STI infection rates are generally increasing in the U.S., and this is especially concerning for pregnant women; for instance, in just the last five years, congenital syphilis cases have jumped 200%. Jodie Dionne-Odom, MD, MSPH, FIDSA, defines the categories of STIs and explains possible reasons behind the increase. She emphasizes the need for early testing and treatment of pregnant women and discusses some of the advances in testing that may lead to convenient, at-home sample collection options. Learn about the clinical trials in progress at UAB exploring vaccines and antibiotics for common STIs.