CCO Neuroscience Podcast
31 episodes - English - Latest episode: 9 months ago - ★★★★★ - 3 ratingsUpdates on new data and best practices in patient care across a wide variety of psychiatric and neurological illnesses from Clinical Care Options. Gain a deeper understanding and practical clinical insights on topics ranging from bipolar depression to Parkinson’s disease psychosis. Select episodes available for CME/CE credit.
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Episodes
Assess the Efficacy and Safety of Emerging Strategies That Impact Brain Cholesterol Turnover
November 03, 2023 18:36 - 23 minutes - 21.2 MBLink to CME: Claim Credit - https://bit.ly/3OByCaE In this episode, Drs. Halford and Hahn discuss the current treatment landscape of developmental and epileptic encephalopathies (DEEs), such as Lennox-Gastaut syndrome and Dravet syndrome, and the emerging role of brain cholesterol in addressing seizure frequency. The full episode covers: How to diagnose these epilepsies and the FDA-approved treatment options in the first-line and second-line settings The role of antiseizure medications in...
Brain Cholesterol: The New Landscape of Neurological Disease Management
November 01, 2023 13:35 - 29 minutes - 26.7 MBLink to CME: Claim Credit - https://bit.ly/3wbVkA1 In this episode, Drs. Halford and White discuss the emerging role of brain cholesterol in the development and potential treatment of neurological diseases like epilepsy or Alzheimer and Huntington diseases. The full episode covers: Overview of brain cholesterol and its function in the body Pathogenesis potential for certain diseases via brain cholesterol Emerging research on a cholesterol synthase inhibitor as a novel therapy The future...
Defining Alzheimer’s Disease and MCI Management in the Modern Era
October 31, 2023 20:57 - 24 minutes - 22.8 MBIn this episode, Drs. Sabbagh and Isaacson discuss how to best approach Alzheimer’s disease (AD) and mild cognitive impairment (MCI) in clinical practice, including accurately diagnosing patients and optimizing treatment in terms of patient preferences and reimbursement options. The full episode covers: Defining AD and MCI and their clinical presentation How to diagnose AD vs MCI Reimbursement landscape for current diagnosing and monitoring tools Precision medicine’s evolving role in dia...
Keeping Up With the Treatment Landscape for MDD
August 01, 2023 15:14 - 28 minutes - 26.4 MBThe treatment landscape of major depression is increasingly shifting from monoaminergic agents to agents that modulate glutamate and GABA. Healthcare professionals need to stay up to date and educated on these changes in order to discuss the most current treatment options with their patients. In this podcast episode, we interview Dr Anita Clayton, a clinician researcher who has been involved in some of the clinical trials for these novel glutamatergic and GABAergic medications, and ask her k...
Rett Syndrome Tomorrow: Management Options on the Horizon
March 27, 2023 19:30 - 22 minutes - 20.8 MBRett syndrome is a rare but severe neurodevelopmental disorder, and current treatment approaches primarily focus on symptom management and supportive care. However, recent clinical developments are providing hope for a changing treatment landscape. In this podcast episode, experts in Rett syndrome David N. Lieberman, MD, PhD, and Jeffrey Neul, MD, PhD, discuss trofinetide and blarcamesine, 2 agents in late-stage clinical trials as treatment options for Rett syndrome. Throughout their convers...
Rett Syndrome Today: Current Options for Symptom Management
March 02, 2023 05:00 - 32 minutes - 30 MBRett syndrome affects many organ systems, and each patient has individual symptoms and experiences—there is no “one-size-fits-all” treatment approach. In this podcast episode, Rett syndrome experts David N. Lieberman, MD, PhD, and Shannon Standridge, DO, MPH, discuss some of the more common manifestations of Rett syndrome and current management strategies. While covering manifestations such as epilepsy, behavioral issues, and gastrointestinal distress, they highlight the value of a team appr...
Long-term Solutions for Long-term Diseases: Using Long-Acting Injectable Antipsychotics in Practice
January 18, 2023 21:30 - 29 minutes - 26.8 MBIn this podcast episode, Leslie Citrome, MD, MPH, and Adam Lowy, MD, share a wealth of knowledge about long-acting injectable (LAI) antipsychotics. Their conversation begins with an overview of the pharmacokinetic profiles of LAI antipsychotics and how they differ from their oral counterparts, as well as injection intervals available with current formulations. The experts also discuss the clinical utility of LAI antipsychotics in psychiatry practice, highlighting their role in assuring medic...
Rett Syndrome Today and Tomorrow: What Is Rett Syndrome?
