First-Person Science
35 episodes - English - Latest episode: over 3 years ago -Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your fact checking ability? We've got you covered. Journal club video podcast giving scientists a platform to control the scientific narrative & dispel the misinformation surrounding their science.
Reviewing Neuroscience research papers ft perspectives and narratives from the author(s) themselves.
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Episodes
MDMA & Psilocybin Improve PTSD & Depression Via Similar Brain Mechanisms? Psychedelic Effect Needed? || NeuroBeer Clips
August 04, 2020 15:10 - 12 minutes - 11.1 MB#neuroscience #psilocybin #MDMA #depression #psychedelicmedicine From NeuroBeer #4 - streamed live June 15, 2020. Full conversation: https://youtu.be/yhxyuBLiLs8 Do you need to have a psychedelic trip to experience the beneficial therapeutic actions of psychedelics? How long does it take for psychedelic drugs like MDMA or magic mushrooms (psilocybin) to have therapeutic effects for depression or ptsd treatment? How long do these antidepressant actions of MDMA & psilocybin last? And How d...
Using Old Drugs To Treat COVID-19? Protein Interaction Map Targets Sigma Receptors | FPS#14
August 04, 2020 13:30 - 50 minutes - 46.3 MBMany medications are being tested to treat COVID-19, including brand new drugs designed specifically for COVID-19, such as vaccines, and others. But what if we already have the right tools to tackle covid? By understanding which human proteins the virus uses to enter our human cells, we can identify existing drugs to target these protein interactions, and design better ones, too. This research project created a protein interaction map to target sigma receptors using old and new drugs alr...
Learning vs Unlearning vs Re-Learning_ Memory Engrams, Addictions, Artificial Intelligence, & PTSD || NeuroBeer Clips
August 04, 2020 08:15 - 11 minutes - 10.7 MB#reconsolidation #PTSD #neuroscience #learning #memory From NeuroBeer #4 - streamed live June 15, 2020. Full conversation: https://youtu.be/yhxyuBLiLs8 In order to remember something, you must have learned it first. When something new is learned, the brain stores that information through a series of electro-chemical connections between neurons, known as a memory 'engram'. These 'neural engrams' allow for the recall of memories by triggering the re-activation of the same brain connections...
How Psilocybin Causes Ego Death | Necessary For Therapeutic Benefits In Depression, PTSD Treatment? || NeuroBeer Clips
August 04, 2020 08:11 - 15 minutes - 14 MBFrom FPS NeuroBeer Live Stream #5 - June 22, 2020 Catch the full conversation here: https://youtu.be/yhxyuBLiLs8 The study we review in this NeuroBeer clip investigated dose-dependent distortions in the subjective experience of one’s self - often termed coloquially as 'Ego Death'. They defined ego dissolution as 'a phenomenon characterized by the reduction in the self-referential awareness that defines normal waking consciousness, ultimately disrupting self-world boundaries and increasing f...
Once An Addict, Always An Addict, But Is It True For The Brain? Dopamine in Drug Craving, Wanting vs Liking || NeuroDrugs Clip
August 04, 2020 08:06 - 8 minutes - 7.36 MB#addiction #neuroscience #memory #wanting #liking #addictedbrain From NeuroDrugs #2 - streamed live July 15, 2020. Full conversation: https://youtu.be/X8_fSqM7AZI How long does it take for the addicted brain to go back to normal, or when brain dopamine receptor levels take to return to baseline following addiction? As the saying goes, once an addict, always an addict, but is this true for the brain? We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly...
Male vs Female Learning & Memory Differences = Brain Differences? || NeuroBeer Live #11
August 04, 2020 08:03 - 2 hours - 119 MB#neuroscience #journalclub #sexdifferences It's been proposed that studying male vs female changes in brain-behaviour interactions are vital for the progression of drug development in psychiatric disorders. Indeed, these differences are abundant in neuroscience research, so much so that the NIH has mandated that all new grant proposals must measure differences between males vs females. But are these mandates really necessary? We discuss the pros vs cons of including males and females in n...
Cannabis Legalization Increases Schizophrenia Rates?? || NeuroBeer Live #10
August 04, 2020 07:59 - 1 hour - 98.8 MB#addiction #depression #ketamine #schizophrenia #legalize #cannabis #dopamine #neuroscience #NeuroBeer #live We're live tonight at 8pm to chat about recent neuroscience publications painting cannabis legalization as a gateway to increased rates of psychosis and schizophrenia. We'll also discuss whether ketamine should be treated as a final frontier of depression treatment. There is much that remains to be known about our understanding of ketamine’s antidepressant properties; and although ...
