Knowing the histology and embryology of the anorectal junction helps you to understand why you should band piles above the dentate line, why cancers in the region have different tissues of origin and spread to different lymph nodes. In this video podcast Susan Anderson takes you though important histological features of the large bowel and contrasts them with the different features of the anal canal. Clinical application of these features is also described Dr Susan Anderson is Associate Professor in Pathology at the University of Nottingham, UK