Translating Aging
53 episodes - English - Latest episode: 27 days ago -On Translating Aging, we talk with the worldwide community of researchers, entrepreneurs, and investors who are moving longevity science from the lab to the clinic. We bring you a commanding view of the entire field, in the words of the people and companies who are moving it forward today. The podcast is sponsored by BioAge labs, a clinical-stage biotechnology company developing therapies to extend human healthspan by targeting the molecular causes of aging.
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Episodes
Delaying menopause, extending healthspan: The promise of AMH-based therapeutics (Daisy Robinton, Oviva Therapeutics)
April 03, 2024 07:30 - 36 minutes - 25.1 MBDr. Daisy Robinton, co-founder and CEO of Oviva Therapeutics, discusses the company's innovative approach to improving women's healthspan by targeting the biology of ovarian aging. Motivated by her personal experiences and the realization that female physiology is underserved by research and medicine, Daisy outlines how menopause is a key inflection point in the acceleration of aging in women. She explains the central role of anti-Mullerian hormone (AMH) in regulating ovarian function and fe...
Gene Therapies to Treat and Reverse Aging (Noah Davidsohn, Rejuvenate Bio)
March 20, 2024 16:15 - 35 minutes - 24.2 MBDr. Noah Davidsohn, co-founder and CSO of Rejuvenate Bio, discusses the company's innovative work using gene therapies to treat age-related diseases in dogs and humans. In his conversation with host Chris Patil, he explains his recent groundbreaking study showing that partial cellular reprogramming with Yamanaka factors extended lifespan and healthspan in very old mice. Noah then outlines Rejuvenate's clinical pipeline, including targeting longevity pathways like FGF-21 for heart disease and...
30 Years of Aging Biology: A Pioneer's Perspective (Cynthia Kenyon, VP-Aging Research at Calico Labs)
December 06, 2023 07:30 - 44 minutes - 30.3 MB30 Years of Aging Biology: A Pioneer’s Perspective (Cynthia Kenyon - VP Aging Biology, Calico Labs) Dr. Cynthia Kenyon reflects on the evolution of the longevity field over the 30 years since the publication of her groundbreaking paper, “A C. elegans mutant that lives twice as long as wild type,” a genetic analysis of one of the first single-gene mutations to extend lifespan in the worm. She recounts the initial excitement and skepticism around the idea of a pathway that regulates aging, an...
XPRIZE Healthspan: Catalyzing Therapies for Aging (Jamie Justice, PhD)
November 29, 2023 15:30 - 55 minutes - 37.9 MBDr. Jamie Justice is Executive Director of the newly launched XPRIZE Healthspan, a $101 M international competition to accelerate therapeutics targeting aging biology. In conversation with host Chris Patil, Dr. Justice outlines the motivation, structure, and timeline of the prize, as well as how teams can get involved. She also explains unique aspects of this prize, including the public commentary period, how existing trials can be adapted for competition, functional endpoints, and judging c...
"How We Age: The Science of Longevity" (Professor Coleen Murphy, Princeton)
November 01, 2023 07:30 - 36 minutes - 25.1 MBDr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field. Key ideas: Addressing ethical concerns about studying aging and longevity Defining aging conceptually and how metrics like lifespan vs. healthspan are measured Using genetics,...
From Startup to Acquisition (Nick Hertz, Mitokinin)
October 11, 2023 07:30 - 41 minutes - 28.8 MBDr. Nicholas Hertz is the co-founder and former CSO of Mitokinin, a biotech company developing therapies targeting damaged mitochondria in neurodegenerative disease. Mitokinin was recently acquired by pharmaceutical giant AbbVie. In this episode, Nick recounts the journey from academic research on PINK1 biology to founding a startup and advancing a clinical candidate. He provides insights into the drug discovery process, optimizing lead compounds, translating basic findings into therapies, a...
Catalyzing moonshots in longevity biotech (Alex Colville, Age1)
September 27, 2023 07:30 - 40 minutes - 27.8 MBDr. Alex Colville is the co-founder and General Partner of Age1 Ventures, a recently launched VC firm focused on funding contrarian, founder-led biotech companies aiming to extend healthy human lifespan. In this episode, Alex outlines Age1's thesis of identifying and empowering talented founders with ambitious visions for the longevity field. He shares his own journey to VC, including early interests in aging science and entrepreneurship. Alex provides an inside look at Age1's approach to co...
