282 – An App to Identify On-Target Gene Editing Variation

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At its core, gene editing works to break gene function by creating errors in a DNA sequence at a specific location. The process works by creating a precise cut that is repaired by the cell’s repair mechanisms, and those processes can be error prone.  Those errors are the basis of the gene’s disruption.  But in a population of cells, how do you account for and catalog all of the changes?  Kevin Bloh is a research associate and a Ph.D. student with Christiana Care / University of Delaware.  He describes computational tool that help define the variation around gene edited sites. The new tools help refine cells possibly destined for research or therapeutic applications.

DECODR software link.  www.decordr.org