January 18, 2023 21:30 - 29 minutes - 27.5 MBIn this podcast episode, experts in Rett syndrome, David N. Lieberman, MD, PhD, and Jeffrey Neul, MD, PhD, provide a comprehensive overview of Rett syndrome (RTT), a rare but severe neurodevelopmental disorder. They begin with a discussion on the clinical characteristics and typical disease progression of RTT before diving into the various genetic markers and how they may, or may not, be used in the diagnosis and prognosis. Finally, the experts ponder the future of RTT diagnoses, touching up...
To the Rescue: Incorporating Rescue Medications Into Epilepsy Treatment Plans
January 04, 2023 21:10 - 28 minutes - 25.8 MBIn this podcast episode, epileptologists Aatif Husain, MD, and John Stern, MD, have a conversation about rescue therapies and how they fit into the spectrum of epilepsy management. Their discussion begins with sharing what they consider the utility of rescue therapies to be in the overall spectrum of epilepsy. As the conversation goes on, they address the role of rescue therapies in more specific patient populations, such as the newly diagnosed patient, a patient experiencing seizure cluster...
Halting Hallucinations: A Discussion of Management Strategies for Parkinson’s Disease Psychosis
January 04, 2023 16:00 - 24 minutes - 22.2 MBIn this podcast episode, Marwan Sabbagh, MD, FAAN, and Marta San Luciano, MD, MS, FAAN, have a conversation about Parkinson’s disease psychosis (PDP). Their discussion provides information on the disease itself—covering symptoms, risk factors, and mechanism—before moving into clinical strategies for diagnosis and disease and comorbidity management. The experts emphasize the importance of ruling out an underlying cause of psychosis before making a diagnosis of PDP, calling out common culprits...
Tardive Dyskinesia Etiology: Risks and Considerations
December 29, 2022 21:50 - 20 minutes - 19.1 MBIn this episode, Christoph U. Correll, MD, and John M. Kane, MD, discuss the various etiologies of tardive dyskinesia (TD). Although most healthcare professionals are aware of the risk for TD that comes with first- and second-generation antipsychotic use, there is less awareness around other modifiable and unmodifiable factors that increase risk for TD development. Some modifiable risks include metoclopramide use, anticholinergic use, and substance use disorder; unmodifiable risks include ol...
Bipolar Disorder Research to Look For in 2023
December 07, 2022 21:30 - 24 minutes - 22.1 MBIn this episode, Greg W. Mattingly, MD, and Vladimir Maletic, MD, have a conversation about the ongoing bipolar disorder research and developments expected to have an impact in the coming year. They elaborate on the various neurotransmitters being investigated and how this research might change the future of patient care. From investigating new mechanisms of action to increased uptake of more novel therapeutics such as esketamine and neuromodulation, there is a lot to look forward to. As th...
Answering Your Questions About Tardive Dyskinesia
December 06, 2022 21:30 - 22 minutes - 20.9 MBGet answers to the questions that you and your colleagues have asked! In this episode, Jonathan M. Meyer, MD; Leslie Citrome, MD, MPH; and Stuart Isaacson, MD, provide answers to audience questions that were submitted at recent CCO Psychiatry meetings. Their thoughtful responses cover your questions on screening, communicating with patients, medication management, and more. Moderators Rajesh Pahwa, MD; Charles DeBattista, DMH, MD; and Greg W. Mattingly, MD, provide complementary commentary t...
Symptom Management in Bipolar Depression: Realistic Expectations and Strategies for Improvement
November 01, 2022 20:30 - 29 minutes - 27.3 MBIn this episode, Joseph F. Goldberg, MD, and Roger McIntyre, MD, FRCPC, shed light on the symptom improvement timeline in bipolar depression. This is a topic made more complex when factoring in individual patient characteristics and comorbidities, but the 2 experts have astute insights on how to tailor a management plan based on such factors. They cover symptom management and improvement from a variety of angles, including evaluating improvement in functionality and mood, guidance on follow-...
A Comprehensive Look at Tardive Dyskinesia Management
October 28, 2022 20:30 - 22 minutes - 20.8 MBIn this podcast episode, Robert O. Cotes, MD, and Jonathan M. Meyer, MD, discuss tardive dyskinesia from identification to follow-up and ongoing management. They provide valuable insights on pharmacologic options to both consider and avoid to optimize outcomes in patients with tardive dyskinesia, including a focus on clinical strategies for use of VMAT2 inhibitors. Presenters: Robert O. Cotes, MD Associate Professor Department of Psychiatry and Behavioral Sciences Emory University School o...