CBD for COVID19, & Elsevier Profit Margins = Origins of 'Publish or Perish'? || NeuroBeer Live #9
August 04, 2020 07:55 - 1 hour - 64.2 MB#cannabidiol #CBD #cannabis #covid19 #elsevier #publishorperish #neuroscience #NeuroBeer Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neurosci...
Cannabis Brain Changes & Debating If & Why Neuroscience is Stalled || NeuroBeer Live #8
August 04, 2020 07:52 - 1 hour - 103 MB#cannabis #brain #neuroscience #mentalhealth We're live at *8:30PM* tonight to discuss exciting new research on changes in brain connectivity following cannabis use: https://neurosciencenews.com/cannabis-brain-connectivity-16606/ and to debate why truly novel drugs for mental health disorders haven't emerged in 50+ years. Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by...
Sobering Up To Preprint Article Realities || NeuroBeer Live #7
August 04, 2020 07:49 - 1 hour - 97.1 MB#LSD #psychosis #cannabis #addiction #psychedelics #glutamate #neuroscience #serotonin We're Live to discuss and debate some of the latest developments that have damaged the reputations of science and scientists! Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EST ---------------------------------------------------------------...
Brain Opioids & Dopamine, Differences In Liking vs Wanting Addictive Drugs || NeuroDrugs Clip
August 04, 2020 07:44 - 9 minutes - 9.04 MBFrom NeuroDrugs #2 - streamed live July 15, 2020. Catch the full conversation here: https://youtu.be/X8_fSqM7AZI We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. In this clip we review the classic publication that began the 'wanting/liking' dichotomy that research...
How Psilocybin Causes Ego Death & Biology-Infused Artificial Synapses || NeuroBeer Live #5
August 04, 2020 07:41 - 1 hour - 89.3 MB#psilocybin #ego #Psychotherapy #Psychedelics #synapse #glutamate #neuroscience We're Live at 8pm EDT to discuss new research investigating how psilocybin dissolves the ego and how biology can improve artificial synapses and Artifical intelligence. NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EST --------------------------------------------------------------------------------------------------------- Interested in Neuroscience research? Frustrated by hyped up media ...
Individual Differences in Addiction - Sign Tracking vs Goal Tracking || NeuroDrugs Live #4
August 04, 2020 07:29 - 2 hours - 125 MB#addiction #neuroscience #dopamine #wanting #liking #NeuroDrugs #live We're live tonight at 9pm to chat about individual differences in addiction! Why do some people get addicted while others don't? Why is it easier for some to quit while addicted while others struggle more? Why are some more vulnerable to craving and relapse than others? And what does learning and memory have to do with any of this? Today's paper is entitled "Individual differences in the attribution of incentive salience...
Addiction Biology- Dopamine, Motivation, & Habit Formation || NeuroDrugs Live #3
August 04, 2020 07:26 - 1 hour - 108 MB#addiction #opiates #memory #learning #reward #dopamine #neuroscience #NeuroBeer link to article: https://www.annualreviews.org/doi/abs/10.1146/annurev-psych-010418-103337 Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & di...
Drug Cues As Motivational Magnets - Incentive Salience Theory of Addiction || NeuroDrugs Live #2
August 04, 2020 07:24 - 1 hour - 88.8 MB#addiction #theories #neuroscience Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & nar...
History of Opiates - Addiction Neuroscience & Harms & Benefits || NeuroDrugs Live #1
August 04, 2020 07:16 - 2 hours - 121 MB#History #opiates #harms #benefits #neurobiology #neuroscience #addiction #science #live #livestream #askscience #medicine #addictionscience We're Live at 9pm to review the history of opiates, their potential harms & benefits of in the context of addiction and medical use, and the neuroscience of opiate addiction! Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-P...
How Everyone Can Stand Up To Science Misinformation | Roots Of First-Person Science | FPS#13
May 28, 2020 15:46 - 17 minutes - 15.8 MBIn this video we discuss the root causes and some extreme examples of fake news in science. How can we work together to stop this ongoing trend of misinformation and anti-science activism? The Media will often use strategies of selectivity to present a narrative that is most appealing to their financial interests (cannabis causes schizophrenia? Find out tonight at 6). However, these narratives do not work to benefit the public whatsoever. In fact, these techniques conceal particular informat...
Public Distrust In Science Explained | Why Media Is Wrong About Cannabis Science | FPS#12
May 21, 2020 14:41 - 28 minutes - 39.8 MBWhat is the value of science communication if there is distrust in the accuracy, completeness, or truthfulness of the information presented? Media will often use strategies of selectivity to present a narrative that is most appealing to their financial interests (cannabis causes schizophrenia? Find out tonight at 6), but do not work to benefit the public whatsoever. In fact, these techniques to conceal some information, while bringing other info to light actively works against the interest o...
