Discovery Matters
113 episodes - English - Latest episode: about 2 months ago - ★★★★★ - 19 ratingsA collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.
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Episodes
Microbiome transplant: cooties can cure you
November 18, 2019 09:48 - 18 minutes - 41.5 MBConor has, what he calls "microbiomania". Whatever the topic, he is able to bring it back to microbiomes in about 3 sentences. So imagine how excited he was to interview Colleen Cutcliffe, CEO of Pendulum whose mission is to make millions healthier through microbiome-targeted medical solutions. Another guest on this episode is Jacques Ravel, professor extraordinaire of The Human Microbiome and Women's Health at the Institute for Genome Sciences, University of Maryland. Enjoy ! (We sure did...
7. Fitness trackers in the 1940s: The Framingham Heart Study
November 01, 2019 07:11 - 14 minutes - 33 MBDuring a lively lunch chat about the popularity of wearable fitness trackers, the curious question came up: with all this data we are generating, what if we were able to do it 50-70 years ago - where would medicine and healthcare be now? Hearing the question Dodi immediately remembered The Framingham Heart Study. Its objective was to identify the common factors or characteristics that contribute to cardiovascular disease (CVD) by following its development over a long period of time in a lar...
6. Fitness trackers in the 1940s: The Framingham Heart Study
November 01, 2019 07:11 - 14 minutes - 33 MBDuring a lively lunch chat about the popularity of wearable fitness trackers, the curious question came up: with all this data we are generating, what if we were able to do it 50-70 years ago - where would medicine and healthcare be now? Hearing the question Dodi immediately remembered The Framingham Heart Study. Its objective was to identify the common factors or characteristics that contribute to cardiovascular disease (CVD) by following its development over a long period of time in a lar...
6. CAR-T cell therapy: the story of 2 brave young women fighting cancer
October 18, 2019 08:39 - 21 minutes - 50.1 MBThis episode is a more immediately serious story than previous topics we've covered. This story is about a discovery where a number of people had to go through unimaginable pain so that it can become useful for others. This is the story of Emily Whitehead, the first pediatric patient enrolled in a clinical trial investigating CAR T-cell therapy CTL019, now known as tisagenlecleucel, at Children’s Hospital of Philadelphia (CHOP). Emily is now a happy, healthy 14-year-old in remission for t...
5. CAR-T cell therapy: the story of 2 brave young women fighting cancer
October 18, 2019 08:39 - 22 minutes - 50.7 MBThis episode is a more immediately serious story than previous topics we've covered. This story is about a discovery where a number of people had to go through unimaginable pain so that it can become useful for others. This is the story of Emily Whitehead, the first pediatric patient enrolled in a clinical trial investigating CAR T-cell therapy CTL019, now known as tisagenlecleucel, at Children’s Hospital of Philadelphia (CHOP). Emily is now a happy, healthy 14 year old in remission for t...
5. A map of humankind from the inside out
August 21, 2019 09:33 - 21 minutes - 48.2 MBWe humans have been mapping things since the beginning of time. In our endless quest to figure ourselves and our world out, there are projects galore. Does the 150-year-old periodic table ring any bells? In this episode, Dodi takes Conor on an explorer’s journey, destination: Human Protein Atlas project. Strap on your seatbelt, it’s a bumpy ride connecting the dots between explorers, chemists, geneticists…and even sociologists! Transcript Keyword: atlas, periodic table, proteins, maps...
4. A map of humankind from the inside out
August 21, 2019 09:33 - 21 minutes - 48.2 MBWe humans have been mapping things since the beginning of time. In our endless quest to figure ourselves and our world out, there are projects galore. Does the 150 year old periodic table ring any bells? In this episode Dodi takes Conor on an explorer’s journey, destination: Human Protein Atlas project. Strap on your seatbelt, it’s a bumpy ride connecting the dots between explorers, chemists, geneticists…and even sociologists!
Bonus episode: The role of AI in healthcare, more specifically pandemics
July 30, 2019 14:09 - 13 minutes - 30.1 MBA pandemic starts with a picnic. But can pandemics be prevented without cancelling feel-good gatherings? Enter Artificial Intelligence into the world of healthcare and life sciences. Dodi meets up with an expert panel on the topic and gets examples of the real potential of this very trendy topic.
4. Bonus episode: The role of AI in healthcare, more specifically pandemics
July 30, 2019 14:09 - 13 minutes - 30.1 MBA pandemic starts with a picnic. But can pandemics be prevented without cancelling feel-good gatherings? Enter Artificial Intelligence into the world of healthcare and life sciences. Dodi meets up with an expert panel on the topic and gets examples of the real potential of this very trendy topic.
4. The role of AI in pandemics
July 30, 2019 14:09 - 13 minutes - 30.1 MBA pandemic starts with a picnic. But can pandemics be prevented without cancelling feel-good gatherings? Enter Artificial Intelligence into the world of healthcare and life sciences. Dodi meets up with an expert panel on the topic and gets examples of the real potential of this very trendy topic. Transcript Keywords: pandemics, ai, data, infectious diseases, healthcare, outbreak, ebola outbreak, ebola crisis, predict, data sources, spread, humanitarian, infections.
1. Tea and jam and protein separation
July 12, 2019 07:05 - 17 minutes - 17.7 MBDodi and Conor discover how jam played a part in paving the way for biopharmaceutical drugs. 60 years ago, Swedish scientists happened upon a new method of protein separation through chromatography. The very same technique continues to be the foundation for modern biomedical manufacturing. Transcript Keywords: protein separation, chromatography, dextran, jam, protein, gel, Swedish, pectin, affinity chromatography, develop, column, antibodies, separate, pharmacy, sugar, biomedical manufactu...
2. When a hamster rules the biopharma world
July 12, 2019 07:05 - 17 minutes - 17.5 MBLittle did you know, but a single hamster has been a force of innovation and massive biomedical production. Scientists devote entire careers to so-called CHO cells from this Chinese hamster’s ovary. Dodi and Conor meet a couple of them to figure out why this hamster rules the biopharma world. Transcript Keywords: cells, protein, hamster, CHO, patient, dna molecules.
3. Kidney surgeon who fixes the plumbing
July 12, 2019 07:04 - 18 minutes - 20.2 MBThe list of people needing kidney transplants is tragically long, and donor lists are desperately short. Conor and Dodi find scientists who are coming up with alternative solutions to this problem. Some enable transplantation of less-than-perfect organs, and others dream of 3D printing important organs. Transcript Keywords: organ, transplant, dialysis, kidney, transplantation, donors, patient, organ donation, surgeon, repairing, biomedical.