Pharmacologic Management Options for Patients With Tardive Dyskinesia
October 17, 2022 20:30 - 35 minutes - 32.8 MBIn this podcast episode, Diana O. Perkins, MD, MPH, and Rajiv Tandon, MD, provide a wealth of information on VMAT2 inhibitors and their use for tardive dyskinesia (TD) management. Their discussion includes information on VMAT2 inhibitor emergence in clinical practice, mechanism of action, adverse event profiles, insurance coverage, and strategies for initiation and titration. In addition to VMAT2 inhibitors, the experts touch on off-label options for TD management and their place in the TD m...
Treatment Considerations Across the Bipolar Depression Spectrum
October 06, 2022 20:00 - 25 minutes - 23.2 MBIn this episode, Greg W. Mattingly, MD, and Vladimir Maletic, MD, share their thoughts on treatment strategies across the bipolar depression spectrum. They begin by talking about their stance on treating bipolar with comorbidities with a holistic vs stepwise approach and discuss what strategies they would consider for a patient not yet diagnosed with but who is at risk of developing bipolar depression. In addition, they discuss the concept of phase-specific treatment, considerations for medi...
Patient Interview: Living With Tardive Dyskinesia
September 28, 2022 16:00 - 16 minutes - 15.5 MBIn this podcast episode on tardive dyskinesia (TD), Joseph P. McEvoy, MD, interviews Leslie, a patient who was diagnosed with TD 10 years ago. She describes her journey to an accurate diagnosis, the impact that TD has on her daily life, and her advice for patients and providers affected by TD. Presenters: Joseph P. McEvoy MD Professor Psychiatry and Health Behavior Psychiatrist Augusta University Augusta, Georgia Leslie This content is based on a CE/CME program supported by independent e...
Diagnosis Detective: Accurately Identifying Bipolar Depression
September 02, 2022 17:05 - 29 minutes - 27.3 MBIn this episode, Greg W. Mattingly, MD, and Vladimir Maletic, MD, have a conversation about the complexities of accurately diagnosing bipolar depression. Bipolar depression can be difficult to differentiate from other psychiatric conditions, such as unipolar depression, depression with mixed features, ADHD, PTSD, and anxiety. This differential is made more challenging in that patients with bipolar depression often have psychiatric comorbidities with overlapping symptomology. Listen as the 2 ...
Answering Your Questions About Bipolar Depression
August 01, 2022 20:00 - 16 minutes - 15 MBGet answers to the questions that you and your colleagues have asked! In this episode, Charles DeBattista, MD, provides answers to audience questions that were submitted at 2 recent Psychiatry Update meetings. His thoughtful responses cover your questions on differential diagnosis, initiating pharmacotherapy, medication management, and more. Moderators Amber Hoberg, PMHNP, and Greg W. Mattingly, MD, provide complementary commentary throughout the Q&A session, adding interprofessional perspec...
How Can We Screen for and Identify Tardive Dyskinesia?
July 11, 2022 17:00 - 23 minutes - 21.3 MBIn this first of 6 podcast episodes on tardive dyskinesia (TD), Drs Greg W. Mattingly and Jonathan M. Meyer have a discussion on identifying TD in clinical practice—including how to effectively screen patients during telehealth appointments. They cover who should be screened and how often, informal vs formal screening, and the valuable insight that family/caregiver reports can provide in the identification process. Additional conversation sheds light on differentiating TD from other movement...
A Comprehensive Overview of the Bipolar Spectrum
July 07, 2022 20:45 - 19 minutes - 17.7 MBIn this episode, Drs Greg W. Mattingly and Charles DeBattista have a conversation about the history and features of the bipolar spectrum. Because patients can present in mixed vignettes, diagnosis of bipolar depression can be challenging. The experts offer insight on when to hold a suspicion for bipolar depression, as well as common presentations they have seen over their years in clinical practice. The conversation then progresses to potential “triggers” of bipolar depression and culminates...
The Functional and Social Impact of TD on the Lives of Patients
January 11, 2022 18:30 - 27 minutes - 25.1 MBIn this episode, Diana Perkins, MD, MPH, and Martha Sajatovic, MD, discuss the impact of tardive dyskinesia on social and functional domains and the benefits of proper assessment and treatment of tardive dyskinesia in improving patient quality of life in these areas. Presenters: Diana Perkins, MD, MPH Professor of Psychiatry University of North Carolina School of Medicine Chapel Hill, North Carolina Martha Sajatovic, MD Professor of Psychiatry and Neurology Departments of Psychiatry and...
