JNNP Podcast
185 episodes - English - Latest episode: 27 days ago - ★★★★★ - 7 ratingsJNNP’s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson’s disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage and neuropsychiatry), but with a keen interest in the Gordian knots that present themselves in the field, such as ALS.
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Episodes
BNPA 2013: Stress and war, and the limits of neuropsychiatry
February 18, 2013 11:29 - 9 minutes - 13.3 MBNeil Greenberg, academic psychiatrist, Kings College London, who’s served in the armed forces for more than 20 years, argued in his JNNP-sponsored keynote at BNPA that we understand many of the issues in military mental health, and that the neuropsychiatric element is relatively small. Alan Carson, JNNP associate editor, talks to him about the impact of being in the military on mental health beyond PTSD. This podcast was recorded at the British NeuroPsychiatry Association’s 2013 AGM. For mo...
BNPA 2013: Childhood stress and risk for later mental disorder
February 18, 2013 11:28 - 10 minutes - 14.2 MBDavid Skuse, professor in the Behavioural Sciences Unit, Institute of Child Health, talks to Jeremy Hall, professor of psychiatry and neuroscience at the University of Cardiff, about his work investigating the link between childhood stress and borderline personality disorder. This podcast was recorded at the British NeuroPsychiatry Association’s 2013 AGM. For more information on the association and next year’s meeting, see bnpa.org.uk.
BNPA 2013: Inflammation and mental illness
February 18, 2013 11:25 - 7 minutes - 10.5 MBAlan Carson, JNNP associate editor, talks to Neil Harrison, consultant neuropsychiatrist and head of psychoneuroimmunology, Brighton and Sussex Medical School, about what we currently know about inflammation in mental disorders. Dr Harrison also discusses the potential of anti-inflammatories to treat depression. This podcast was recorded at the British NeuroPsychiatry Association’s 2013 AGM. For more information on the association and next year’s meeting, see bnpa.org.uk.
BNPA 2013: Posttraumatic stress disorder and the brain
February 18, 2013 11:24 - 9 minutes - 13.3 MBDavid Skuse, professor in the Behavioural Sciences Unit, Institute of Child Health, asks Chris Brewin, professor of clinical psychology, UCL Faculty of Brain Sciences, about the different forms of PTSD experience, the cognitive processes involved, and how understanding these could inform psychological therapies for the condition. This podcast was recorded at the British NeuroPsychiatry Association’s 2013 AGM. For more information on the association and next year’s meeting, see bnpa.org.uk.
BNPA 2013: Equipped to survive, how comprehensive response to threat enables optimal behaviour
February 18, 2013 11:16 - 7 minutes - 10.7 MBThe human response to threat requires comprehensive change in the network properties of the brain, with the whole organ affected. Alan Carson, JNNP associate editor, asks Guillén Fernández, director of the Donders Center for Neuroscience, Radboud University Nijmegen Medical Center, about his work investigating the effects of stressors on brain structure and function. This podcast was recorded at the British NeuroPsychiatry Association’s 2013 AGM. For more information on the association and ...
Discovering Emery-Dreifuss muscular dystrophy, and flavour identification in FTLD
February 15, 2013 17:27 - 22 minutes - 30.5 MBIn the last JNNP podcast of 2012, we look at what jelly beans and the Andalucian mountains have done for neurology and psychiatry. Alan Emery, emeritus professor, Green Temple College, University of Oxford, describes studying the family that led him to delineate Emery-Dreifuss muscular dystrophy. And Jason Warren and Rohani Omar, UCL Institute of Neurology, talk about what their study into flavour identification in frontotemporal lobar degeneration reveals. See also: Impact commentary: U...
The future of epilepsy research, assessing hemianopia, measuring sensory nerve action potentials
February 15, 2013 17:25 - 31 minutes - 43.6 MBThis month, Mark Richardson, professor of epilepsy, Kings College London, relates his vision for the future of epilepsy research (1.07). Alexander Leff, consultant neurologist, Institute of Cognitive Neuroscience, University College London, discusses his online tool for diagnosing and providing treatment for hemianopia, the visual impairment which can follow stroke or brain injury (14.07). And measuring sensory nerve conduction. Tom Sears, emeritus professor of neurophysiology, King’s Coll...
The Scheltens scale, disability after head injury, and cannabis for multiple sclerosis
February 15, 2013 17:19 - 23 minutes - 31.7 MBThis month, we explore the latest research on treating multiple sclerosis with cannabis extract. Editor Matthew Kiernan speaks to John Zajicek, professor of Clinical Neuroscience, Peninsula College of Medicine and Dentistry, UK. (0.54) Received wisdom is that if you are disabled shortly after a head injury, you are not going to see this improve. However Tom McMillan, professor of Clinical Neuropsychology, University of Glasgow, explains how he has shown long term outcomes are actually dynam...