Reversing Skin Aging at the Cellular Level (Carolina Reis Oliveira and Alessandra Zonari, OneSkin)
August 23, 2023 07:30 - 35 minutes - 24.6 MBDr. Carolina Reis Oliveira and Dr. Alessandra Zonari are the co-founders of OneSkin, a company developing science-backed skincare products to reverse skin aging at the cellular level. In this episode, Carolina and Alessandra tell host Dr. Chris Patil how OneSkin is leveraging recent advances in longevity science to create novel peptides that target senescent cells and inflammation in aged skin. Their lead ingredient, OS-1, is a peptide capable of reducing biological age and senescence burden...
Discovering New Senolytics with Neural Networks (Felix Wong, Integrated Biosciences)
August 09, 2023 07:30 - 37 minutes - 25.4 MBDr. Felix Wong is a co-founder of Integrated Biosciences, an early-stage biotech company developing next-generation therapeutics for cellular rejuvenation. He is also a postdoc at MIT and the Broad Institute and was a lead author on a recent Nature Aging paper describing the use of graph neural networks to discover new senolytic compounds. In this episode, Felix and host Chris Patil have an in-depth discussion about using machine learning to accelerate drug discovery, specifically to target...
“Taking disease by sTORm”: Developing Rapalogs to Extend Healthy Lifespan (Joan Mannick, Tornado Therapeutics)
July 26, 2023 07:30 - 29 minutes - 20.1 MBJoan Mannick, CEO and co-Founder of Tornado Therapeutics, joins the podcast to discuss her company’s exciting mission of developing a new generation of rapalog compounds specifically targeting the TORC1 complex. Rapalogs are analogs of the natural compound rapamycin, which has been shown to extend lifespan and healthspan in animal models by inhibiting the TOR pathway. However, rapamycin has limitations that have prevented its widespread clinical use for aging-related conditions. Tornado aim...
Discovering Healthspan Interventions through Phenotype-Based Drug Screening (Mitchell Lee, Ora Biomedical)
July 12, 2023 07:30 - 32 minutes - 29.5 MBMitchell Lee is the CEO and co-founder of Ora Biomedical, a Seattle-based biotech company using large-scale phenotypic drug screening in C. elegans to discover small molecule therapeutics that extend lifespan and healthspan. In this episode, Chris and Mitch discuss Ora's approach to drug discovery, which focuses on function and phenotype rather than specific targets or mechanisms. Using their proprietary "WormBot" platform, Ora screens thousands of compounds in parallel to identify molecule...
Synergizing Synbio & Longevity: A Panel Discussion at SynBioBeta 2023
May 31, 2023 07:30 - 42 minutes - 29.2 MBThis special episode features a panel discussion moderated by Chris Patil at the 2023 SynBioBeta conference. The panel brings together leaders from the synthetic biology and longevity communities to explore opportunities for collaboration and cross-pollination between these fields. Panelists discuss the talent bottleneck in longevity research, challenges in translating new discoveries into therapies, the need for improved communication and education, and a shared vision for transforming heal...
Nurturing the Next Generation of Leaders in Aging Biology (Dr. Courtney Hudson-Paz, Time Initiative)
May 17, 2023 07:30 - 22 minutes - 15.7 MBIn this episode of Translating Aging, host Chris Patil is joined by Dr. Courtney Hudson-Paz, the Founder and Program Director of the Time Initiative, an organization whose mission is to build a network of undergraduate leaders in aging biology. Courtney takes us on a journey into the world of aging biology and the mission of the Time Initiative, highlighting how this groundbreaking organization is cultivating the next generation of leaders. She shares her insights into the importance of ear...
Epigenetic Reprogramming Therapies to Extend Healthspan (Dr. Jacob Kimmel, Head of Research, NewLimit)
May 03, 2023 07:30 - 40 minutes - 27.7 MBJacob Kimball is the Head of Research and co-founder of NewLimit, a company aiming to develop epigenetic reprogramming therapies to treat age-related diseases and extend human healthspan. In this episode, Chris and Jacob have an in-depth discussion about NewLimit’s mission and approach. They explore how NewLimit is leveraging epigenetics and machine learning to search for new ways to reverse cell aging without changing cell identity. NewLimit is systematically testing combinations of biolog...
