Pulmonologists have noted an exciting “baby boom” among women with Cystic Fibrosis (CF) in the last several years. As Gretchen Winter, MD, explains, CFTR modulators have led to increased fertility and the prospect of family planning for those with CF. She discusses the unique concerns those with CF may have when making reproductive decisions, such as effective contraception; safety of CFTR modulator use during both pregnancy and breastfeeding; and the risk of passing on the genetic disease. She also presents the different pathways to parenthood available for women and men with CF.