Ep 69: Management of Gynecologic Issues in Women With Breast Cancer

Practice Bulletin #126, Published March 2012 (Reaffirmed 2016)



1. Rapidly dividing cells - like those in the gonads - are the most susceptible to chemo, so suppressing with GnRH analogues prior to chemo may be protective against ovarian toxicity, but data is mixed.

2. BRCA mutation carriers are at increased risk for both breast and ovarian cancers, therefore prophylactic BSO is recommended at age 40 or after childbearing is complete

3. 5 years of tamoxifen use decreases the annual risk of recurrence by 40% and annual mortality risk by 35%

4. Women treated for breast cancer are at higher risk for bone fracture because chemotherapy, ovarian suppression, and, especially aromatase inhibitors all lead to bone loss and osteoporosis.

5 .HRT has a bad rap historically due to concern that it may predispose women to de novo breast cancer or recurrence, but the findings have been mixed and generally not statistically insignificant.



Show Notes



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Wine pairing: 2017 Perlita Malbec-Syrah from Bodega DiamAndes

Theme music by Evan Handyside

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