Exercise can improve lung function and have a range of other benefits for cystic fibrosis (CF) patients, but each patient has a unique tolerance for exercise depending on age, condition, and lifestyle. Stefanie Krick, MD, discusses how the complications specific to CF require popular exercises to be modified. She also emphasizes that patients must be monitored closely for changing abilities in each phase of their lives. Multidisciplinary teams that include physical therapists are best suited to help patients with special challenges due to CF make exercise part of their lives safely.