In this edition, we learn about about how the poison botulinum toxin alters cell functions, with K. Ravi Acharya (00:00) (Trends in Biochemical Sciences), how recording electrical activity from neurons in awake humans, with Rodrigo Quian Quiroga (8:20) (Neuron) and how dynamic changes in genetic material called chromatin control key features of cell function, with Tom Misteli (15:35) (special issue of Trends in Cell Biology). Plus more great research highlights from around Cell Press (25:00).