A New Approach for Cardiovascular Disease (Dr. Matthew O’Connor, Cyclarity Therapeutics)
March 15, 2023 07:30 - 37 minutes - 26 MBIn today’s episode, Chris is joined by Dr. Matthew "Oki" O'Connor, CEO for Scientific Affairs at Cyclarity Therapeutics, a company focused on eliminating arterial plaque, a prevalent issue in old age. Dr. O'Connor shares his insights on the causes and effects of atherosclerosis, the leading cause of death worldwide, and how aging contributes to plaque build-up. The podcast emphasizes the need for a paradigm shift in addressing cardiovascular disease and highlights the importance of new appro...
Targeting Pathologic Cells to Preserve Biological Youth (Dr. Marco Quarta, Rubedo Life Sciences)
February 22, 2023 07:30 - 40 minutes - 28.1 MBDr. Marco Quarta, CEO and Co-founder of Rubedo Life Sciences, joins Chris on today’s episode to discuss his company’s strategy of targeting pathologic cells to develop therapeutics for chronic degenerative conditions. The conversation covers the evolving definition of senescence and the challenges of identifying and classifying pathologic cells, which vary across different tissues and indications. Marco also announces the upcoming Senotherapeutic Summit in November, which will bring together...
Bone Marrow Banking for Cell Therapy Material at Scale (Kevin Caldwell, Ossium Health)
January 25, 2023 07:30 - 41 minutes - 28.3 MBIn today’s episode, Chris sits down with Kevin Caldwell, CEO, Co-Founder, and President of Ossium Health, a company that aims to improve human health and longevity through bioengineering - specifically using stem cell science to create materials for cell therapies. Together, they discuss Ossium’s approach: processing and banking of bone marrow from organ donors, which can then be cryopreserved and used for various clinical applications such as bone marrow transplants for blood cancer patient...
Hacking the Complex System of Aging (Peter Fedichev, GERO)
December 14, 2022 07:30 - 41 minutes - 28.4 MBThis week, we welcomes Peter Fedichev, an entrepreneur and scientist with over 20 years of experience in academic research and biotech business who has co-founded three biotech companies. He’s currently the co-founder & CEO of GERO, a longevity startup on a mission to hack aging. In this episode, Chris and Peter discuss GERO’s goal to accelerate our understanding of aging and create a therapy that will significantly extend a healthy human lifespan. First, they talk about the relationship b...
Understanding Aging to Develop Interventions (Morten Scheibye-Knudsen, University of Copenhagen)
November 16, 2022 07:30 - 32 minutes - 22.6 MBThis week, Chris welcomes Morten Scheibye-Knudsen, Associate Professor at the University of Copenhagen, who’s on a mission to understand, modulate and treat aging and age-related diseases. His research group, The Scheibye-Knudsen Lab, is trying to understand the cellular and organismal consequences of DNA damage & repair with the aim of developing interventions for aging. Morten is also one of the chairs and chief organizers of the highly successful aging research and Drug Discovery conferen...
Optimizing Healthspan through Longevity Medicine (Dr. Andrea Maier – The Center for Healthy Longevity)
October 12, 2022 07:30 - 37 minutes - 25.5 MBOptimizing Healthspan through Longevity Medicine (Dr. Andrea Maier – The Center for Healthy Longevity) Dr. Andrea Maier is an internal medicine specialist, geriatrician, and researcher whose work focuses on age-related disease, cellular senescence, and the translation of longevity science into clinical practice. Among her academic appointments are professorships at the Free University, Amsterdam and the Netherlands, the University of Melbourne in Australia, and the National University of Si...
Investing in Longbio True Believers (Sebastian Brunemeier, Healthspan Capital & ImmuneAge Pharma)
September 28, 2022 07:30 - 44 minutes - 30.2 MBIn today’s episode, Chris welcomes Sebastian Brunemeier, a biotech VC and company builder focused on longevity and regenerative medicine. Sebastien is the Co-Founder and General Partner of Healthspan Capital, a longevity VC firm that invests in biotechnology startups developing therapies to slow or reverse aging, and the CEO and Co-Founder of ImmuneAGE Pharma, a new company based on a drug discovery platform for immune rejuvenation. At Healthspan Capital, Sebastian is looking to invest in f...
