Institutet, Stockholm) about using bioartificial scaffolds to replace complex airway defects. Professor Macchiarini was part of a team who replaced the airway of a tracheal cancer patient with a tailor-made bioartificial scaffold. Their paper was recently published in the Lancet: http://www.thelancet.com/journals/lancet/article/PIIS0...
Journal Club: CPAP for the metabolic syndrome in patients with obstructive sleep apnea
February 13, 2013 16:44 - 8 minutes - 11.2 MBObstructive sleep apnea is associated with an increased prevalence of the metabolic syndrome and its components. Professor SK Sharma (head of the Department of Medicine, All India Institute of Medical Sciences) has investigated whether treatment of obstructive sleep apnea syndrome with continuous positive airway pressure (CPAP) would modify these outcomes. Jennifer Quint (Thorax’s Journal Club editor) speaks to him about his results recently published in The New England Journal of Medicine. ...
Journal club: Detecting COPD through lung cancer screening
February 13, 2013 16:43 - 3 minutes - 4.69 MBJennifer Quint (Thorax’s Journal Club editor) talks to Onno Mets (Department of Radiology, University Medical Centre Utrecht) about his paper recently published in JAMA: http://jama.jamanetwork.com/article.aspx?articleid=1104554
Journal club: Chronic disease management for tobacco dependence
February 13, 2013 16:41 - 6 minutes - 9.5 MBJennifer Quint (Thorax’s journal club editor) talks to Ann Joseph (Wexler Professor of Medicine, University of Minnesota) about whether treating tobacco dependence as a chronic condition results in better short and long term quit rates.
Journal club: Lung regeneration after influenza and the role of stem cells
February 13, 2013 16:40 - 13 minutes - 12.4 MBJennifer Quint (Thorax’s Journal Club editor) talks to Frank McKeon (Genome Institute of Singapore, Harvard Medical School) about his work into the extent of lung regeneration following catastrophic damage and the potential role of adult stem cells. Dr McKeon’s latest paper, published in Cell, examines airway regeneration in mice after H1N1 influenza infection. See also: http://www.cell.com/abstract/S0092-8674%2811%2901173-1
Journal club: Cytisine for smoking cessation
February 13, 2013 16:39 - 10 minutes - 10.1 MBMany treatments available for smoking cessation are unaffordable for the majority of smokers, however cytisine is one exception. Jennifer Quint (Thorax’s journal club editor) talks to Robert West (Department of Epidemiology and Public Health, University College London) about the mechanism of the drug and his research into its efficacy and cost-effectiveness. Professor West’s trial was recently published in the New England Journal of Medicine. See also: http://www.nejm.org/doi/full/10.1056/...
Journal club: Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis
February 13, 2013 16:37 - 6 minutes - 6.14 MBOnly one treatment is licensed for idiopathic pulmonary fibrosis and this only in Europe. Luca Richeldi (Center for Rare Lung Diseases, University of Modena, Italy) describes his phase 2 trial of a tyrosine kinase inhibitor to see if it could be safely and effectively used in patients with the disease. Dr Richeldi’s research was published in the New England Journal of Medicine. See also: http://www.nejm.org/doi/full/10.1056/NEJMoa1103690
Journal club: Airway bypass for emphysema
February 13, 2013 16:35 - 5 minutes - 4.92 MBJennifer Quint (Thorax’s journal club editor) talks to Pallav Shah (a respiratory physician at the Royal Brompton Hospital, UK) about his trial of airway bypass for patients with severe emphysema, recently published in the Lancet. Dr Shah explains the procedure and how effective it was. See also: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2961050-7/abstract
Journal club: Lebrikizumab treatment in adults with asthma
February 13, 2013 16:34 - 8 minutes - 8 MBJennifer Quint (Thorax’s journal club editor) talks to Dr John Matthews (Genentech) about his New England Journal of Medicine published study into whether lebrikizumab, an interleukin-13 monoclonal antibody, can improve asthma control. Dr Matthews explains the proposed mechanism behind the treatment and how they found it increased FEV1 in adults for whom inhaled glucocorticoids didn’t control their asthma - especially in those with high periostin levels. Dr Matthews was involved in the Mil...
