David Fäh explains whether large doses of vitamin D supplementation in a monthly or annual dose are a good idea to prevent the risk of falls and fractures in the elderly. 

Daily supplementation versus irregular supplementation
The problem with higher doses of vitamin D
Can we get vitamin D through windows ?
Best stategies for the elderly to promote bone health

Vitamin D supplementation has not yet been shown to offer clinically relevant health benefits in terms of inflammation.  On the contrary, studies with harder endpoints (e.g. fracture or mortality) have not shown benefits. Moreover, vitamin D supplementation carries risks. Very high doses or administration at intervals, e.g. as a monthly or annual bolus, may actually increase the risk of falls, fractures and possibly other adverse effects. Supplementation in people with values in the normal range is superfluous, and could even do harm in extreme cases.


References:


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689821/


https://www.sciencedirect.com/science/article/pii/S2213858718302651?via%3Dihub


https://pubmed.ncbi.nlm.nih.gov/20460620/

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