How Nicotine Primes The Teenage Brain For Depression & Anxiety In Adulthood | FPS#11
May 16, 2020 03:03 - 34 minutes - 47.9 MBEducation about the health harms of tobacco have driven nicotine use down across all age groups for several decades. However, since 2016 the rate of adolescent and teenage nicotine use has nearly tripled, most commonly in the form of e-vapes (juuling). Although nicotine vapour May potentially be less harmful to overall health than tobacco smoke, a wealth of research identifies that nicotine exposure during adolescence or teenage years dramatically increases the risk for leader mental health ...
Your Brain In THC Vapor Clouds | Brain Waves In Cannabis Use & Psychosis | FPS#10
May 16, 2020 03:00 - 55 minutes - 76.5 MBMany claims have been made regarding the relation between cannabis use and psychiatric disorders, such as schizophrenia. The idea that frequent use of potent cannabis can elicit detrimental effects on cognition, learning & memory, & executive function is generally accepted. But how does THC, the main psychoactive compound in cannabis, produce changes in brain function that ultimately manifest as symptoms like psychosis that resemble that chief features of schizophrenia? And which brain regio...
How Tiny Touch Tablets For Mice Treat Alzheimer's | Big Data in Neuroscience | FPS#9
May 16, 2020 02:26 - 48 minutes - 66.3 MBNeuroscience Databases & mice-sized touchscreen tablets could change how we conduct science. What is big data? And how can it help us? Alzheimer's disease is a devastating, progressive disorder that causes degeneration of neurons in the brain responsible for memory. Alzheimer's disease represents the most common cause of dementia and includes continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. In this episode, Dr. Daniel P...
How Drugs & Drug-Linked Cues Strengthen Memory. Drug-Linked Cues Evoke Drug-Like Responses. FPS#8
April 07, 2020 21:06 - 50 minutes - 46.6 MBAddictive drugs are said to often worsen memory, and anecdotal reports of drug-users with poor memory are abundant. But what if these reports are wrong? What if drugs of abuse can improve memory under particular circumstances? In this episode, Michael Wolter - Neuroscience PhD Candidate from the University of Guelph - joins us to discuss how Heroin and other drugs of abuse (including cocaine & nicotine) can enhance memory for events immediately preceding drug intake. This work has vast impli...
How Drugs & Drug-Associated Cues Strengthen Memory. Pavlovian Conditioning & Consolidation. FPS#8
April 07, 2020 21:06 - 50 minutes - 46.6 MBWhat if drugs of abuse can improve memory under particular circumstances? In this episode, Michael Wolter - Neuroscience PhD Candidate from the University of Guelph - joins us to discuss how heroin and other drugs of abuse (including cocaine & nicotine) can enhance memory for events immediately preceding drug intake.
How a Colorless Gas Controls Brain's Immune System. FPS#7
March 18, 2020 01:46 - 55 minutes - 76.2 MBWe discuss the mechanisms that regulate microglia phagocytosis (such as TRPV2 and other vanilloid receptors) - AKA eating apoptosis ready cells - and how the brain maintains healthy function in aging and after injury, such as traumatic brain injury (TBI).Because neurons get all the attention, you don't hear too much about glia. Although glia cells DO NOT carry nerve impulses (action potentials) they do have many important functions. In fact, without glia, the neurons would not work properly!...
How Do EndoCannabinoids Buffer Stress? Cannabinoid Collapse Causes Synaptic Strengthening. FPS #6
February 26, 2020 22:22 - 1 hour - 86.2 MBEndocannabinoids - cannabinoids made in the body, by the body - are a Hot Topic in Neuroscience & Beyond - with Western & integrative medicine coming to embrace the role of these important compounds, the EndoCannabinoid system is emerging as a therapeutic target for treatment of several psychiatric disorders. However, endocannabinoid system research is limited by scientists' ability to translate these groundbreaking research discoveries into clinical treatments, mostly due to a lack of under...
Solving Cannabis Hyperemesis Syndrome. FPS#5
February 23, 2020 21:49 - 54 minutes - 74.9 MBWhy do cannabinoids in cannabis cause nausea and vomiting in some people but not others? Is this limited to heavy users, Recreational users, medicinal cannabis patients? In this episode, FPS ventures into the unknown on the very under-researched area of Cannabinoid Hyperemesis Syndrome. In this episode neuroscience PhD candidate Marieka Devuono joins us to speak about her recently published manuscript that addresses these controversial concepts, entitled "Conditioned gaping produced by high ...
