Hematologic cancer patients have the benefit of many new oral medications to manage their conditions; however, those medications may create or worsen cardiovascular comorbidities. Nurse Practitioners Courtney Estes (Cardio-Oncology Program) and Ellen Lazarre (Hematology Oncology Division) discuss the balancing act of managing risks while attacking cancer, which is only possible with an interdisciplinary team. They discuss the most common cardiovascular comorbidities (e.g., AFib, hypertension) and alternative treatments that may address them without interfering with effective cancer treatments.