Investing in Longevity (Nils Regge, Apollo Health Ventures)
September 14, 2022 07:30 - 27 minutes - 18.6 MBJoining Chris on the podcast today is Nils Regge, Co-founder and Managing Director of Apollo Health Ventures. As a social entrepreneur, company creator, and biotech expert, Nils built Apollo Health Ventures in 2016 to help health tech companies develop methods to prevent and reverse the aging process and extend the healthy human life span. At Apollo, Nils makes use of his dealmaking skills, business knowledge, and prior experience growing startups to help boost the success of biotech and...
Safe & Synergistic Combination Drugs to Promote Healthy Aging (Ann Beliën, Rejuvenate BioMed)
August 24, 2022 07:30 - 36 minutes - 33.3 MBIn this episode of the BioAge podcast, Ann Beliën joins Chris Patil today to share the story behind Rejuvenate Biomed, and her journey into the longevity sector. She started her career at Johnson & Johnson after receiving her postdoctoral degree, and during her tenure, she worked in scientific, operational, and strategic roles. Twenty years later, she became the founder and CEO of Rejuvenate Biomed, a Belgian company evaluating combinations of safe and synergistic drugs that target physica...
Building Longevity Companies in Europe (Marc Bernegger)
August 10, 2022 07:30 - 22 minutes - 20.3 MBToday’s guest on the podcast is Marc Bernegger, a serial tech entrepreneur who has been following developments in the field of longevity since 2009. Recently he became a founding partner of the Swiss company, Maximon, whose core missions is building companies and providing support to longevity entrepreneurs. Marc has worked for over a decade between two continents at this point, and his interest in longevity has never been more intense. From aging skin to gut microbiomes, there’s a lot of wo...
Building Longevity Companies in Europe (Marc P. Bernegger)
August 10, 2022 07:30 - 22 minutes - 20.3 MBToday’s guest on the podcast is Marc Bernegger, a serial tech entrepreneur who has been following developments in the field of longevity since 2009. Recently he became a founding partner of the Swiss company, Maximon, whose core missions is building companies and providing support to longevity entrepreneurs. Marc has worked for over a decade between two continents at this point, and his interest in longevity has never been more intense. From aging skin to gut microbiomes, there’s a lot of ...
Defining and Measuring the Aging Process (Dr. Vadim Gladyshev)
July 27, 2022 07:30 - 31 minutes - 29.2 MBJoining Chris today is Dr. Vadim Gladyshev, Professor of Medicine at Harvard Medical School, Director of Redox Medicine at Brigham and Women's Hospital, and a member of the National Academy of Sciences. The Gladyshev lab studies redox biology and trace elements as they relate to cancer, reproduction, and aging. Today, Dr. Gladyshev shares with us how his research group investigates the aging process and how aging is quantified in academic research. Dr. Gladyshev begins by discussing how he ...
AI and Robotics in Longevity Biotech (Alex Zhavoronkov)
July 06, 2022 07:30 - 24 minutes - 22.7 MBJoining Chris today is Alex Zhavoronkov, CEO and Co-founder of Insilico Medicine, an artificial intelligence–driven pharma-technology company with a mission to accelerate drug discovery and development. Alex is a lifelong advocate for longevity biotech and the author of The Ageless Generation: How Advances in Biomedicine Will Transform the Global Economy. Today, Alex shares the accomplishments that Insilico Medicine has achieved in drug discovery and how AI and robotics come into play. The ...
The Impact of Muscle Aging on Longevity (Dr. Bill Evans)
June 22, 2022 07:30 - 43 minutes - 39.5 MBBack in the host's chair this week, Bob Hughes welcomes Dr. Bill Evans, one of the world's foremost experts on muscle aging, to the podcast. Bill is adjunct professor of Human Nutrition at University of California Berkeley and an adjunct professor of medicine in the Geriatrics Program at Duke. Previously, he was vice president and head of Muscle Metabolism Discovery Performance Unit at GlaxoSmithKline and he was also president of the Muscle and Health Division at KineMed. He was also preside...
