Oscar Julian Booker, MD and Efstathia Andrikopoulou MD discuss how using third-party vendor, Mpirik Cardiac Intelligence, helped to develop a software algorithm that provides clinical decision support to help identify patients at risk for heart valve disease who otherwise might be overlooked. They share what factors are behind the most significant disparities, as they connect the potential of machine learning and artificial intelligence with the need for clinicians to expand their toolkit. They offer their top recommendations for physicians to consider when they are treating underserved and minority patients.