Early days of the Queen Square brain bank; rating dopaminergic replacement therapy response
February 15, 2013 17:17 - 31 minutes - 43.5 MBThe Queen Square brain bank was set up by Andrew Lees, and whilst there he co-authored two of JNNP’s most highly cited papers – one on the importance of Lewy bodies in Parkinson’s, and the other on the accuracy of clinical diagnosis of the disease. Now director of the Reta Lila Weston Institute of Neurological studies, University College London, he discusses the changing relationship between pathologists and clinicians, and the progress he’s seen in diagnosis. Assessing response to dopamine...
Oliver Sacks’s functional paralysis; progressive multifocal leukoencephalopathy
February 15, 2013 17:14 - 20 minutes - 19.1 MBIn 1974 Oliver Sacks was hiking through a remote part of Norway when he suffered a nasty injury to one leg. Although he managed to get to help and was successfully operated on, he struggled to relearn to walk and felt alienated from the limb. Jon Stone (consultant neurologist in the Department of Clinical Neurosciences, University of Edinburgh) explains why from Sacks’s writing he thinks this was a case of functional paralysis, and why the account is so valuable. And progressive multifocal ...
Recovery after stroke; malingering after concussion
February 15, 2013 17:12 - 27 minutes - 11 MBDerick Wade (professor and consultant in neurological rehabilitation at the Oxford Centre for Enablement) and Nick Ward (JNNP associate editor and reader in clinical neurology at UCL) discuss the past, present and future of measuring and predicting recovery after stroke. And poor effort, exaggeration and malingering can be used to explain why individuals post-concussion report persistent symptoms inconsistent with the severity of their injury. However Jonathan Silver (clinical professor of ...
The future of glioblastoma therapy
February 15, 2013 17:10 - 13 minutes - 5.55 MBDespite current standard care for glioblastoma being aggressive, mean survival is around 14 months. Clark Chen (director of Clinical Neuro-oncology, Beth Israel Deaconess Medical Center, Boston) argues we need a better understanding of the therapeutic concepts that have evolved over the past three decades to develop treatment, and in a JNNP article this month he lays out seven of these key ideas. Peter Warnke (JNNP associate editor) discusses them with him. See also: Key concepts in gliobl...
Neurological symptoms from autoimmune syndromes; movement disorders and OCD; counting strokes
February 15, 2013 17:08 - 34 minutes - 13.8 MBThis month, editor Matthew Kiernan discusses new guidelines for recognising central nervous system neuronal surface antibody associated symptoms with Angela Vincent (emeritus professor of neuroimmunology at Oxford University). Danielle Cath (psychiatrist at Altrecht Academic Anxiety Outpatients Clinics, Utrecht University) explains what her review of the relationship between obsessive compulsive disorder and movement disorders reveals. And Charles Warlow (emeritus professor of medical neur...
Idiopathic intracranial hypertension; discovering the neurological effects of critical illness
February 15, 2013 17:05 - 23 minutes - 32 MBThis month Beau Bruce (assistant professor of ophthalmology and neurology, Emory University School of Medicine, Atlanta) discusses what we do and don’t know about idiopathic intracranial hypertension, and offers some clinical advice on the syndrome for neurologists. And Charles Bolton (professor in the Department of Medicine, Queen’s University, Ontario, Canada) talks us through his investigations in the 1980s which discovered critical illness could cause neurological problems. See also: ...
Diagnostic criteria for CBS; tractography in ALS fifty years ago; better tests for bvFTD
February 15, 2013 17:03 - 31 minutes - 42.9 MBIn April’s podcast, we put a spotlight on amyotrophic lateral sclerosis and frontotemporal dementia. Maxime Bertoux, a neuropsychologist at Paris-Sorbonne University, discusses the problem of misdiagnosis of the behavioural variant of FTD, and how he’s shown the Social Cognition and Emotional Assessment is a more powerful tool than others in use (20.50). And Martin Turner, consultant neurologist at Oxford University Nuffield Department of Clinical Neuroscience, talks about early tractograp...
Surrogate outcomes; CAA and IH; Angela Vincent looks back
February 15, 2013 16:59 - 26 minutes - 23.9 MBThis issue we look at short-term outcomes used to assess multiple sclerosis treatments, and their power to predict long-term disability, with Douglas Goodin (professor of clinical neurology, University of California, San Francisco). We return to the association between cerebral amyloid angiopathy and intracerebral haemorrhage, as Neshika Samarasekera (Division of Clinical Neurosciences, University of Edinburgh) talks us through her research examining the link. And Angela Vincent (emeritus ...