Journal club: Azithromycin and increased mycobacterial infections in cystic fibrosis patients
February 13, 2013 16:31 - 8 minutes - 2.91 MBIn this inaugural Thorax journal club podcast, Jennifer Quint (Thorax’s journal club editor) talks to Dr Andres Floto (University of Cambridge) about how he’s confirmed long-term use of azithromycin in cystic fibrosis patients can lead to increased nontuberculous mycobacteria infections. Having recently had this work published in the Journal of Clinical Investigations, Dr Floto also explains the underlying machanism he identified for this. See also: http://www.jci.org/articles/view/46095
Smoking in the young
February 13, 2013 16:29 - 15 minutes - 10.7 MBWe were delighted to speak to Professor John Britton about the research published in the October issue of Thorax, by his and other groups, on smoking in the young. John is a chest physician, an epidemiologist and a former editor of Thorax. He is the director of the UK Centre for Tobacco Control Studies at the University of Nottingham. John has been a giant in tobacco research. He chaired the influential RCP Tobacco Advisory Group and played a major role in making the case for banning smokin...
Lung transplant rejection and proximity to a major road
February 13, 2013 16:28 - 11 minutes - 10.6 MBA paper recently published in Thorax looks at the link between bronchiolitis obliterans syndrome in lung transplant recipients and the proximity of a major road to their home. In this podcast, two of the authors of that paper, Tim Narwot and Bart M Vanaudenaerde, talk to Paul Cullen about their research. See also: http://thorax.bmj.com/content/early/2011/03/31/thx.2010.155192.abstract?
Bronchi and the bugs: what kickstarts asthma
February 13, 2013 16:22 - 16 minutes - 7.59 MBAndrew Bush, Professor of Paediatric Respirology Imperial College London, talks to Fernando Martinez, Professor of Pediatrics and Director of the Arizona Respiratory Center at University of Arizona, about recent developements in the understanding of the link between childhood asthma and infection.
August 2010
February 13, 2013 16:21 - 9 minutes - 4.46 MBEach month we aim to bring you an insight into different areas of Thorax, and explain a bit about the editorial processes and decisions that go on behind the scenes. In this podcast Dr Angshu Bhowmik talks to Thorax Editor Professor Wisia Wedzicha about her time as Thorax editor, and what steps to take to become an editor in a scientific journal.
March 2010
February 13, 2013 16:20 - 17 minutes - 16.2 MBWelcome to the Thorax podcast Each month we aim to bring you an insight into different areas of Thorax, and explain a bit about the editorial processes and decisions that go on behind the scenes. In this podcast Dr Angshu Bhowmik talks to Thorax Editor Professor Wisia Wedzicha about the articles highlighted in March’s “Airwaves”. They also discuss the importance of trial registration.
January 2010
February 13, 2013 16:17 - 9 minutes - 9.06 MBWelcome to the Thorax podcast Each month we aim to bring you an insight into different areas of Thorax, and explain a bit about the editorial processes and decisions that go on behind the scenes. In this podcast Dr Angshu Bhowmik talks to Thorax Editor Professor Wisia Wedzicha about the articles highlighted in January’s “Airwaves”. They also give some tips on writing a good paper.
December 2009
February 13, 2013 16:13 - 11 minutes - 10.3 MBWelcome to the first Thorax podcast Each month we aim to bring you an insight into different areas of Thorax, and explain a bit about the editorial processes and decisions that go on behind the scenes. In this first podcast Dr Angshu Bhowmik talks to Thorax Editor Professor Wisia Wedzicha about the articles highlighted in December’s ‘Airwaves’