Eliminating Senescent Cells by Activating the Immune System (Robin Mansukhani, Deciduous Therapeutics)
June 08, 2022 07:30 - 43 minutes - 39.9 MBThis week’s episode of Translating Aging features Robin Mansukhani, CEO and Co-founder of Deciduous Therapeutics, a company that aims to positively impact human healthspan by developing medicines which activate the endogenous immune mechanism responsible for the elimination of senescent cells. Today, Robin shares his insights on how senescent cells develop and how Deciduous Therapeutics eliminates them. Robin begins by explaining what causes the growth of senescent cells. He explains that n...
Bringing Talent into the Longevity Industry’s Workforce (Mark Hamalainen)
May 18, 2022 07:30 - 34 minutes - 31.2 MBIn today’s episode of Translating Aging, Chris welcomes Mark Hamalainen, the founder and director of LessDeath, to discuss how to encourage the influx of talents into the longevity field. LessDeath is an organization on a mission to support the growth and effectiveness of the longevity industry’s workforce. Today, Mark shares with us his experience in the longevity space, why he founded LessDeath, and what to expect at the upcoming LessDeath Longevity Summer Camp. Noting that his experience...
VitaDAO - Democratizing Longevity Research through the Blockchain (Tyler Golato and Laurence Ion)
May 04, 2022 07:30 - 49 minutes - 34.3 MBOn today’s episode of Translating Aging, Chris welcomes Tyler Golato and Laurence Ion to talk about VitaDAO, a collective accelerating research in human longevity and decentralized drug development. The pair start the conversation off by discussing their company’s roots - a previous business venture that sought to change the incentive structures around drug development. VitaDAO was created as a means to support biological longevity research through decentralized means. They go on to di...
Building Community in the Longevity Biotech Space (Nathan Cheng)
April 06, 2022 07:30 - 34 minutes - 31.7 MBOn today’s episode of Translating Aging, Chris welcomes Nathan Cheng, the program director at On Deck Longevity Biotech (ODLB), to discuss how ODLB is cultivating new founders and connecting people in the longevity biotech space. Nathan writes about the longevity biotech industry in his Longevity Marketcap Newsletter, is the founder of Longevity List which aims to connect job seekers, companies and investors in the longevity industry, and is on a self-professed mission to end biological agin...
Aging Goes to Washington! — The Alliance for Longevity Initiatives (Sonia Arrison and Dylan Livingston)
March 23, 2022 07:30 - 37 minutes - 34.1 MBIn today's episode, Chris is joined by two leaders of the Alliance for Longevity Initiatives, A4LI, the first and only 501(c)(4) nonprofit organization founded with the goal of creating social and political action around the issues of combating age-related chronic conditions and increasing our number of healthy, disease-free years. Sonia Arrison is a best-selling author, analyst, entrepreneur, and investor who is founder of 100 Plus Capital, Chair of the Alliance for Longevity Initiatives, ...
Measuring Biological Age (Dr. Morgan Levine)
March 09, 2022 07:30 - 46 minutes - 42.7 MBToday’s guest is Dr. Morgan Levine, an assistant professor of Pathology and Epidemiology at Yale School of Medicine. She is also a Founding Principal Investigator at Altos, a new biotechnology company focused on cellular rejuvenation programming to restore cell health and resilience. Dr. Levine shares her expertise on biological aging, aging clocks, cellular reprogramming, and a peek into the research she’s currently undertaking at Altos here today. She starts the conversation by explaining...
Stem Cell Biology and Longevity Research with Dr. Thomas Rando
February 23, 2022 07:30 - 47 minutes - 32.7 MBToday’s guest is Dr. Thomas Rando, Professor, Neurology; Molecular, Cell and Developmental Biology, and a pioneer in stem cell biology and the biology of aging. Dr. Rando is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles, and the co-founder and Chair of the Board of Directors at Fountain Therapeutics. In today’s episode, he shares information surrounding cell cycle, parabiosis, and replacement thera...