Evidence-Based Approaches to Choosing the Right Treatment for Bipolar Depression
November 30, 2021 17:00 - 30 minutes - 27.8 MBIn this episode, Roger McIntyre, MD, FRCPC, and Sanjay Mathew, MD, discuss choosing the right treatment in bipolar depression. They review patient assessment and differential diagnosis for bipolar depression, describe various screening tools, examine evidence-based pharmacotherapies, consider the role of adjunctive antidepressants, neuromodulation, light therapy, and psychological treatments, and explore future directions in bipolar depression treatment. Presenters: Sanjay J. Mathew, MD ...
Multidisciplinary Approach to Evaluation and Treatment of Tardive Dyskinesia
November 16, 2021 19:20 - 26 minutes - 24.1 MBIn this episode, Greg Mattingly, MD, and W. Clay Jackson, MD, DipTh, discuss who PCPs should screen for TD, adverse effects PCPs should put on their radar screen when monitoring patients on antipsychotics, how TD is different from parkinsonism, the use of anticholinergics, and which patients have an increased risk for TD when on antipsychotics. Presenters: Greg Mattingly, MD Associate Clinical Professor Psychiatry, Psychopharmacology Washington University School of Medicine St Louis, Mis...
What Is the Role for Antidepressants in Bipolar Disorder?
October 05, 2021 20:00 - 34 minutes - 31.9 MBIn this episode, Joseph Goldberg, MD, and Greg Mattingly, MD, discuss the role of antidepressants in bipolar disorder. They review use of newer antidepressants (eg, vortioxetine, vilazodone) for bipolar depression despite lack of large, formal studies for that indication, the safety/efficacy of antidepressants for bipolar II vs bipolar I, antidepressant monotherapy in bipolar II depression, ketamine/esketamine for bipolar depression, and discuss the role for an antidepressant for bipolar dep...
Diagnostic Dilemmas in Differentiating Unipolar and Bipolar Depression
August 20, 2021 20:35 - 31 minutes - 28.9 MBIn this episode, Leslie Citrome, MD, MPH, and Manpreet K. Singh, MD, MS, discuss diagnosing unipolar vs bipolar depression. They review why it can be difficult to differentiate between unipolar and bipolar depression; which screening tools they employ, including the rapid mood screener (RMS); how to reduce chances of missing mania; and special tips for differentiating between major depressive disorder (MDD) and bipolar depression in children. Presenters: Leslie Citrome, MD, MPH Clinical ...
Dilemmas in TD in Primary Care
August 20, 2021 20:30 - 31 minutes - 28.6 MBIn this episode, Greg Mattingly, MD, and W. Clay Jackson, MD, DipTh , discuss how the use of antipsychotics has changed in primary care patients, how primary care physicians can screen for tardive dyskinesia (TD), and increasing needs for the primary care physician in mental health. Presenters: Greg Mattingly, MD Associate Clinical Professor Psychiatry, Psychopharmacology Washington University School of Medicine St Louis, Missouri President St Charles Psychiatry Associates St Charles, Miss...
Relationship of EPS, Antiparkinsonian Drugs, and TD
July 20, 2021 20:30 - 30 minutes - 28.3 MBIn this episode, John M. Kane, MD, and Rebecca S. Roma, MD, discuss clinical assessment of extrapyramidal symptoms (EPS), antiparkinsonian drugs, and tardive dyskinesia (TD). They review differentiating between TD and EPS, identify tools for diagnosing TD, and provide some important clinical pearls and evidence-based reasons for choosing different medications for treating EPS and TD. Presenters: John M. Kane, MD Professor and Chairman Department of Psychiatry Donald and Barbara Zucker Scho...
Diagnosing TD in Clinical Practice
June 11, 2021 23:00 - 28 minutes - 26.1 MBIn this episode, Leslie Citrome, MD, MPH, and Joseph P. McEvoy, MD, discuss clinical assessment and diagnosis of tardive dyskinesia (TD). They review using the AIMS exam for identification of dyskinesia in patients in both the clinical setting and via telepsychiatry. They also review how often to perform the AIMS exam, how to assess the results, and why it is important. Presenters: Leslie Citrome, MD, MPH Clinical Professor Department of Psychiatry and Behavioral Sciences New York Medical C...
Mood Disorders, Antipsychotics, and TD
May 24, 2021 20:30 - 35 minutes - 32.8 MBIn this episode, Roger McIntyre, MD, FRCPC, and Joseph Goldberg, MD, discuss tardive dyskinesia (TD), mood disorders, and antipsychotics. They review current clinical considerations and assessments, including whether antipsychotic prescriptions for mood disorders have increased, if patients with mood disorder are at higher risk for TD and why, and when and how to use an AIMS exam, even in telepsychiatry. They also review the evidence base for VMAT2 inhibitors in TD, what nonevidence-based tr...