Cerebral amyloid angiopathy; lifestyle and mortality after stroke; motor output patterns
February 15, 2013 16:55 - 22 minutes - 20.7 MBThis month, cerebral amyloid angiopathy. David Werring (Stroke Research Group, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery) discusses the importance of detecting it, especially as he feels it is under-recognised by physicians. What impact does a healthy lifestyle have on mortality following stroke? Amytis Towfighi (Division of Stroke and Critical Care, Department of Neurology, University of Southern California) tells us what her research found. And l...
The early days of chronic fatigue syndrome research; Clues to functional weakness mechanism
February 15, 2013 16:52 - 29 minutes - 20.4 MBIn this first podcast of 2012 editor Matthew Kiernan talks about JNNP’s new impact commentaries - a series which will explore influential papers from the journal. A paper by Simon Wessely (King’s College London) comparing postviral fatigue with that of neuromuscular and affective disorders is the first covered, and he and Matthew discuss this seminal research. Also, Jon Stone (University of Edinburgh) explains what his investigation into the nature of functional weakness onset indicates abo...
Diagnosing delirium
February 15, 2013 16:49 - 12 minutes - 4.48 MBThis month we discuss the issue of diagnosing delirium in older hospital patients. Despite being linked to a range of poor outcomes, the syndrome is often missed and evidence on its measurement is sparse. Professor Alasdair MacLullich tells us how a device he’s designed with colleagues at the University of Edinburgh, which tests for delirium’s attentional deficits, can benefit clinicians and researchers. See also: Detecting deficits of sustained visual attention in delirium http://tinyurl...
Diagnosing conversion disorder; exercise to prevent falls in Parkinson’s patients
February 15, 2013 16:46 - 21 minutes - 7.42 MBIn this edition Richard Kanaan (Institute of Psychiatry, King’s College London) talks about his work on conversion disorder, and gives his advice for neurologists and psychiatrists on making this tricky diagnosis. And Vicki Goodwin (Peninsula College of Medicine and Dentistry, University of Exeter) discusses her trial on whether an exercise intervention could prevent falls in those with Parkinson’s disease. See also: Conversion disorder: a problematic diagnosis http://tinyurl.com/agrtdxs ...
The natural history of Parkinson’s; the latest on MS and latitude
January 29, 2013 17:28 - 19 minutes - 17.5 MBCurrent treatments for Parkinson’s ameliorate the core, motor symptoms. However as we look for therapies to modify the underlying course of the disease there’s a need to better understand its development. Jonathan Evans, from the Cambridge Centre for Brain Repair, University of Cambridge, UK, explains what his work has revealed, and how it can progress treatment. And the latest evidence in the debate on whether multiple sclerosis prevalence increases with latitude. Steve Simpson Jnr, Menzie...
Athleticism and ALS; understanding peripherally induced movement disorders
January 29, 2013 17:20 - 19 minutes - 17.5 MBMovement disorders following head trauma are well recognised, but we know much less about those occuring after a peripheral injury. Diana van Rooijen, Leiden Medical Center, the Netherlands, tells us what her review on this group of conditions reveals (0.58). Clinicians are used to seeing ALS patients who are or have been athletic. So is there a link, and if so, could exercise have a direct effect on the condition? Dr Martin Turner, John Radcliffe University Hospital, Oxford, talks us throu...
Thrombolysis for elderly stroke patients; disability with organically-unexplained symptoms
January 29, 2013 17:17 - 20 minutes - 9.4 MBIntravenous thrombolysis is the only curative treatment for acute ischaemic stroke, but is only licensed for patients up to 80 years old. Dr Paul Guyler, Southend Hospital NHS Trust, UK, discusses the evidence for outcomes in those over this limit, and whether or not doctors should treat off-licence. Also in this July edition, Dr Alan Carson, Western General Hospital, Edinburgh, UK, on his research into disability, distress and employment in neurology outpatients who’s symptoms can’t be ex...
Finger length ratio and ALS; psychotherapy for dizziness
January 29, 2013 17:11 - 10 minutes - 10 MBDizziness can significantly complicate peoples’ lives, especially if it does not have a satisfactory medical explanation. We talk to Dr Gabriele Schmid of the Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Germany, about how psychotherapy might be beneficial for these patients. Also in this month’s podcast, Professor Ammar Al-Chalabi of King’s College London discusses the link between prenatal testosterone levels and ALS. See also: Psychotherapy in...
Frontotemporal dementia reviewed; temporal orientation and dementia
January 29, 2013 17:07 - 18 minutes - 17 MBRecent clinical, neuropsychological, imaging, genetic and pathological developments have changed our understanding of frontotemporal dementia, its classification and criteria. Dr Jonathan Rohrer, Dementia Research Centre, UCL Institute of Neurology, London, talks about these advances and future research directions. Also in this edition, Dr Shaun O’Keeffe, Merlin Park University Hospital, Dublin, explains how simple questions about time are, and should be, used to assess dementia and deliriu...