Cellular senescence in aging and disease (Dr. Marco Demaria)
February 09, 2022 07:30 - 35 minutes - 24.4 MBDr. Marco Demaria is an Associate Professor in Cellular Ageing at the Medical Faculty of the University of Groningen. In 2018, he co-founded a start-up company, Cleara Biotech, devoted to developing anti-senescence drugs. Today, Dr. Demaria shares his insights and research on how senescence promotes aging and factors that promote the creation of senescent cells. In this episode, Dr. Demaria explains what cellular senescence means and discusses the good and bad that comes with having senesce...
The TAME trial and beyond (Dr. Nir Barzilai — AECOM)
January 26, 2022 07:30 - 48 minutes - 33.4 MBThe TAME trial and beyond (Dr. Nir Barzilai) Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging, and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University. He is also the author of the book Age Later. Today, Dr. Nir brings his expertise to the podcast for a discussion regarding longevity and aging. Nir starts the conversatio...
Natural history & the evolution of aging (Professor Steven Austad — University of Alabama)
January 12, 2022 07:30 - 36 minutes - 33.1 MBProfessor Steven Austad is a distinguished researcher in geroscience and the Protective Life Endowed Chair in Healthy Aging at the University of Alabama at Birmingham. He's also the Director of the Nathan Shock Center at UAB and the Senior Scientific Director of the American Federation for Aging Research. Today, Professor Austad joins Bob Hughes to discuss the biology of aging. He begins by narrating the discovery that sparked his interest in aging and his transition from animal behavior to...
Personalized cell therapies at scale (Dr. Nabiha Saklayen — Cellino)
December 15, 2021 07:30 - 36 minutes - 25.2 MBDr. Nabiha Saklayen is CEO & co-founder of Cellino, a personalized regenerative medicine company developing an AI-guided laser editing platform for autologous cell-based therapies. Cellino’s proprietary technology aims to make personalized stem cell-derived therapies scalable for the first time. Dr. Saklayen received her Ph.D. in Physics from Harvard University as a Howard Hughes Medical Institute (HHMI) International Fellow. In this episode, she joins Chris Patil to discuss autologous c...
DISCO: A New Model for Entrepreneurship in Longevity Biotech (Dr. James Peyer — Cambrian Biopharma)
December 01, 2021 07:30 - 45 minutes - 41.3 MBDr. James Peyer, PhD, is the Founder and CEO of Cambrian Biopharma, a Distributed xDevelopment Company developing therapeutics targeting the biological drivers of aging. Cambrian Biopharma brings together experts, scientists, and experienced company builders in a new model of entrepreneurship related to health span and aging. Dr. Peyer was previously the founder of Apollo Ventures, a successful venture capital firm focused on the longevity biotech space. He has spoken on the topic of longev...
Big Data and Human Health & Longevity (Prof. Michael Snyder — Stanford Medicine)
November 10, 2021 07:30 - 40 minutes - 27.6 MBProfessor Michael Snyder is the Chair of Genetics at Stanford School of Medicine, where his research group develops and uses technologies to study biological regulatory networks and applies these approaches to understand human variation and health. He's founded multiple biotech startups and has authored a book titled Genomics and Personalized Medicine: What Everyone Needs to Know. Today, Professor Snyder joins host Bob Hughes to discuss the impact of big data on human health. He reviews ...
Accelerating drug discovery for aging and its diseases (Ben Kamens - Spring Discovery)
October 27, 2021 07:30 - 42 minutes - 29 MBBen Kamens is the founder and CEO of Spring Discovery, a company devoted to accelerating therapies for aging and its diseases. Prior to that, Ben was the first engineer for Khan Academy, which provides free online education to millions of users around the world. Today Ben joins host Chris Patil to discuss Spring Discovery’s mission to increase healthy lifespan and dramatically reduce disease, his experience with Khan Academy and how it connected to his work in biotechnology, and overcoming c...
The naked mole rat: A model of successful aging (Dr. Rochelle Buffenstein — Calico Life Sciences)
October 13, 2021 07:30 - 45 minutes - 30.9 MBRochelle Buffenstein is one of the world’s leading authorities on the naked mole rat, a fascinating animal that has emerged as an important model for research in longevity science. Dr. Buffenstein is currently a senior principal investigator at Calico Life Sciences, a subsidiary of Alphabet, that is seeking to better understand the biology that controls aging and lifespan. Today Dr. Buffenstein joins host Bob Hughes to explain why the naked mole rat is such a powerful model of successful a...
