Debate of the Decade: RCTs in the Era of Precision Oncology

How do you design clinical trials in the era of precision oncology? Are prospective randomized controlled trials necessary anymore? Drs. Ray Kurzrock, Vivek Subbiah, and Christopher Booth drop the gloves and debate these questions - beginning with the definition of “precision oncology,” what phase the trials should be when initially designing, and whether accelerated approval and surrogate endpoints are truly helping patients in the precision oncology era. The group also analyzes specific examples of approved drugs and whether randomized controlled trials were and would have been good ideas prior to approval.

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