Dementia and word knowledge; DBS for Parkinson’s
January 29, 2013 16:53 - 17 minutes - 16.4 MBThis month Robert Wilson, Rush University Medical Center, Chicago, USA, on how dementia affects our knowledge of words, and the neuropathology which underlies this. Also, the use of deep brain stimulation to treat Parkinson’s disease. Tom Foltynie describes the image guided, rather than microelectrode guided, technique used at the National Hospital of Neurology and Neurosurgery, London, UK, and the success they’ve had. See also: MRI-guided STN DBS in Parkinson’s disease without microelect...
Genes, vitamin D and MS; hysteria and hypnosis
January 29, 2013 16:48 - 17 minutes - 15.8 MBIt’s been known for years that the prevalence of MS increases the further you go from the equator, but not why. Roisin Lonergan, from St Vincent’s University Hospital, Dublin, Ireland, describes her investigations into a genetic factor and vitamin D levels, and if they can help explain this. Also Quinton Deeley, from the Institute of Psychiatry at London’s King’s College, UK, talks about hysteria and hypnosis, and why they could stem from similar brain processes. See also Multiple scleros...
Eye movements in motor neurone disease; work and multiple sclerosis
January 29, 2013 15:02 - 15 minutes - 14.6 MBThis month Harriet Vickers (BMJ’s multimedia intern), talks to Solveig Glad about how long patients with benign multiple sclerosis stay in work, and what could help them hold down jobs. Also Colette Donaghy explains how examining eye movements in amyotrophic lateral sclerosis could help with diagnosis, and tell us more about the pathophysiology of the disease. See also: How long can you keep working with benign multiple sclerosis? http://tinyurl.com/bxjogdo Eye movements in amyotrophic l...
October 2010
January 29, 2013 14:57 - 15 minutes - 10.8 MBIn this month’s podcast Dr Amal Al Sayegh tells us about psychological therapies for treatment of post-concussion syndrome, and Dr Serena Hung describes patient’s perceptions of dyskinesia in Parkinson’s disease. See also: Psychological approaches to treatment of postconcussion syndrome: a systematic review http://tinyurl.com/bgcfkcl Patient perception of dyskinesia in Parkinson’s disease http://tinyurl.com/bcqeav3
Predicting adjustment to an ALS diagnosis
January 29, 2013 14:53 - 15 minutes - 10.8 MBTamara Matuz discusses her research looking for predictors for how well patients adjust to a diagnosis of ALS in southern Germany.
Microbleeds and abuse in dementia
January 29, 2013 14:51 - 14 minutes - 9.74 MBIn this month’s podcast David Werring from University College London talks about his research into the link between brain microbleeds and intercerebral haemmorhage. Claudia Cooper explains her research looking at abusive behaviour by dementia patients towards their carers. See also: Abusive behaviour experienced by family carers from people with dementia http://tinyurl.com/bjw6n2e Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage http://tinyur...
Migrane co-morbidities
January 29, 2013 14:48 - 14 minutes - 9.74 MBIn this month’s podcast Dawn Buse from the Montefiore Headache Center, New York, talks about her research into co-morbidities in chronic migrane sufferers. See also: Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers http://tinyurl.com/b3x44vm
The SCAN rule
January 29, 2013 14:43 - 11 minutes - 10.1 MBMatthew Kiernan (editor of JNNP) interviews Caroline Lovelock about her paper: The SCAN rule: a clinical rule to reduce CT misdiagnosis of intracerebral haemorrhage in minor stroke. This paper was the editor’s choice in the March edition of JNNP.
Epilepsy and driving; Self awareness in dementia
January 29, 2013 14:16 - 18 minutes - 16.8 MBIn this second podcast Professor Matthew Kiernan talks to Dr Rhys Thomas about the law regarding sleep-related epilepsy and driving - this month’s editor’s choice paper. Also Duncan Jarvies talks to Dr Howard Rosen about his research into self awareness in dementia patients - this month’s patient’s choice paper. For more information please see: Awake seizures after pure sleep-related epilepsy: a systematic review and implications for driving law http://tinyurl.com/a6jfzcr Standardised me...
Pregnancy and MS
January 29, 2013 13:51 - 13 minutes - 12.8 MBWe are delighted to offer you the inaugural podcast from JNNP. Recorded at BMA House London, our broadcast begins with a future vision for the journal from incoming Editor, Professor Matthew Kiernan based in Sydney. There then follows a discussion with Dr Marie D’hooghe from the National Multiple Sclerosis Centre in Belgium. Marie and Matthew discuss the long-term effects of childbirth in patients diagnosed with multiple sclerosis and uncover some interesting insights. They chat about: ...