Malaria
10 episodes - English - Latest episode: over 8 years ago - ★★★★★ - 1 ratingMalaria is an endemic disease in much of the world, and is a major contributor to child and infant mortality in many countries. Our malaria podcasts describe efforts by NDM clinicians and scientists, in Oxford and around the world, to treat and prevent malaria, including vaccine development, parasitology, and improved treatment for severe malaria, with the aim to lessen the disease burden on some of the world's most vulnerable people.
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Episodes
Artemisinin Resistance
October 05, 2015 16:17 - 6 minutes - 7.36 MBArtemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem. MALARIA TREATMENT Dr Charlie Woodrow is based at MORU in Bangkok, Thailand, where he coordinates clinical and laboratory studies on resistance to artemisinins. Bringing together diverse datasets of clinical, in vitro and molecular data has helped better understand the emerging resistance, particularly in Myanmar.
Getting the dose right
July 28, 2015 15:35 - 7 minutes - 8.02 MBToo high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance. Professor Joel Tarning is Head of Clinical Pharmacology in our MORU Unit in Bangkok, Thailand. He's working towards drug dose-optimisation using novel pharmacometric modelling approaches. He is particularly interested in antimalarial treatments for children and pregnant women.
Artemisinin therapy for malaria by Professor Nick White
June 18, 2013 12:42 - 5 minutes - 4.97 MBProfessor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.
Can we block malaria transmission
May 07, 2013 16:27 - 7 minutes - 7.08 MBDr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle. Malaria transmission-blocking vaccines aim to induce immunity against the parasites that infect mosquitoes. Such vaccines will prevent malaria transmission on a wider scale, focusing on the community rather than the individual. Dr Sumi Biswas is working on the development of transmission-blocking vaccines to prevent the spread of malaria.
Progress in Malaria Vaccine Research
September 11, 2012 11:55 - 6 minutes - 12.2 MBDr Simon Draper tells us about his progress in malaria vaccine research. The malaria parasite is a 'master of disguise'. Whilst the development of a vaccine has proved difficult, targeting a pathway for the parasite has led to the neutralisation of all strains of Plasmodium falciparum. Dr Simon Draper's research interests include studies of vaccine-induced malaria immunity and trials of vaccine candidates. Focusing on translational medicine, his group will take their most promising vaccine ca...
Malaria vaccine for P. vivax
June 19, 2012 12:26 - 7 minutes - 8.11 MBDr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax. Plasmodium vivax, one of the four malaria parasites that affect humans, is difficult to eradicate due to its ability to lay dormant in the liver for long periods of time. This parasite is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year. Dr Arturo Reyes...
The treatment of severe malaria
February 21, 2012 16:10 - 8 minutes - 9.59 MBProfessor Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Current malaria therapies using artesunate aim to kill malaria parasites before they mature. Such medications have high success rates but need to be developed further. Based in Bangkok, Thailand, Professor Arjen Dondorp works on the pathophysiology and treatments of severe malaria, antimalarial drug resistance, and improvements in intensive care practice within developing countries.
Tropical Medicine in Kenya
July 19, 2011 10:49 - 3 minutes - 4.6 MBProfessor Kevin Marsh tells us about his research on Tropical Medicine in Kenya. Professor Kevin Marsh has a broad research interest in child health in the tropics, with a particular focus on the immune epidemiology of malaria. Malaria remains a major world health problem, particularly among children in Africa. Based in Kenya, Professor Marsh is working on preventing and curing malaria in Africa. Professor Marsh is director of the KEMRI Wellcome Programme in Kenya; he also coordinates the mal...
Malaria and Global Health
November 02, 2010 10:31 - 7 minutes - 7.13 MBDr Climent Casals-Pascual tells us how new tools can help us diagnose and manage malaria more effectively. In tropical countries, poor diagnosis of malaria often results in sub-optimal treatments. Clinical symptoms of severe malaria are similar to those of other diseases like pneumonia and meningitis. Dr Climent Casals-Pascual is researching the diagnosis and clinical management of severe malaria in tropical populations. Integrating proteomic, genomic and clinical data will help us explain di...
Malaria Vaccines
October 18, 2010 15:58 - 5 minutes - 5.05 MBProfessor Adrian Hill talks about recent developments of vaccines against malaria. Around half of the world's population is at risk of contracting malaria. After studying malaria susceptibility in African children for many years, Professor Adrian Hill is now developing a vaccine against malaria by inducing cellular immune responses (T lymphocytes), instead of taking the more common research approach of stimulating antibodies. Prophylactic vaccines developed in Oxford are now showing great pro...