Producing challenging proteins in the golden age of protein engineering

In this episode, we roam the world of recombinant proteins and their production, discussing the challenges of their production, and recent evolutions in protein engineering that have brought the field into a golden era of innovation.

I'm joined by recombinant protein engineering expert Yuning Chen, R&D Manager at Sino Biological, who discusses the key applications of recombinant proteins, the aspects of certain products that make them difficult to produce and how these difficulties can be overcome. Yuning also reveals how the manipulation of antibodies has been essential to multiple aspects of our response to the COVID-19 pandemic.

After a review of the recent evolutions in protein engineering, from cell-free systems to automation, Yuning describes his vision for the future of the field and reveals his support for the Terminator-style uprising that he believes could revolutionize it.

ContentsThe production of recombinant proteins: 00:48-02:11The key applications of recombinant proteins: 02:11-03:27What makes some proteins difficult to produce? 03:27-04:41Overcoming these challenges: 04:40-5:40Manipulating antibodies to take part in multiple aspects of pandemic response: 05:40-08:00The most exciting applications of recombinant proteins: 08:00-09:50Developments in high throughput and automated protein engineering: 09:50-11:00Cell-free protein engineering: 11:00-12:40The benefits of cell-free systems: 12:40-13:40What is next for recombinant protein production? 13:40-16:15The dream of automation for the recombinant protein production: 16:15-18:50 

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