Understanding Human-Depression By Studying Rodents? Symptoms, Causes & Treatments. FPS#4
February 03, 2020 18:33 - 26 minutes - 35.9 MBThe discovery of biomarkers related to depression and other psychiatric disorders have been accelerated in recent years due to emphasis on genomics and proteomics research, Precision medicine (or personalized medicine), and collaborative approaches across research labs. Using knowledge of these biomarkers, scientists are better able to identify of those with genetic predispositions, as well as improve diagnosis, treatment, and prognosis for those with depression (MDD). In this episode neuros...
FPS#4: How Can We Learn About Human-Depression By Studying Rodents?
February 03, 2020 18:33 - 26 minutes - 35.9 MBIs it possible to study Depression, a uniquely human disorder, using knowledge from experiments in rats and mice? In this episode, Dr. Stephen Daniels joins us to speak about his recently published manuscript entitled "Reverse Translation of Major Depressive Disorder Symptoms: A Framework for the Behavioural Phenotyping of Putative Biomarkers", from The Journal of Affective Disorders.
Can We Understand Human-Depression By Studying Rodents? Symptoms, Causes & Treatments. FPS#4
February 03, 2020 18:33 - 26 minutes - 35.9 MBIs it possible to study Depression, a uniquely human disorder, with knowledge from experiments in rats and mice? Dr. Stephen Daniels speaks about his recently published manuscript entitled "Reverse Translation of Major Depressive Disorder Symptoms: A Framework for the Behavioural Phenotyping of Putative Biomarkers" from The Journal of Affective Disorders.
FPS#3: Instinctual Fear Responses to Aerial Predator Stimuli: Sex-Dependent Differences in Rats
January 25, 2020 22:04 - 39 minutes - 54.4 MBIn Episode #3 of First-Person Science, Roger Hudson speaks with PhD Candidate Peter Zambetti from the University of Washington about his recently published manuscript enitled, "Sex Differences in Foraging Rats to Naturalistic Aerial Predator Stimuli", published in iScience from CellPress [Volume 16, 28 June 2019, Pages 442-452] / DOI:10.1016/j.isci.2019.06.011.
Learned Fear & Anxiety in Nature: Sex-Dependent Differences in Rats. FPS #3
January 25, 2020 22:04 - 39 minutes - 54.4 MBThe amygdala is a prominent brain region known for its involvement in learning and memory in emotional situations including during fear, anxiety, and pleasure - including its activation in the fight or flight response. However, this psychology related research has taken place almost exclusively in laboratory environments with limited ability to generalize to natural settings that rodents would be instinctually prepared to learn in. How the amygdala processes this information in more natural...
Highs & Lows of Marijuana: How CBD Blocks Schizophrenia - Like Side Effects of THC. FPS #2
January 14, 2020 15:19 - 36 minutes - 67.7 MBEvidence suggests that THC and CBD each act on specific receptors in the brain to cause different effects on Biomarkers, other neurotransmitter systems and molecular pathways. In fact, CBD can even prevent many of the side effects associated with potent cannabis (high THC cannabis) such as psychosis, paranoia, and in some cases can act as a treatment for those diagnosed with schizophrenia. In this episode of First-Person Science, PhD Candidate & Vanier Scholar Roger Hudson speaks about his r...
FPS #2: CBD Counteracts the Psychotropic Side-Effects of THC in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation w/ Roger Hudson
January 14, 2020 15:19 - 36 minutes - 67.7 MBIn this episode of First-Person Science, Thomas Lapointe speaks with Roger Hudson about his recently published manuscript entitled, "CBD Counteracts the Psychotropic Side-Effects of THC in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation", published in The Journal of Neuroscience [2019 Oct] / DOI:10.1523/JNEUROSCI.0708-19.2019.
FPS #1: Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor w/ Thomas Lapointe
January 08, 2020 01:17 - 28 minutes - 25.3 MBIn this inaugural episode of First-Person Science, Roger Hudson speaks with Thomas Lapointe about his recently published manuscript entitled, "Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor", published in Psychopharmacology [2019 Jul;236(7):2273-2281] / DOI:10.1007/s00213-019-05225-z.
How Scientists Are Increasing Antidepressant Effectiveness To Better Treat Depression. FPS #1
January 08, 2020 01:17 - 28 minutes - 25.3 MBIn this inaugural release of First-Person Science, Roger Hudson speaks with Thomas Lapointe about his recently published manuscript that explores the behavioural and brain mRNA effects of combined escitalopram (an SSRI; antidepressant) and adjunct aripiprazole (5-HT1a agonist) in rats, with a specific focus on the 5-HT1a receptor. This podcast also discusses how scientists are enhancing the therapeutic efficacy of antidepressants and some of the mechanisms involved. "Effects of combined esci...