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Nouns ending in 'o' are generally masculine:

amico = friend (male)

libro = book

Nouns ending in 'a' are generally feminine:

amica = friend (female)

casa = house

Nouns ending in 'e' can be both and simply must be memorized:

ristorante (m) = restaurant

pane (m) = bread

classe (f) = class

notte (f) = night

Words ending with a consonant are usually foreign words, and are usually masculine:

bar, autobus, film, sport