Antigen validation and T-cell receptor engineering for cancer immunotherapies

This episode of the Talking Techniques podcast dives into the realm of cancer immunotherapies, focusing on antigen discovery and T-cell receptor engineering for T-cell therapies. Guiding us through the field is Jim Heath, President of the Institute for Systems Biology in Seattle, where he runs the Heath Lab, investigating fundamental immunology, and infectious and chronic diseases.

Jim discusses the computational models and wet lab techniques he uses to characterize T cells, the importance of targeting a balanced immune response with immunotherapies and more in this podcast recorded at AACR 2024 (5th–10th April 2024; San Diego, CA, USA).

Introductions: 00:00-02:00

Intro to cancer vaccines and T-cell therapies: 02:00-04:00

Antigen detection and validation in T-cell therapies: 04:00-05:20

Wet lab and computational techniques for antigen detection: 05:20-09:15

The importance of a balanced immune response to cancer immunotherapies: 09:15-10:30

Technological developments in antigen detection: 10:30-13:45

Tips for best practice when conducting T-cell receptor design 13:45-15:40

What is one thing you would like to see change in the field of antigen detection and T-cell receptor engineering? 15:40-16:30

Designing the path towards a more balanced immune response from immunotherapies 16:30-19:40

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