Efforts to understand and address health effects of climate change are on the rise in the U.S., from the most recent National Climate Assessment to state and local assessments. While these reports enrich our understanding of which types of climate change-related health effects are more likely to affect particular geographic regions and populations, there is little understanding of how residents rank their own vulnerability to health effects of climate change, and the drivers of these responses. This presentation provides findings from a national, mixed-methods study to understand how vulnerable and affected residents perceive and respond to health impacts linked to climate change.