Building networks and community around aging research (Leanne Jones and Saul Villeda of the Bakar Aging Research Institute)
September 29, 2021 07:30 - 36 minutes - 25 MBEarlier this year, the University of California San Francisco launched the Bakar Aging Research Institute (BARI), a scientific community that aims to translate breakthroughs in aging research across many disciplines into new approaches and treatments that help people remain healthy and vibrant in later life. Here to tell us about the Institute are Professor Leanne Jones, who moved from UCLA to UCSF to serve as Director of BARI, and Associate Professor and Associate Director of BARI, Saul Vil...
Gene therapy screening to discover aging targets (Martin Borch Jensen - Gordian Biotechnology)
September 15, 2021 07:30 - 55 minutes - 38.2 MBGene therapy screening to discover aging targets (Martin Borch Jensen - Gordian Biotechnology) Gordian Biotechnology is a San Francisco Bay Area biotech company that has created the first in vivo therapeutic screening platform aimed at drug development for complex diseases of aging. Co-founder and Chief Science Officer, Dr. Martin Borch Jensen joins the show today to discuss Gordian’s unique in vivo pooled screening in animals, as well as which indications they are targeting, their strateg...
Changing the Narrative on Women’s Reproductive Longevity (Dr. Jennifer Garrison, Buck Institute & GCRLE)
September 01, 2021 07:30 - 49 minutes - 33.9 MBOn today’s episode is Dr. Jennifer Garrison, Professor at the Buck Institute for Research on Aging, and the Faculty Director of the Global Consortium for Reproductive Longevity and Equality (GCRLE), which is devoted to supporting breakthrough research on reproductive aging and women in science through funding, training, infrastructure, and collaborative intellectual networks. Dr. Garrison explains that while there are plenty of scientists working on aging and plenty who are working on repr...
The Cures Within Us (Hanadie Yousef — Juvena Therapeutics)
August 18, 2021 07:30 - 39 minutes - 26.8 MBDr. Hanadie Yousef is a scientist, aging biology expert and the co-founder and CEO of Juvena Therapeutics, a Palo Alto-based biopharma startup developing protein-based therapeutics to promote tissue regeneration and increase healthspan to prevent, reverse, and cure degenerative diseases. Dr. Yousef joins host Dr. Chris Patil to discuss Juvena’s premise, their use of a machine learning platform to identify proteins that have therapeutic potential, and what most excites her about turning sig...
The Dog Aging Project: Understanding longevity in our canine companions
August 04, 2021 07:30 - 1 hour - 41.2 MBThe Dog Aging Project is an innovative initiative that brings together a community of dogs, owners, veterinarians, researchers, and volunteers to carry out the most ambitious canine health study in the world. The goal of the Dog Aging Project is to understand how genes, lifestyle, and environment influence aging, and to use that information to help pets and people increase their healthspan, the period of life spent free from disease. Co-directors Dr. Daniel Promislow and Dr. Matt Kaeberlei...
Giving our best friends more time: Healthy aging for dogs (Celine Halioua, CEO of Loyal)
July 21, 2021 07:30 - 40 minutes - 28.1 MBLoyal is a San Francisco-based startup that is seeking to treat the underlying causes of aging in dogs. Loyal has raised $11 million in seed funding so far, and is planning to start clinical trials of medications in 2022 and 2023. In this episode, BioAge VP-Media Chris Patil talks with Celine Halioua, CEO and founder of Loyal. Celine beginswith by describing the striking difference in lifespan among the dog species, with smaller breeds like the Chihuahua living twice as long as larger breed...
Unlocking animal biology to fight disease in humans (Dr. Ashley Zehnder — CEO, Fauna Bio)
July 07, 2021 07:30 - 38 minutes - 26.4 MBDr. Ashley Zehnder is the co-founder and CEO of Fauna Bio, a San Francisco, Bay Area-based company founded in 2018. Fauna Bio has adopted a fascinating strategy for drug development, studying animal genomics to cure human diseases. They use unique and varied proprietary data sources to identify novel drug targets across a range of clinical applications, beginning with cardiovascular protection. Dr. Zehnder is a veterinarian-scientist at the intersection of animal biology and human health. To...